{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:09:47Z","timestamp":1772168987494,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.3267.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T00:00:00Z","timestamp":1401840000000}}],"reference-count":7,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T00:00:00Z","timestamp":1401840000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>We report the case of a 49-year-old male with clinical and histological findings consistent with hypertrophic lupus erythematosus (HLE). HLE must be clinically and histologically differentiated from keratoacanthoma, hypertrophic lichen planus, squamous cell carcinoma and plaque type psoriasis. CD123 positivity and transepidermal elimination of elastin have recently been reported as tools to distinguish HLE. Interestingly, in this case, biopsies of two separate lesions failed to reveal these two features. The etiology of this discrepancy is unknown and further studies are needed to clarify the utility of CD123 positivity and transepidermal elimination of elastin in the diagnosis of hypertrophic lupus erythematosus.<\/ns4:p>","DOI":"10.12688\/f1000research.3267.2","type":"journal-article","created":{"date-parts":[[2014,6,18]],"date-time":"2014-06-18T04:37:48Z","timestamp":1403066268000},"page":"76","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: A case of hypertrophic lupus erythematosus with negative CD123 staining and absence of\u00a0transepidermal elimination of elastin"],"prefix":"10.12688","volume":"3","author":[{"given":"Matthew","family":"Hughes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerad M.","family":"Gardner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2014,6,4]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"443-8","DOI":"10.1034\/j.1600-0560.2003.00082.x","article-title":"Hypertrophic lupus erythematosus: a clinicopathological study of 14 cases.","volume":"30","author":"P Daldon","year":"2003","journal-title":"J Cutan Pathol."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"889-92","DOI":"10.1111\/j.1600-0560.2011.01779.x","article-title":"Hypertrophic lupus erythematosus: the diagnostic utility of CD123 staining.","volume":"38","author":"C Ko","year":"2011","journal-title":"J Cutan Pathol."},{"key":"ref-3","first-page":"211","article-title":"Hypertrophic lupus erythematosus.","volume":"42","author":"P Bechet","year":"1940","journal-title":"Arch Dermato Syph."},{"key":"ref-4","doi-asserted-by":"crossref","first-page":"507-520","DOI":"10.1111\/j.1365-2133.1978.tb01936.x","article-title":"Verrucous lesion in patients with discoid lupus erythematosus. Clinical, histopathological and immunofluorescence studies.","volume":"98","author":"J Uitto","year":"1978","journal-title":"Br J Dermatol."},{"key":"ref-5","doi-asserted-by":"crossref","first-page":"482-6","DOI":"10.1111\/j.1346-8138.2005.tb00785.x","article-title":"Hypertrophic lupus erythematosus treated successfully with acitretin as monotherapy.","volume":"32","author":"N Al-Mutairi","year":"2005","journal-title":"J Dermatol."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"365-371","DOI":"10.1080\/09546630410018094","article-title":"Thalidomide treatment for hypertrophic cutaneous lupus erythematosus.","volume":"15","author":"D Gambini","year":"2004","journal-title":"J Dermatolog Treat."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"1007-10","DOI":"10.1177\/0961203312441982","article-title":"Response to ustekinumab in a patient with both severe psoriasis and hypertrophic cutaneous lupus.","volume":"21","author":"D Winchester","year":"2012","journal-title":"Lupus."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/3-76\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/3-76\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/3-76\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T15:05:42Z","timestamp":1543849542000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/3-76\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,4]]},"references-count":7,"aliases":["10.12688\/f1000research.4723"],"URL":"https:\/\/doi.org\/10.12688\/f1000research.3267.2","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.4723.r5015","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.4723.r5159","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.4723.r5010","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.4723.r5010","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.4723.r5015","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.4723.r5159","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,4]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/3-76\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.4723.r5010, Victoria P. Werth, Department of Dermatology, University of Pennsylvania, Philadelphia, PA, USA, 17 Jun 2014, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/3-76\/v2#referee-response-5010","order":0,"name":"referee-response-5010","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.4723.r5159, Theresa T. Lu, Autoimmunity and Inflammation Program and Pediatric Rheumatology, Hospital for Special Surgery, New York, NY, USA, 18 Jun 2014, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/3-76\/v2#referee-response-5159","order":1,"name":"referee-response-5159","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.4723.r5015, Jordan Reynolds, Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA, 05 Jun 2014, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/3-76\/v2#referee-response-5015","order":2,"name":"referee-response-5015","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Data associated with the article are available under the terms of the Creative Commons Zero \"No rights reserved\" data waiver (CC0 1.0 Public domain dedication).","order":0,"name":"copyright-info","label":"Copyright"}]}}