{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T22:47:50Z","timestamp":1783723670694,"version":"3.55.0"},"update-to":[{"DOI":"10.12688\/f1000research.28005.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000}}],"reference-count":22,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    <ns3:bold>Background:<\/ns3:bold>\n                    Bleeding from esophageal varices is a life-threatening complication in cirrhosis. Screening endoscopy is recommended in cirrhotic patients to identify patients at risk of variceal hemorrhage, but this is an invasive procedure and has limitations. Therefore, thrombocytopenia has been proposed to predict the existence and grade of esophageal varices. The aim of the current study was to determine a correlation between platelet count and grades of esophageal varices in patients with liver cirrhosis.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Methods:<\/ns3:bold>\n                    This cross-sectional study was conducted at the POF Hospital, Wah Cantt from 1\n                    <ns3:sup>st<\/ns3:sup>\n                    October, 2017 to 30\n                    <ns3:sup>th<\/ns3:sup>\n                    May, 2018. Newly diagnosed cases of cirrhosis having varices of any grade on endoscopy were included. Endoscopic findings of patients were standardized using Paquet grading system. On the basis of platelet count, patients were divided into four subgroups. Platelet count groups were correlated with grading of esophageal varices using Spearman rank correlations. Chi Square test was used to see association between the platelet count and grade of esophageal varices.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Results:<\/ns3:bold>\n                    110 patients were included in the study, 55.5% (n=61) were male. Mean age of the patients was 59.89\u00b19.01 years. Platelet count was &lt;50,000\/uL in 35.5% patients, 50,000-99,000\/uL in 26.4%, 100,000-150000 in 12.7%, and &gt;150,000\/uL in 25.5% patients. Grade I esophageal varices were found in 23.6% of patients, whereas grade II, III and IV were found in 24.5%, 33.6% and 18.2% of patients, respectively. Mean platelet count was 213884.62\/mm\n                    <ns3:sup>3<\/ns3:sup>\n                    in patients with grade I varices, whereas it was 119518.52\/mm\n                    <ns3:sup>3<\/ns3:sup>\n                    , 58386.49\/mm\n                    <ns3:sup>3<\/ns3:sup>\n                    and 21600.00\/mm\n                    <ns3:sup>3<\/ns3:sup>\n                    in patients with grade II, III and IV varices, respectively (p=&lt;0.0001). A significant negative correlation between platelet count and grades of esophageal varices was found (p&lt;0.001).\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Conclusion:<\/ns3:bold>\n                    Platelet count can predict the grade of esophageal varices in cirrhotic patients. There is significant negative correlation between platelet count and grades of esophageal varices.\n                  <\/ns3:p>","DOI":"10.12688\/f1000research.28005.2","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T11:50:06Z","timestamp":1637754606000},"page":"101","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Platelet count can predict the grade of esophageal varices in cirrhotic patients: a cross-sectional study"],"prefix":"10.12688","volume":"10","author":[{"given":"Anum","family":"Afsar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6262-7365","authenticated-orcid":false,"given":"Muhammad","family":"Nadeem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5722-3879","authenticated-orcid":false,"given":"Syed Asim 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Afsar","year":"2020","journal-title":"figshare."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/10-101\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/10-101\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/10-101\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T03:55:17Z","timestamp":1641268517000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/10-101\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,24]]},"references-count":22,"URL":"https:\/\/doi.org\/10.12688\/f1000research.28005.2","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.79401.r101100","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.79401.r101100","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.79401.r101099","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,24]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/10-101\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.30974.r87611, Muhammad Asim Anwar, Pakistan Atomic Energy Commission, Islamabad, Pakistan, 30 Jun 2021, version 1, 1 approved, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/10-101\/v1#referee-response-87611","order":0,"name":"referee-response-87611","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Muhammad Nadeem<\/b>; \n<i>Posted: 11 Nov 2021<\/i>; We would like to thank the reviewer for his valuable time and comments on our article; this will be very helpful for us in future research.  We added the some details of other non invasive methods in discussion as advised by&nbsp;reviewer","URL":"https:\/\/f1000research.com\/articles\/10-101\/v2#referee-comment-7422","order":1,"name":"referee-comment-7422","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.79401.r101100, Alexandru Constantin Moldoveanu, Gastroenterology and Internal Medicine II Clinic - University Emergency Hospital Bucharest, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, 04 Jan 2022, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/10-101\/v2#referee-response-101100","order":2,"name":"referee-response-101100","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}