{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:10:46Z","timestamp":1791223846255,"version":"4.1.0"},"update-to":[{"DOI":"10.12688\/f1000research.3-28.v1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T00:00:00Z","timestamp":1398124800000}}],"reference-count":70,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T00:00:00Z","timestamp":1398124800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Oxidative stress is a proposed mechanism in brain aging, making the study of its regulatory processes an important aspect of current neurobiological research. In this regard, the role of the aging regulator insulin-like growth factor I (IGF-I) in brain responses to oxidative stress remains elusive as both beneficial and detrimental actions have been ascribed to this growth factor.<\/ns4:p>\n                  <ns4:p>\n                    Because astrocytes protect neurons against oxidative injury, we explored whether IGF-I participates in astrocyte neuroprotection and found that blockade of the IGF-I receptor in astrocytes abrogated their rescuing effect on neurons.\u00a0We found that IGF-I directly protects astrocytes against oxidative stress (H\n                    <ns4:sub>2<\/ns4:sub>\n                    O\n                    <ns4:sub>2<\/ns4:sub>\n                    ). Indeed, in astrocytes but not in neurons, IGF-I decreases the pro-oxidant protein thioredoxin-interacting protein 1 and normalizes the levels of reactive oxygen species. Furthermore, IGF-I cooperates with trophic signals produced by astrocytes in response to H\n                    <ns4:sub>2<\/ns4:sub>\n                    O\n                    <ns4:sub>2<\/ns4:sub>\n                    such as stem cell factor (SCF) to protect neurons against oxidative insult. After stroke, a condition associated with brain aging where oxidative injury affects peri-infarcted regions, a simultaneous increase in SCF and IGF-I expression was found in the cortex, suggesting that a similar cooperative response takes place\n                    <ns4:italic>in vivo<\/ns4:italic>\n                    . Cell-specific modulation by IGF-I of brain responses to oxidative stress may contribute in clarifying the role of IGF-I in brain aging.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.3-28.v2","type":"journal-article","created":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T12:25:22Z","timestamp":1399897522000},"page":"28","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":63,"title":["Astrocytes require insulin-like growth factor I to protect neurons against oxidative 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.4206.r4528, Marta Margeta, Department of Pathology, University of California San Francisco, San Francisco, CA, USA, 01 May 2014, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/3-28\/v2#referee-response-4528","order":0,"name":"referee-response-4528","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Ignacio Torres Aleman<\/b>; \n<i>Posted: 09 May 2014<\/i>; In response to the minor points raised by the reviewer:The symbol # in Figure 3A is missing due to a typographical error.&nbsp;We now incorporate the requested table for the experiments analyzed by 2-way ANOVA including non-significant values.","URL":"https:\/\/f1000research.com\/articles\/3-28\/v2#referee-comment-808","order":1,"name":"referee-comment-808","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.3363.r3443, Carlos Matute, Department of Neuroscience, Pa\u00eds Vasco University, Leioa, Spain, 07 Feb 2014, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/3-28\/v1#referee-response-3443","order":2,"name":"referee-response-3443","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.3363.r3862, Vince C Russo, Centre for Hormone Research, Murdoch Children\u2019s Research Institute, Parkville, VIC, Australia, 06 Mar 2014, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/3-28\/v1#referee-response-3862","order":3,"name":"referee-response-3862","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This work was funded by grants of the Spanish Ministry of Science (SAF2010-17036) and Centro Investigacion Biomedica en red Enfermedades Neurodegenerativas (CIBERNED) to IT-A. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Data associated with the article are available under the terms of the Creative Commons Zero \"No rights reserved\" data waiver (CC0 1.0 Public domain dedication).","order":0,"name":"copyright-info","label":"Copyright"}]}}