{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:10:20Z","timestamp":1772169020281,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.3-4.v1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T00:00:00Z","timestamp":1396224000000}}],"reference-count":15,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T00:00:00Z","timestamp":1396224000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    Melioidosis is endemic in areas of Southeast Asia, however, there are no published reports from the Thai-Myanmar border. We report the first two documented cases of fatal melioidosis in this region. This is of great public health importance and highlights the need to both increase clinical awareness of melioidosis on the Thai-Myanmar border, and to assess the true burden of disease in the area through improved case detection and\n                    <ns4:italic>Burkholderia pseudomallei<\/ns4:italic>\n                    prevalence studies.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.3-4.v2","type":"journal-article","created":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T12:10:07Z","timestamp":1396267807000},"page":"4","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Two fatal cases of melioidosis on the Thai-Myanmar border"],"prefix":"10.12688","volume":"3","author":[{"given":"Cindy S.","family":"Chu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart","family":"Winearls","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clare","family":"Ling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam Beer","family":"Torchinsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aung Phae","family":"Phyo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warat","family":"Haohankunnathum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Turner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanaporn","family":"Wuthiekanun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"Nosten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2014,3,31]]},"reference":[{"key":"ref-1","doi-asserted-by":"crossref","first-page":"759-61","DOI":"10.4269\/ajtmh.2002.66.759","article-title":"Short report: a rapid method for the differentiation of Burkholderia pseudomallei and Burkholderia thailandensis.","volume":"66","author":"V Wuthiekanun","year":"2002","journal-title":"Am J Trop Med Hyg."},{"key":"ref-2","first-page":"262-7","article-title":"An account of the discovery of a hitherto undescribed infective disease occurring among the population of Rangoon.","volume":"47","author":"A Whitmore","year":"1912","journal-title":"Indian Med Gaz."},{"key":"ref-3","doi-asserted-by":"crossref","first-page":"1-34.1","DOI":"10.1017\/S0022172400005234","article-title":"An Account of a Glanders-like Disease occurring in Rangoon.","volume":"13","author":"A Whitmore","year":"1913","journal-title":"J Hyg (Lond)."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"1251-75","DOI":"10.1111\/j.1348-0421.1992.tb02129.x","article-title":"Proposal of Burkholderia gen. nov. and transfer of seven species of the genus Pseudomonas homology group II to the new genus, with the type species Burkholderia cepacia (Palleroni and Holmes 1981) comb. nov.","volume":"36","author":"E Yabuuchi","year":"1992","journal-title":"Microbiol Immunol."},{"key":"ref-5","first-page":"296-9","article-title":"Morphia injectors\u2019 septicaemia.","volume":"52","author":"C Krishnaswami","year":"1917","journal-title":"Indian Med Gaz."},{"key":"ref-6","article-title":"Melioidosis: Notes on a culture of B. whitmori from Saigon. Danielsson B editor.","author":"A Stanton","year":"1932","journal-title":"J Hyg (Lond)."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"1715-22","DOI":"10.1016\/S0140-6736(03)13374-0","article-title":"Meliodosis.","volume":"361","author":"N White","year":"2003","journal-title":"Lancet."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"e2072","DOI":"10.1371\/journal.pntd.0002072","article-title":"Activities of daily living associated with acquisition of melioidosis in northeast Thailand: a matched case-control study.","volume":"7","author":"D Limmathurotsakul","year":"2013","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"653-4","DOI":"10.1086\/318713","article-title":"Meliodosis and Pandora\u2019s box in the Lao People's Democratic Republic.","volume":"32","author":"R Phetsouvanh","year":"2001","journal-title":"Clin Infect Dis."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"383-416","DOI":"10.1128\/CMR.18.2.383-416.2005","article-title":"Melioidosis: epidemiology, pathophysiology, and management.","volume":"18","author":"A Cheng","year":"2005","journal-title":"Clin Microbiol Rev."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"532-6","DOI":"10.1128\/AEM.01822-10","article-title":"Randomized soil survey of the distribution of Burkholderia pseudomallei in rice fields in Laos.","volume":"77","author":"S Rattanavong","year":"2011","journal-title":"Appl Environ Microbiol."},{"key":"ref-12","doi-asserted-by":"crossref","first-page":"458-61","DOI":"10.4269\/ajtmh.1999.60.458","article-title":"Epidemiology of Burkholderia pseudomallei in Thailand.","volume":"60","author":"V Vuddhakul","year":"1999","journal-title":"Am J Trop Med Hyg."},{"key":"ref-13","doi-asserted-by":"crossref","first-page":"945-6","DOI":"10.4269\/ajtmh.2006.75.945","article-title":"Short report: Melioidosis in Myanmar: forgotten but not gone?","volume":"75","author":"V Wuthiekanun","year":"2006","journal-title":"Am J Trop Med Hyg."},{"key":"ref-14","doi-asserted-by":"publisher","first-page":"S10-S11","DOI":"10.1016\/S0035-9203(08)70004-X","article-title":"Re-emergence of melioidosis in Myanmar.","volume":"102","author":"M Aung","year":"2008","journal-title":"Trans R Soc Trop Med Hyg."},{"key":"ref-15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61951-0","article-title":"Trimethoprim-sulfamethoxazole versus trimethoprim-sulfamethoxazole plus doxycycline as oral eradicative treatment for melioidosis (MERTH): a multicentre, double-blind, non-inferiority, randomised controlled trial.","author":"P Chetchotisakd","year":"2013","journal-title":"Lancet."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/3-4\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/3-4\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/3-4\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T15:15:58Z","timestamp":1543850158000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/3-4\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,31]]},"references-count":15,"URL":"https:\/\/doi.org\/10.12688\/f1000research.3-4.v2","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.4143.r4324","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.4143.r4323","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.4143.r4323","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.4143.r4324","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,31]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/3-4\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.3484.r2977, Kavitha Saravu, Department of Medicine, Kasturba Medical College, Manipal, India, 22 Jan 2014, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/3-4\/v1#referee-response-2977","order":0,"name":"referee-response-2977","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Cindy Chu<\/b>; \n<i>Posted: 28 Jan 2014<\/i>; Thank you for your useful comments. Our reply to your points are as follows:We agree that it would have been better had diabetes been ruled out. &nbsp;A blood sample for glycated hemoglobin was not sent to the sub-district hospitals, and was not available at our hospital. In this case, repeated random dextrose levels remained elevated with the highest measure being 520 mg\/dL. The urine dipstick results were WBC 1+, ketones 3+, glucose 1+. Serum biochemistry for K+ was 3.14 mmol\/L and for Na+ was 129.5 mmol\/L, not consistent with dehydration.&nbsp;Oral chloroquine 500 mg daily was given for 2 days. The patient expired before the final dose could be given.&nbsp;The patient's symptoms had started approximately 8 weeks before admission. She was admitted 3 days prior to her death and the case report describes the events over those 3 days.","URL":"https:\/\/f1000research.com\/articles\/3-4\/v2#referee-comment-681","order":1,"name":"referee-comment-681","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.4143.r4324, Blandine Rammaert, Service des Maladies Infectieuses et Tropicales, Necker Sick Children's Hospital, Paris, France, 10 Apr 2014, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/3-4\/v2#referee-response-4324","order":2,"name":"referee-response-4324","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.4143.r4323, Nicholas Feasey, Institute of Translational Medicine, University of Liverpool, Liverpool, UK, 02 Apr 2014, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/3-4\/v2#referee-response-4323","order":3,"name":"referee-response-4323","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"SMRU, COMRU and MORU are part of the Thailand Major Overseas Program supported by the Wellcome Trust (UK). The blood culture system at SMRU is supported by a grant from the US CDC (Project code 1U50CK000192).","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Data associated with the article are available under the terms of the Creative Commons Zero \"No rights reserved\" data waiver (CC0 1.0 Public domain dedication).","order":0,"name":"copyright-info","label":"Copyright"}]}}