{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:29:33Z","timestamp":1789957773152,"version":"4.0.1"},"reference-count":49,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2014,5,13]],"date-time":"2014-05-13T00:00:00Z","timestamp":1399939200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Dementia with Lewy Bodies (DLB) and Parkinson\u2019s Disease Dementia (PDD) together, represent the second most common cause of dementia, after Alzheimer\u2019s disease (AD). The synaptic dysfunctions underlying the cognitive decline and psychiatric symptoms observed throughout the development of PDD and DLB are still under investigation. In this study we examined the expression level of Dynamin1 and phospho-CaMKII, key proteins of endocytosis and synaptic plasticity respectively, as potential markers of molecular processes specifically deregulated with DLB and\/or PDD. In order to measure the levels of these proteins, we isolated grey matter from post-mortem prefrontal cortex area (BA9), anterior cingulated gyrus (BA24) and parietal cortex (BA40) from DLB and PDD patients in comparison to age-matched controls and a group of AD cases. Clinical and pathological data available included the MMSE score, neuropsychiatric history, and semi-quantitative scores for AD pathology (plaques - tangles) and for \u03b1-synuclein (Lewy bodies).<\/ns4:p>\n                  <ns4:p>Changes in the expression of the synaptic markers, and correlates with neuropathological features and cognitive decline were predominantly found in the prefrontal cortex. On one hand, levels of Dynamin1 were significantly reduced, and correlated with a higher rate of cognitive decline observed in cases from three dementia groups. On the other hand, the fraction of phospho-CaMKII was decreased, and correlated with a high score of plaques and tangles in BA9. Interestingly, the correlation between the rate of cognitive decline and the level of Dynamin1 remained when the analysis was restricted to the PDD and DLB cases, highlighting an association of Dynamin1 with cognitive decline in people with Lewy Body dementia.<\/ns4:p>","DOI":"10.12688\/f1000research.3786.1","type":"journal-article","created":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T17:25:20Z","timestamp":1403025920000},"page":"108","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Dynamin1 concentration in the prefrontal cortex is associated with cognitive impairment in Lewy body dementia"],"prefix":"10.12688","volume":"3","author":[{"given":"Julie","family":"Vallortigara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sindhoo","family":"Rangarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Whitfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amani","family":"Alghamdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4532-7990","authenticated-orcid":false,"given":"David","family":"Howlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibor","family":"Hortob\u00e1gyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Attems","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive","family":"Ballard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"O\u2019Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dag","family":"Aarsland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Francis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2014,5,13]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"445-52","DOI":"10.1159\/000165917","article-title":"Frequency and case identification of dementia with Lewy bodies using the revised consensus criteria.","volume":"26","author":"D Aarsland","year":"2008","journal-title":"Dement Geriatr Cogn Disord."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"1863-1872","DOI":"10.1212\/01.wnl.0000187889.17253.b1","article-title":"Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium.","volume":"65","author":"I McKeith","year":"2005","journal-title":"Neurology."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"812-9","DOI":"10.1212\/01.wnl.0000256715.13907.d3","article-title":"DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers.","volume":"68","author":"C Lippa","year":"2007","journal-title":"Neurology."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"187-92","DOI":"10.1159\/000017235","article-title":"Beta-amyloid deposition in the temporal lobe of patients with dementia with Lewy bodies: comparison with non-demented cases and Alzheimer\u2019s disease.","volume":"11","author":"R Armstrong","year":"2000","journal-title":"Dement Geriatr Cogn Disord."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"187-94","DOI":"10.1046\/j.1365-2990.1998.00112.x","article-title":"Amyloid beta protein (A beta) deposition in dementia with Lewy bodies: predominance of A beta 42(43) and paucity of A beta 40 compared with sporadic Alzheimer\u2019s disease.","volume":"24","author":"D Mann","year":"1998","journal-title":"Neuropathol Appl Neurobiol."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"569-77","DOI":"10.2174\/15672050113109990002","article-title":"Neuropathological correlates of cerebral multimorbidity.","volume":"10","author":"J Attems","year":"2013","journal-title":"Curr Alzheimer Res."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"791-800","DOI":"10.1093\/brain\/awh088","article-title":"Cerebral atrophy in Parkinson\u2019s disease with and without dementia: a comparison with Alzheimer\u2019s disease, dementia with Lewy bodies and controls.","volume":"127","author":"E Burton","year":"2004","journal-title":"Brain."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"1429-39","DOI":"10.1172\/JCI15777","article-title":"Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies.","volume":"110","author":"M Neumann","year":"2002","journal-title":"J Clin Invest."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"1405-1410","DOI":"10.1523\/JNEUROSCI.4564-06.2007","article-title":"Presynaptic \u03b1-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies.","volume":"27","author":"M Kramer","year":"2007","journal-title":"J Neurosci."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"239-252","DOI":"10.1016\/S0896-6273(00)80886-7","article-title":"Mice lacking \u03b1-synuclein display functional deficits in the nigrostriatal dopamine system.","volume":"25","author":"A Abeliovich","year":"2000","journal-title":"Neuron."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"4087-92","DOI":"10.1073\/pnas.1218424110","article-title":"Large \u03b1-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking.","volume":"110","author":"B Choi","year":"2013","journal-title":"Proc Natl Acad Sci U S A."},{"key":"ref-12","doi-asserted-by":"publisher","first-page":"105-117","DOI":"10.1093\/hmg\/ddn321","article-title":"Cognitive impairment in Gdi1\u2013deficient mice is associated with altered synaptic vesicle pools and short-term synaptic plasticity, and can be corrected by appropriate learning training.","volume":"18","author":"V Bianchi","year":"2009","journal-title":"Hum Mol Genet."},{"key":"ref-13","doi-asserted-by":"publisher","first-page":"572-80","DOI":"10.1002\/ana.410300410","article-title":"Physical basis of cognitive alterations in Alzheimer\u2019s disease: synapse loss is the major correlate of cognitive impairment.","volume":"30","author":"R Terry","year":"1991","journal-title":"Ann Neurol."},{"key":"ref-14","doi-asserted-by":"publisher","first-page":"126-43","DOI":"10.1007\/s12035-011-8226-9","article-title":"Synaptic protein alterations in Parkinson\u2019s disease.","volume":"45","author":"I Pienaar","year":"2012","journal-title":"Mol Neurobiol."},{"key":"ref-15","doi-asserted-by":"publisher","first-page":"483-519","DOI":"10.1146\/annurev.cellbio.16.1.483","article-title":"Dynamin and its role in membrane fission.","volume":"16","author":"J Hinshaw","year":"2000","journal-title":"Annu Rev Cell Dev Biol."},{"key":"ref-16","doi-asserted-by":"publisher","first-page":"901-914","DOI":"10.1111\/j.1471-4159.2009.06384.x","article-title":"The molecular physiology of activity-dependent bulk endocytosis of synaptic vesicles.","volume":"111","author":"E Clayton","year":"2009","journal-title":"J Neurochem."},{"key":"ref-17","doi-asserted-by":"publisher","first-page":"839-850","DOI":"10.1016\/j.devcel.2006.04.002","article-title":"Dynasore, a cell-permeable inhibitor of dynamin.","volume":"10","author":"E Macia","year":"2006","journal-title":"Dev Cell."},{"key":"ref-18","doi-asserted-by":"publisher","first-page":"570-574","DOI":"10.1126\/science.1140621","article-title":"A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis.","volume":"316","author":"S Ferguson","year":"2007","journal-title":"Science."},{"key":"ref-19","doi-asserted-by":"publisher","first-page":"644-8","DOI":"10.1073\/pnas.91.2.644","article-title":"Identification of dynamin 2, an isoform ubiquitously expressed in rat tissues.","volume":"91","author":"T Cook","year":"1994","journal-title":"Proc Natl Acad Sci U S A."},{"key":"ref-20","doi-asserted-by":"publisher","first-page":"590-607","DOI":"10.1210\/edrv-16-5-590","article-title":"Dynamin and endocytosis.","volume":"16","author":"J Liu","year":"1995","journal-title":"Endocr Rev."},{"key":"ref-21","doi-asserted-by":"crossref","first-page":"32411-7","DOI":"10.1016\/S0021-9258(18)31650-8","article-title":"Dynamin 1 antisense oligonucleotide treatment prevents neurite formation in cultured hippocampal neurons.","volume":"269","author":"E Torre","year":"1994","journal-title":"J Biol Chem."},{"key":"ref-22","doi-asserted-by":"publisher","first-page":"443-52","DOI":"10.1016\/0896-6273(95)90048-9","article-title":"Postsynaptic injection of CA2+\/CaM induces synaptic potentiation requiring CaMKII and PKC activity.","volume":"15","author":"J Wang","year":"1995","journal-title":"Neuron."},{"key":"ref-23","doi-asserted-by":"publisher","first-page":"870-3","DOI":"10.1126\/science.279.5352.870","article-title":"Autophosphorylation at Thr286 of the alpha calcium-calmodulin kinase II in LTP and learning.","volume":"279","author":"K Giese","year":"1998","journal-title":"Science."},{"key":"ref-24","doi-asserted-by":"publisher","first-page":"433-42","DOI":"10.1254\/jphs.CPJ06007X","article-title":"Molecular mechanism of neuronal plasticity: induction and maintenance of long-term potentiation in the hippocampus.","volume":"100","author":"E Miyamoto","year":"2006","journal-title":"J Pharmacol Sci."},{"key":"ref-25","doi-asserted-by":"publisher","first-page":"201-6","DOI":"10.1126\/science.1378648","article-title":"Deficient hippocampal long-term potentiation in alpha-calcium-calmodulin kinase II mutant mice.","volume":"257","author":"A Silva","year":"1992","journal-title":"Science."},{"key":"ref-26","doi-asserted-by":"publisher","first-page":"162-166","DOI":"10.1126\/science.284.5411.162","article-title":"Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation.","volume":"284","author":"K Shen","year":"1999","journal-title":"Science."},{"key":"ref-27","doi-asserted-by":"publisher","first-page":"417-420","DOI":"10.1038\/359417a0","article-title":"Synaptic vesicle-associated Ca2+\/calmodulin-dependent protein kinase II is a binding protein for synapsin I.","volume":"359","author":"F Benfenati","year":"1992","journal-title":"Nature."},{"key":"ref-28","doi-asserted-by":"publisher","first-page":"1940-2","DOI":"10.1126\/science.280.5371.1940","article-title":"Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP.","volume":"280","author":"R Blitzer","year":"1998","journal-title":"Science."},{"key":"ref-29","doi-asserted-by":"publisher","first-page":"389-404","DOI":"10.1007\/s00401-006-0127-z","article-title":"Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry.","volume":"112","author":"H Braak","year":"2006","journal-title":"Acta Neuropathol."},{"key":"ref-30","doi-asserted-by":"crossref","first-page":"479-486","DOI":"10.1212\/WNL.41.4.479","article-title":"The Consortium to Establish a Registry for Alzheimer\u2019s Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer\u2019s disease.","volume":"41","author":"S Mirra","year":"1991","journal-title":"Neurology."},{"key":"ref-31","doi-asserted-by":"publisher","first-page":"1-11","DOI":"10.1007\/s00401-011-0910-3","article-title":"National Institute on Aging-Alzheimer\u2019s Association guidelines for the neuropathologic assessment of Alzheimer\u2019s disease: a practical approach.","volume":"123","author":"T Montine","year":"2012","journal-title":"Acta Neuropathol."},{"key":"ref-32","doi-asserted-by":"crossref","first-page":"1791-1800","DOI":"10.1212\/WNL.58.12.1791","article-title":"Phases of A beta-deposition in the human brain and its relevance for the development of AD.","volume":"58","author":"D Thal","year":"2002","journal-title":"Neurology."},{"key":"ref-33","doi-asserted-by":"publisher","first-page":"189-98","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician.","volume":"12","author":"M Folstein","year":"1975","journal-title":"J Psychiatr Res."},{"key":"ref-34","doi-asserted-by":"publisher","first-page":"319-33","DOI":"10.1016\/S0896-6273(01)00285-9","article-title":"The prefrontal cortex--an update: time is of the essence.","volume":"30","author":"J Fuster","year":"2001","journal-title":"Neuron."},{"key":"ref-35","doi-asserted-by":"publisher","first-page":"635-52","DOI":"10.1007\/s00401-009-0523-2","article-title":"Staging\/typing of Lewy body related alpha-synuclein pathology: a study of the BrainNet Europe Consortium.","volume":"117","author":"I Alafuzoff","year":"2009","journal-title":"Acta Neuropathol."},{"key":"ref-36","doi-asserted-by":"publisher","first-page":"484-96","DOI":"10.1111\/j.1750-3639.2008.00147.x","article-title":"Staging of neurofibrillary pathology in Alzheimer\u2019s disease: a study of the BrainNet Europe Consortium.","volume":"18","author":"I Alafuzoff","year":"2008","journal-title":"Brain Pathol."},{"key":"ref-37","doi-asserted-by":"publisher","first-page":"939-950","DOI":"10.1111\/j.1471-4159.2006.03935.x","article-title":"Down-regulation of vesicular glutamate transporters precedes cell loss and pathology in Alzheimer\u2019s disease.","volume":"98","author":"S Kirvell","year":"2006","journal-title":"J Neurochem."},{"key":"ref-38","doi-asserted-by":"publisher","first-page":"1023-1027","DOI":"10.1016\/j.neurobiolaging.2003.09.001","article-title":"Synaptic slaughter in Alzheimer\u2019s disease.","volume":"24","author":"P Coleman","year":"2003","journal-title":"Neurobiol Aging."},{"key":"ref-39","doi-asserted-by":"publisher","first-page":"31746-53","DOI":"10.1074\/jbc.M503259200","article-title":"Beta-amyloid-induced dynamin 1 depletion in hippocampal neurons. A potential mechanism for early cognitive decline in Alzheimer disease.","volume":"280","author":"B Kelly","year":"2005","journal-title":"J Biol Chem."},{"key":"ref-40","doi-asserted-by":"publisher","first-page":"1908-17","DOI":"10.1002\/jnr.22346","article-title":"Dynamin1 depletion and memory deficits in rats treated with Abeta and cerebral ischemia.","volume":"88","author":"T Wanatabe","year":"2010","journal-title":"J Neurosci Res."},{"key":"ref-41","doi-asserted-by":"publisher","first-page":"28079-89","DOI":"10.1074\/jbc.M605081200","article-title":"beta-Amyloid-induced dynamin 1 degradation is mediated by N-methyl-D-aspartate receptors in hippocampal neurons.","volume":"281","author":"B Kelly","year":"2006","journal-title":"J Biol Chem."},{"key":"ref-42","doi-asserted-by":"publisher","first-page":"e45033","DOI":"10.1371\/journal.pone.0045033","article-title":"Dynamin 1 Regulates Amyloid Generation through Modulation of BACE-1.","volume":"7","author":"L Zhu","year":"2012","journal-title":"PLoS One."},{"key":"ref-43","doi-asserted-by":"publisher","first-page":"101-8","DOI":"10.1016\/j.brainres.2004.10.061","article-title":"The expression of calcium\/calmodulin-dependent protein kinase II-alpha in the hippocampus of patients with Alzheimer\u2019s disease and its links with AD-related pathology.","volume":"1031","author":"Y Wang","year":"2005","journal-title":"Brain Res."},{"key":"ref-44","doi-asserted-by":"crossref","first-page":"17577-83","DOI":"10.1016\/S0021-9258(18)45420-8","article-title":"Phosphorylation of tau proteins to a state like that in Alzheimer\u2019s brain is catalyzed by a calcium\/calmodulin-dependent kinase and modulated by phospholipids.","volume":"262","author":"J Baudier","year":"1987","journal-title":"J Biol Chem."},{"key":"ref-45","doi-asserted-by":"publisher","first-page":"141-8","DOI":"10.1023\/A:1006807105059","article-title":"Protein kinase C and calcium\/calmodulin-dependent protein kinase II phosphorylate three-repeat and four-repeat tau isoforms at different rates.","volume":"168","author":"T Singh","year":"1997","journal-title":"Mol Cell Biochem."},{"key":"ref-46","doi-asserted-by":"publisher","first-page":"294-9","DOI":"10.1016\/0006-8993(94)90979-2","article-title":"Calcium\/calmodulin-dependent protein kinase II immunostaining is preserved in Alzheimer\u2019s disease hippocampal neurons.","volume":"657","author":"N Simonian","year":"1994","journal-title":"Brain Res."},{"key":"ref-47","doi-asserted-by":"crossref","first-page":"1809-13","DOI":"10.1097\/01.wnr.0000185015.44563.5d","article-title":"Reduction of NR1 and phosphorylated Ca2+\/calmodulin-dependent protein kinase II levels in Alzheimer\u2019s disease.","volume":"16","author":"N Amada","year":"2005","journal-title":"Neuroreport."},{"key":"ref-48","doi-asserted-by":"publisher","first-page":"791-804","DOI":"10.1111\/j.1471-4159.2011.07447.x","article-title":"Dysregulated phosphorylation of Ca(2+)\/calmodulin-dependent protein kinase II-\u03b1 in the hippocampus of subjects with mild cognitive impairment and Alzheimer\u2019s disease.","volume":"119","author":"L Reese","year":"2011","journal-title":"J Neurochem."},{"key":"ref-49","doi-asserted-by":"publisher","DOI":"10.6084\/m9.figshare.987087","article-title":"Data for synaptic proteins expression levels and pathological scores in prefrontal cortex, anterior cingulate gyrus and parietal cortex.","author":"J Vallortigara","year":"2014","journal-title":"Figshare."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/3-108\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/3-108\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/3-108\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T12:18:38Z","timestamp":1649420318000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/3-108\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,13]]},"references-count":49,"aliases":["10.12688\/f1000research.4055"],"URL":"https:\/\/doi.org\/10.12688\/f1000research.3786.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.4055.r5607","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.4055.r7429","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.4055.r7429","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.4055.r5607","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,13]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/3-108\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.4055.r5607, Stephen M. Gentleman, Department of Medicine, Imperial College London, London, UK, 30 Sep 2014, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/3-108\/v1#referee-response-5607","order":0,"name":"referee-response-5607","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.4055.r7429, Tim Anderson, New Zealand Brain Research Institute, University of Otago, Christchurch, New Zealand, 23 Jan 2015, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/3-108\/v1#referee-response-7429","order":1,"name":"referee-response-7429","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The authors would like to express their gratitude to the Alzheimer\u2019s Society who were the principal funders and to the BUPA Foundation for additional funding for this study. Grant reference number 109 to Pr P. Francis as lead investigator. Mary Johnson is funded by a grant from the Dunhill Medical Trust (R173\/1110). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Data associated with the article are available under the terms of the Creative Commons Zero \"No rights reserved\" data waiver (CC0 1.0 Public domain dedication).","order":0,"name":"copyright-info","label":"Copyright"}]}}