{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:10:11Z","timestamp":1772169011800,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.3-58.v1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2014,6,18]],"date-time":"2014-06-18T00:00:00Z","timestamp":1403049600000}}],"reference-count":27,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2014,6,18]],"date-time":"2014-06-18T00:00:00Z","timestamp":1403049600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>We describe a patient with a rare combination of acromegaly and primary aldosteronism. A 37 year-old female patient was diagnosed with acromegaly on the basis of typical clinical, hormonal and image characteristics. She presented also with one of the most common co-morbidities \u2013 arterial hypertension. The patient has been regularly followed-up and after three surgical interventions, irradiation and adjuvant treatment with a dopamine agonist, acromegaly was finally controlled in 2008 (20 years after diagnosis). Arterial hypertension however, remained a therapeutic problem even after prescription of four antihypertensive drugs. She had normal biochemical parameters, except for low potassium levels 3.2 (3.5-5.6) mmol\/l. This raised the suspicion of primary hyperaldosteronism, confirmed by a high aldosterone to plasma rennin activity ratio, high aldosterone level after a Captopril challenge test and visualization of a 35 mm left adrenal nodule on a CT scan. After an operation, the patient recovered from hypokalemia and antihypertensive therapy was reduced to a small dose of a Ca blocker.<\/ns4:p>\n                  <ns4:p>Co-morbid arterial hypertension is common in acromegaly, though it is rare for this to be caused by Conn\u2019s adenoma. The association of Conn\u2019s adenoma with acromegaly has been interpreted in two lines: as a component of multiple endocrine neoplasia type (MEN1) syndrome or as a direct mitogenic effect of hyperactivated GH-IGF1 axis.<\/ns4:p>","DOI":"10.12688\/f1000research.3-58.v2","type":"journal-article","created":{"date-parts":[[2014,6,18]],"date-time":"2014-06-18T11:56:43Z","timestamp":1403092603000},"page":"58","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: A case report of acromegaly associated with primary aldosteronism"],"prefix":"10.12688","volume":"3","author":[{"given":"Joanna","family":"Matrozova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Vandeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabina","family":"Zacharieva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2014,6,18]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"564-570","DOI":"10.1210\/jcem.75.2.1639957","article-title":"Aldosterone-secreting adrenal adenoma as part of multiple endocrine neoplasia type 1 (MEN1): loss of heterozygosity for polymorphic chromosome 11 deoxyribonucleic acid markers, including the MEN1 locus.","volume":"75","author":"A Beckers","year":"1992","journal-title":"J Clin Endocrinol Metab."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"560-564","DOI":"10.3346\/jkms.2012.27.5.560","article-title":"A rare case of primary hyperparathyroidism associated with primary aldosteronism, Hurthle cell thyroid cancer and meningioma.","volume":"27","author":"Y Kim","year":"2012","journal-title":"J Korean Med Sci."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"310-314","DOI":"10.2169\/internalmedicine.43.310","article-title":"Primary hyperparathyroidism associatiated with aldosterone-producing adrenocortical adenoma and breast cancer: relation to MEN1 gene.","volume":"43","author":"M Honda","year":"2004","journal-title":"Intern Med."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"5658-5671","DOI":"10.1210\/jcem.86.12.8070","article-title":"Guidelines for diagnosis and therapy of MEN type 1 and type 2.","volume":"86","author":"M Brandi","year":"2001","journal-title":"J Clin Endocrinol Metab."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"269-279","DOI":"10.1530\/EJE-11-0679","article-title":"Adrenal involvement in MEN1. 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MEN1 founding mutation, clinical features, and bone mineral density profile.","volume":"159","author":"D Lourenco","year":"2008","journal-title":"Eur J Endocrinol."},{"key":"ref-13","doi-asserted-by":"publisher","first-page":"1841-1845","DOI":"10.1210\/jcem.81.5.8626844","article-title":"Prolactinomas in a large kindred with multiple endocrine neoplasia type 1: clinical features and inheritance pattern.","volume":"81","author":"J Burgess","year":"1996","journal-title":"J Clin Endocrinol Metab."},{"key":"ref-14","doi-asserted-by":"publisher","first-page":"484-494","DOI":"10.7326\/0003-4819-129-6-199809150-00011","article-title":"Multiple endocrine neoplasia type 1: clinical and genetic topics.","volume":"129","author":"S Marx","year":"1998","journal-title":"Ann Intern Med."},{"key":"ref-15","doi-asserted-by":"publisher","first-page":"653-669","DOI":"10.1093\/qjmed\/89.9.653","article-title":"Clinical studies of multiple endocrine neoplasia type 1 (MEN1).","volume":"89","author":"D 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