{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:32:48Z","timestamp":1792801968565,"version":"4.5.0"},"update-to":[{"DOI":"10.12688\/f1000research.27495.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T00:00:00Z","timestamp":1621900800000}}],"reference-count":45,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T00:00:00Z","timestamp":1621900800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Consejer\u00eda de Educaci\u00f3n, Cultura y Deportes, JCCM","award":["CCM17-PIC-036 (SBPLY\/17\/180501\/000185)"],"award-info":[{"award-number":["CCM17-PIC-036 (SBPLY\/17\/180501\/000185)"]}],"id":[{"id":"https:\/\/ror.org\/00t864161","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Humans evolved by losing the capacity to synthesize the glycan Gal\u03b11-3Gal\u03b21-(3)4GlcNAc-R (\u03b1-Gal), which resulted in the development of a\u00a0protective response mediated by anti-\u03b1-Gal IgM\/IgG\/IgA antibodies against pathogens containing this modification on membrane proteins. As an evolutionary trade-off, humans can develop the\u00a0alpha-Gal syndrome (AGS),\u00a0a recently diagnosed disease mediated by\u00a0anti-\u03b1-Gal IgE antibodies and associated with allergic reactions to mammalian meat consumption and tick bites. However, the\u00a0anti-\u03b1-Gal antibody response may be associated with other immune-mediated disorders such as those occurring in patients with COVID-19 and\u00a0Guillain-Barr\u00e9\u00a0syndrome (GBS). Here, we provide a dataset (209 entries) on the IgE\/IgM\/IgG\/IgA\u00a0anti-\u03b1-Gal antibody response in healthy individuals and patients diagnosed with AGS, tick-borne allergies, GBS and COVID-19. The data allows correlative analyses of the\u00a0anti-\u03b1-Gal antibody response with factors such as patient and clinical characteristics, record of tick bites, blood group, age and sex. These analyses could provide insights into the role of\u00a0anti-\u03b1-Gal antibody response in disease symptomatology and possible protective mechanisms.<\/ns3:p>","DOI":"10.12688\/f1000research.27495.2","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T11:37:03Z","timestamp":1621942623000},"page":"1366","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["A dataset for the analysis of antibody response to glycan alpha-Gal in individuals with immune-mediated disorders"],"prefix":"10.12688","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7383-9649","authenticated-orcid":false,"given":"Jos\u00e9","family":"de la Fuente","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 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Mera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Villar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen M.","family":"Cabrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar","family":"G\u00f3mez Hernando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Vargas Baquero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Blanco Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Rodr\u00edguez G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Velayos Gal\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Feo Brito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"G\u00f3mez Torrijos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Cabezas-Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Gort\u00e1zar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2021,5,25]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"213-220","DOI":"10.1016\/j.ijpara.2015.12.005","article-title":"Amblyomma sculptum tick saliva: \u03b1-Gal identification, antibody response and possible association with red meat allergy in 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Yilmaz","year":"2014","journal-title":"Cell."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/9-1366\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/9-1366\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/9-1366\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T09:10:39Z","timestamp":1628759439000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/9-1366\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,25]]},"references-count":45,"URL":"https:\/\/doi.org\/10.12688\/f1000research.27495.2","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.57019.r86098","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.57019.r86099","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.57019.r91810","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.57019.r86098","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.57019.r91810","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.57019.r86099","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,25]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/9-1366\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.57019.r86099, Jacques Le Pendu, CRCINA, Universit\u00e9 de Nantes, Inserm, Nantes, France, 26 May 2021, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/9-1366\/v2#referee-response-86099","order":0,"name":"referee-response-86099","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.57019.r86098, Tilo Biedermann, Department of Dermatology and Allergology, Technical University of Munich, Munich, Germany, 20 Jul 2021, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/9-1366\/v2#referee-response-86098","order":1,"name":"referee-response-86098","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Jose de la Fuente<\/b>; \n<i>Posted: 21 Jul 2021<\/i>; We appreciate reviewer comments, but consider that the information addressing these comments was provided in the previous response and revised manuscript. Exposure to ticks is always a variable that is difficult to fully address although this question was included in data collection as reflected in the database associated to the paper. Therefore, we have no further revisions in response to these comments.","URL":"https:\/\/f1000research.com\/articles\/9-1366\/v2#referee-comment-6941","order":2,"name":"referee-comment-6941","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.57019.r91810, Mona Mahmoud, Parasitology and Animal Diseases Department, National Research Center, Giza, Egypt, 12 Aug 2021, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/9-1366\/v2#referee-response-91810","order":3,"name":"referee-response-91810","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This work was partially supported by the Consejer\u00eda de Educaci\u00f3n, Cultura y Deportes, JCCM, Spain, project CCM17-PIC-036 (SBPLY\/17\/180501\/000185). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}