{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:41:50Z","timestamp":1767177710347,"version":"build-2238731810"},"reference-count":0,"publisher":"F1000 Research Ltd","content-domain":{"domain":["f1000research.com"],"crossmark-restriction":true},"short-container-title":["F1000Res"],"DOI":"10.12688\/f1000research.3848","type":"journal-article","created":{"date-parts":[[2014,2,27]],"date-time":"2014-02-27T06:08:33Z","timestamp":1393481313000},"update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Modulation of gene expression in guinea pig paraflocculus after induction of hearing loss"],"prefix":"10.12688","author":[{"given":"Wilhelmina H. A. M.","family":"Mulders","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Rodger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clarissa G.","family":"Yates","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2014,2,27]]},"updated-by":[{"DOI":"10.12688\/f1000research.4325","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000}}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/f1000research.com\/articles\/3-63\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2015,6,24]],"date-time":"2015-06-24T23:59:39Z","timestamp":1435190379000},"score":1,"resource":{"primary":{"URL":"http:\/\/f1000research.com\/articles\/3-63\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,27]]},"references-count":0,"aliases":["10.12688\/f1000research.3594.2","10.12688\/f1000research.3594.1","10.12688\/f1000research.4325"],"URL":"https:\/\/doi.org\/10.12688\/f1000research.3848","relation":{},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,27]]},"assertion":[{"value":"Approved","URL":"http:\/\/f1000research.com\/articles\/3-63\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"<b>Thomas Brozoski<\/b> Division of Otolaryngology, Southern Illinois University, Springfield, IL, USA Approved: 06 Mar 2014 (v1); I have read this submission. I believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard. ; The title and abstract are appropriate.&nbsp;Overall, the methods, results, and conclusions appear to be sound. The study contributes to our evolving understanding of the central nervous system consequences of hearing loss. The results also temper the general hypothesis that loss of peripheral hearing sensitivity leads to a loss of inhibition. Unfortunately, the actual story may be more complex than that. <b>Specific Comments:<\/b>There is a typographical error in the methods paragraph describing gene expression analysis (missing parenthesis).&nbsp;Hearing threshold data are displayed as dB loss. This is okay, but I prefer to see hearing threshold levels simply plotted as dB SPL. Elevations (loss) can then be interpreted by the reader.&nbsp;It is surprising that GABA indictors were elevated in the trauma animals, while glutamatergic indicators were not. But that is why research is done.&nbsp;It would have been informative to look at longer-term consequences of the trauma as well, and perhaps those experiments are in progress.; <b>Competing Interests:<\/b>No competing interests were disclosed.","URL":"http:\/\/f1000research.com\/articles\/3-63\/v1#referee-response-3990","order":0,"name":"referee-response-3990","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This research was supported by grants from the Royal National Institute for Deaf People (UK) G55, the Neurotrauma Research Program Western Australia, the Medical Health and Research Infrastructure Fund (WA) and The University of Western Australia.The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":1,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Data associated with the article are available under the terms of the Creative Commons Zero \"No rights reserved\" data waiver (CC0 1.0 Public domain dedication).","order":0,"name":"copyright-info","label":"Copyright"}]}}