{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:10:14Z","timestamp":1772169014066,"version":"3.50.1"},"reference-count":12,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T00:00:00Z","timestamp":1389744000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background:<\/ns4:bold>\n                    Basal cell carcinoma is one of the more common cancers worldwide; 2.8 million are diagnosed annually in the USA.\u00a0 However, the rate at which it metastasizes is considered very low, between 0.0028 and 0.5%.\u00a0 For those rare cases in which metastases occur, approximately one third metastasize to the lung.\u00a0\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Case:<\/ns4:bold>\n                    Presented is a 62-year-old Caucasian male with oculocutaneous albinism and a history of basal cell carcinomas occurring in multiple anatomic sites, most recently at the bilateral forearm and back.\u00a0 Surveillance PET\/CT imaging led to the discovery of no less than 30 lung nodules which were consistent with basal cell carcinoma on biopsy.\u00a0 Histological features were remarkably similar in both the primary tumor and in the metastases.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusion:<\/ns4:bold>\n                    \u00a0 An unusual case of a non-head and neck primary basal cell carcinoma metastatic to the lung was discovered on surveillance PET\/CT imaging, in a patient with oculocutaneous albinism.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.3-10.v1","type":"journal-article","created":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T05:10:02Z","timestamp":1389762602000},"page":"10","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Observation of a unique case of metastatic basal cell carcinoma found by radiographic evaluation in a patient with oculocutaneous albinism"],"prefix":"10.12688","volume":"3","author":[{"given":"Mickaila","family":"Johnston","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Whitney","family":"Winham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Massoll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerad M.","family":"Gardner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2014,1,15]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"S1-S3","DOI":"10.1016\/j.jaad.2007.08.041","article-title":"Metastatic basal cell carcinoma presention with unilateral upper extremity edema and lymphatic spread.","volume":"59","author":"A Soleymani","year":"2008","journal-title":"J Am Acad Dermatol."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"1043-1060","DOI":"10.1016\/S0190-9622(84)80334-5","article-title":"Metastatic basal cell carcinoma. Report of five cases and review of 170 cases in the literature.","volume":"10","author":"H von Domarus","year":"1984","journal-title":"J Am Acad Dermatol."},{"key":"ref-3","first-page":"176-181","article-title":"Rodent ulcer.","volume":"45","author":"C Beadles","year":"1894","journal-title":"Trans Pathol Soc Lond."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"715-719","DOI":"10.1016\/0190-9622(91)70108-E","article-title":"Metastatic basal cell carcinoma: report of twelve cases with a review of the literature.","volume":"24","author":"J Lo","year":"1991","journal-title":"J Am Acad Dermatol."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"328-335","DOI":"10.1002\/1097-0142(19940115)73:2<328::AID-CNCR2820730216>3.0.CO;2-U","article-title":"Metastatic basal cell carcinoma: report of five cases.","volume":"73","author":"S Snow","year":"1994","journal-title":"Cancer."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"86-88","DOI":"10.1097\/00000637-200044010-00016","article-title":"Metastatic spinal basal cell carcinoma: a case report and literature review.","volume":"44","author":"L Kogan","year":"2000","journal-title":"Ann Plast Surg."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"204-210","DOI":"10.1016\/j.sder.2012.08.005","article-title":"Hereditary nonmelanoma skin cancer.","volume":"31","author":"V Nikolaou","year":"2012","journal-title":"Semin Cutan Med Surg."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"299-309","DOI":"10.1684\/ejd.2011.1633","article-title":"Genetic skin disease predisposing to basal cell carcinoma.","volume":"22","author":"M Castori","year":"2012","journal-title":"Eur J Dermatol."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"866-878","DOI":"10.1002\/1097-0142(195107)4:4<866::AID-CNCR2820040424>3.0.CO;2-F","article-title":"Metastasizing basal-cell epithelioma of the skin; report of two cases.","volume":"4","author":"R Lattes","year":"1951","journal-title":"Cancer."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"1082-1084","DOI":"10.1046\/j.1524-4725.2002.02090.x","article-title":"Metastatic basal cell carcinoma presenting as unilateral axillary lymphadenopathy: report of a case and review of the literature.","volume":"28","author":"J Berlin","year":"2002","journal-title":"Dermatol Surg."},{"key":"ref-11","doi-asserted-by":"crossref","first-page":"511-519","DOI":"10.1177\/014556130007900710","article-title":"Basal cell carcinoma metastatic to the parotid: report of a new case and review of the literature.","volume":"79","author":"J Malone","year":"2000","journal-title":"Ear Nose Throat J."},{"key":"ref-12","doi-asserted-by":"publisher","first-page":"73-7","DOI":"10.1016\/0277-5379(90)90262-R","article-title":"Systemic cytotoxic therapy of basal cell carcinoma: A review of the literature.","volume":"26","author":"P Pfeiffer","year":"1990","journal-title":"Eur J Cancer."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/3-10\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/3-10\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/3-10\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T11:30:14Z","timestamp":1565091014000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/3-10\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,15]]},"references-count":12,"URL":"https:\/\/doi.org\/10.12688\/f1000research.3-10.v1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.3380.r3129","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.3380.r3317","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.3380.r3128","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.3380.r3132","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.3380.r3317","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.3380.r3128","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.3380.r3132","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.3380.r3129","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,15]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/3-10\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.3380.r3129, Amanda Mullins, Yosemite Pathology Medical Group, Emanuel Medical Centre, Turlock, CA, USA, 17 Jan 2014, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/3-10\/v1#referee-response-3129","order":0,"name":"referee-response-3129","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.3380.r3132, Jordan Reynolds, Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA, 22 Jan 2014, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/3-10\/v1#referee-response-3132","order":1,"name":"referee-response-3132","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.3380.r3128, Angela Bohlke, Dermapathology and Aesthetics, Silver Falls Dermatology, Salem, OR, USA, 23 Jan 2014, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/3-10\/v1#referee-response-3128","order":2,"name":"referee-response-3128","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.3380.r3317, Eva B. 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Costs were covered by the Department of Pathology at the University of Arkansas for Medical Sciences.","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Data associated with the article are available under the terms of the Creative Commons Zero \"No rights reserved\" data waiver (CC0 1.0 Public domain dedication).","order":0,"name":"copyright-info","label":"Copyright"}]}}