{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T06:00:58Z","timestamp":1782453658721,"version":"3.54.5"},"update-to":[{"DOI":"10.12688\/f1000research.28454.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000}}],"reference-count":27,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background:<\/ns4:bold>\n                    Rabies is a neglected zoonotic disease. It is transmitted through the bite of a rabid animal and dog bites are responsible for around 95% of human cases. The disease is almost always fatal after the onset of symptoms. It is an endemic and major public health problem in India with one-third of the global deaths reported from this country.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Protocol:<\/ns4:bold>\n                    This systematic review aims to estimate the epidemiological, humanistic and economic burden of dog-mediated rabies in India. Initially the existence of controlled descriptors in MeSH terms (such as 'Epidemiology', 'Rabies', 'Cost', 'Dog bite', 'Quality of Life', 'India' etc), and their synonyms (key words) was identified in MEDLINE, and were later combined with Boolean operators 'AND' and 'OR' to develop a detailed search strategy. Two independent reviewers will screen the titles and abstracts and select the studies as per the inclusion criteria. The selected studies will be assessed for their quality and risk of bias. Data will be extracted using standardized data extraction tools and will be synthesized for analysis. Disagreements that arise between the reviewers will be resolved through discussion, or with a third reviewer.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Discussion:<\/ns4:bold>\n                    This systematic review will be performed to critically examine relevant literature and report the epidemiological, humanistic and economic burden of dog-mediated rabies in Indian context. The findings will help in estimation of burden of the disease in India and expected to contribute in policy making and planning of the program and interventions in the country.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Protocol registration:<\/ns4:bold>\n                    PROSPERO ID:\n                    <ns4:ext-link xmlns:ns5=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" ns5:href=\"https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?RecordID=213261\">CRD4202021326<\/ns4:ext-link>\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.28454.2","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T08:55:08Z","timestamp":1620809708000},"page":"32","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Epidemiological, humanistic and economic burden of dog-mediated rabies in India: a systematic review protocol"],"prefix":"10.12688","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4486-632X","authenticated-orcid":false,"given":"Denny","family":"John","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2264-8647","authenticated-orcid":false,"given":"Abhishek","family":"Royal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omesh","family":"Bharti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2021,5,12]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"e0003709","DOI":"10.1371\/journal.pntd.0003709","article-title":"Estimating the global burden of endemic canine rabies.","volume":"9","author":"K Hampson","year":"2015 cited 2020 Jul 8","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-2","first-page":"139","article-title":"WHO Expert Consultation on Rabies. Second report.","year":"2013","journal-title":"World Health Organ Tech Rep Ser."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"1389-99","DOI":"10.1016\/S0140-6736(13)62707-5","article-title":"Current status of rabies and prospects for elimination.","volume":"384","author":"A Fooks","year":"2014 cited 2020 Jul 5","journal-title":"Lancet."},{"key":"ref-4","article-title":"Rabies vaccines and immunoglobulins: WHO position April 2018"},{"key":"ref-5","article-title":"National Rabies Control Programme"},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"e1847","DOI":"10.1371\/journal.pntd.0001847","article-title":"Deaths from symptomatically identifiable furious rabies in India: a nationally representative mortality survey.","volume":"6","author":"W Suraweera","year":"2012","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-7","article-title":"Second Draft Ministry of Health and Family Welfare 2 Draft National Action Plan for Eliminating Dog Mediated Rabies from India"},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"29-35","DOI":"10.1016\/j.ijid.2005.10.007","article-title":"Assessing the burden of human rabies in India: results of a national multi-center epidemiological survey.","volume":"11","author":"M Sudarshan","year":"2007 cited 2020 Jul 5","journal-title":"Int J Infect Dis."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"230","DOI":"10.2471\/BLT.14.136044","article-title":"Human rabies in India: a problem needing more attention.","volume":"92","author":"A Kole","year":"2014","journal-title":"Bull World Health Organ."},{"key":"ref-10","first-page":"S3-S8","article-title":"Appraisal of surveillance of human rabies and animal bites in seven states of India.","volume":"63","author":"M Sudarshan","year":"2019","journal-title":"Indian J Public Health."},{"key":"ref-11","first-page":"S51-3","article-title":"Background paper for developing a policy for the use of rabies biologicals and vaccination of humans in India.","volume":"63","author":"M Sudarshan","year":"2019","journal-title":"Indian J Public Health."},{"key":"ref-12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/2046-4053-4-1","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement.","volume":"4","author":"D Moher","year":"2015","journal-title":"Syst Rev."},{"key":"ref-13","article-title":"Extended Data Set: The epidemiological, humanistic and economic burden of dog-mediated rabies in India_a systematic review protocol.pdf.","author":"A Royal","year":"2020","journal-title":"figshare."},{"key":"ref-14","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s12874-020-00975-3","article-title":"How are systematic reviews of prevalence conducted? A methodological study.","volume":"20","author":"C Migliavaca","year":"2020 cited 2020 Dec 12","journal-title":"BMC Med Res Methodol."},{"key":"ref-15","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan-a web and mobile app for systematic reviews.","volume":"5","author":"M Ouzzani","year":"2016 cited 2020 Sep 29","journal-title":"Syst Rev."},{"key":"ref-16","doi-asserted-by":"publisher","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement.","volume":"6","author":"D Moher","year":"2009 cited 2020 Jul 5","journal-title":"PLoS Med."},{"key":"ref-17","article-title":"STROBE Statement-Checklist of items that should be included in reports of cohort studies"},{"key":"ref-18","article-title":"STROBE Statement-Checklist of items that should be included in reports of cross-sectional studies"},{"key":"ref-19","article-title":"Checklist for Randomized Controlled Trials Critical Appraisal tools for use in JBI Systematic Reviews"},{"key":"ref-20","doi-asserted-by":"publisher","first-page":"651-7","DOI":"10.1007\/s11136-011-9960-1","article-title":"Rating the methodological quality in systematic reviews of studies on measurement properties: A scoring system for the COSMIN checklist.","volume":"21","author":"C Terwee","year":"2012 cited 2020 Jul 5","journal-title":"Qual Life Res."},{"key":"ref-21","article-title":"CHEC list: Consensus Health Economic Criteria - Research - Maastricht University."},{"key":"ref-22","doi-asserted-by":"publisher","first-page":"f1049","DOI":"10.1136\/bmj.f1049","article-title":"Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement.","volume":"346","author":"D Husereau","year":"2013 cited 2020 Jul 5","journal-title":"BMJ."},{"key":"ref-23","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1186\/1471-2458-10-710","article-title":"Validation of population-based disease simulation models: a review of concepts and methods.","volume":"10","author":"J Kopec","year":"2010","journal-title":"BMC Public Health."},{"key":"ref-24","doi-asserted-by":"publisher","first-page":"449-79","DOI":"10.1002\/9780470712184.ch15","article-title":"Incorporating Economics Evidence.","author":"I Shemilt","year":"2008 cited 2020 Jul 5"},{"key":"ref-25","article-title":"CCEMG - EPPI-Centre Cost Converter v.1.4"},{"key":"ref-26","article-title":"10.4.3.1 Recommendations on testing for funnel plot asymmetry"},{"key":"ref-27","article-title":"Meta-analysis: publication bias Publication bias"}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/10-32\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/10-32\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/10-32\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T09:00:12Z","timestamp":1620810012000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/10-32\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,12]]},"references-count":27,"URL":"https:\/\/doi.org\/10.12688\/f1000research.28454.2","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.56133.r85248","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,12]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/10-32\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.31493.r80932, Koen K.A. Van Rompay, California National Primate Research Center, University of California, Davis, Davis, CA, USA, 17 Mar 2021, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/10-32\/v1#referee-response-80932","order":0,"name":"referee-response-80932","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Abhishek Royal<\/b>; \n<i>Posted: 13 Apr 2021<\/i>; Thanks a lot for providing your valuable comments for this articles. We have incorporated following changes as per your suggestions:  Rabies has been mentioned as an \u2018almost always fatal\u2019 disease after the onset of symptoms. &nbsp; The pre-exposure prophylaxis has been mentioned in the form of vaccination for high risk individuals. &nbsp; The participants has been mentioned to be based in India.&nbsp; &nbsp; The grammatical and spelling errors has been corrected.","URL":"https:\/\/f1000research.com\/articles\/10-32\/v2#referee-comment-6574","order":1,"name":"referee-comment-6574","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.31493.r83097, Sumon Ghosh, Infectious Diseases Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh, 13 Apr 2021, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/10-32\/v1#referee-response-83097","order":2,"name":"referee-response-83097","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Abhishek Royal<\/b>; \n<i>Posted: 13 Apr 2021<\/i>; Thanks a lot for providing your valuable comments to this article. We have incorporated following changes to the article as per your suggestions:  The modelling studies reporting the outcomes of interest will also be searched and will be included after screening for inclusion criteria. &nbsp; There is no specific timeline for the literature search. All the articles identified till the last date of literature search will be subjected to screening for inclusion criteria in this systematic review. &nbsp; The data specific to dog-bites and dog-mediated rabies will be extracted from the studies reporting data from all animal bites.","URL":"https:\/\/f1000research.com\/articles\/10-32\/v2#referee-comment-6575","order":3,"name":"referee-comment-6575","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}