{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:50:35Z","timestamp":1787021435822,"version":"build-2736575974"},"update-to":[{"DOI":"10.12688\/f1000research.26879.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:00:00Z","timestamp":1614643200000}}],"reference-count":63,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T00:00:00Z","timestamp":1614643200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    <ns3:bold>Background:<\/ns3:bold>\n                    Neovascular glaucoma (NVG) is a severe, potentially blinding disease and a therapeutic challenge. The purpose of this study was to evaluate the safety and efficacy of an integrative surgical approach to neovascular glaucoma.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Methods:<\/ns3:bold>\n                    Retrospective analysis of a one-year follow-up of a consecutive interventional case series of NVG. Eyes underwent transscleral cyclophotocoagulation, pars plana vitrectomy, near-confluent panretinal photocoagulation, and intravitreal bevacizumab. Phakic eyes underwent concomitant cataract surgery. Best-corrected visual acuity (BCVA, logMAR), intraocular pressure (IOP, mmHg), number of glaucoma medication, visual analog pain scale (VAPS, 0-10) were recorded at baseline, and 1, 3, 6, and 12 months. Blind eyes were excluded.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Results:<\/ns3:bold>\n                    Seventy-seven eyes of 77 patients (45 male, 32 female, mean age 73.6\u00b112.2 years) were included. NVG underlying conditions included retinal vein occlusion (41.6%), proliferative diabetic retinopathy (35.1%), central retinal artery occlusion (19.5%), and ocular ischemic syndrome (3.9%). Mean IOP decreased postoperatively from 46.3\u00b110.1 mmHg to 14.5\u00b17.9 mmHg (p&lt;0.001), glaucoma medication from 4.7\u00b11.3 to 1.8\u00b11.8 (p&lt;0.001), and VAPS from 6.0\u00b11.8 to 0. BCVA remained unchanged. Postoperative intraocular inflammation had resolved in all eyes at the one-month follow-up. 71.4% (55\/77) eyes did not require additional major interventions during follow-up.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Conclusions:<\/ns3:bold>\n                    A single, comprehensive surgery session lowered IOP significantly, reduced GMS, and controlled pain.\n                  <\/ns3:p>","DOI":"10.12688\/f1000research.26879.2","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T08:45:39Z","timestamp":1614674739000},"page":"1236","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Combined vitrectomy, near-confluent panretinal endolaser, bevacizumab and cyclophotocoagulation for neovascular glaucoma \u2014 a retrospective interventional case series"],"prefix":"10.12688","volume":"9","author":[{"given":"Piotr","family":"Strzalkowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicja","family":"Strzalkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winfried","family":"G\u00f6bel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7167-1213","authenticated-orcid":false,"given":"Nils A.","family":"Loewen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jost","family":"Hillenkamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2021,3,2]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"dev151019","DOI":"10.1242\/dev.151019","article-title":"Vascular endothelial growth factor signaling in development and disease.","volume":"145","author":"S Karaman","year":"2018","journal-title":"Development."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s12886-016-0190-8","article-title":"Neovascular glaucoma: a retrospective review from a tertiary center in China.","volume":"16","author":"N Liao","year":"2016","journal-title":"BMC Ophthalmol."},{"key":"ref-3","doi-asserted-by":"crossref","first-page":"138-40","DOI":"10.1055\/s-2008-1055033","article-title":"Das h\u00e4morrhagische Sekund\u00e4rglaukom.","volume":"180","author":"P Drobec","year":"1982","journal-title":"Klinische Monatsbl\u00e4tter f\u00fcr Augenheilkunde."},{"key":"ref-4","first-page":"58-65","article-title":"[Neovascular glaucoma--retrospective study].","volume":"49","author":"C Mocanu","year":"2005","journal-title":"Oftalmologia."},{"key":"ref-5","article-title":"Diagnosedaten der Krankenh\u00e4user ab 2000 (Eckdaten der vollstation\u00e4ren Patienten und Patientinnen)"},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"486-91","DOI":"10.1001\/archopht.1997.01100150488006","article-title":"Natural History and Clinical Management of Central Retinal Vein Occlusion.The Central Vein Occlusion Study Group.","volume":"115","year":"1997","journal-title":"Arch Ophthalmol."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"662-72","DOI":"10.1111\/j.1755-3768.1983.tb04357.x","article-title":"The prevalence of glaucoma and ocular hypertension in type 1 and 2 diabetes mellitus.","volume":"61","author":"N Nielsen","year":"1983","journal-title":"Acta Ophthalmol (Copenh)."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"1042-6","DOI":"10.1177\/112067211002000603","article-title":"Ocular neovascularization following central retinal artery occlusion: prevalence and timing of onset.","volume":"20","author":"A Rudkin","year":"2010","journal-title":"Eur J Ophthalmol."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"315-20","DOI":"10.1016\/s0161-6420(84)34293-2","article-title":"Neovascular glaucoma. 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