{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:09:06Z","timestamp":1772168946023,"version":"3.50.1"},"reference-count":24,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2014,7,22]],"date-time":"2014-07-22T00:00:00Z","timestamp":1405987200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:italic>Streptococcus agalactiae<\/ns4:italic>\n                    (group B\n                    <ns4:italic>Streptococcus<\/ns4:italic>\n                    , GBS) usually colonizes the gastrointestinal and lower genital tracts of asymptomatic hosts, yet the incidence of invasive disease is on the rise\n                    <ns4:italic>.<\/ns4:italic>\n                    We describe a case of an 18 year old woman, recently diagnosed with lupus, who reported a spontaneous abortion six weeks prior to her hospitalization.\u00a0 She presented with fever, altered mental status, and meningeal signs, paired with a positive blood culture for GBS. Magnetic resonance imaging of her brain demonstrated an extra-axial fluid collection, and she was diagnosed with meningitis.\u00a0 She received prolonged intravenous antibiotic therapy and aggressive treatment for lupus, leading to clinical recovery. This case illustrates the importance of recognizing GBS as a potential pathogen in all patients presenting with CNS infection\n                    <ns4:italic>.\u00a0\u00a0<\/ns4:italic>\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.4651.1","type":"journal-article","created":{"date-parts":[[2014,7,22]],"date-time":"2014-07-22T09:30:02Z","timestamp":1406021402000},"page":"167","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Group B Streptococcus meningitis in an adolescent\u00a0"],"prefix":"10.12688","volume":"3","author":[{"given":"Roselle","family":"Vittorino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joyce","family":"Hui-Yuen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam J.","family":"Ratner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Starr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"McCann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2014,7,22]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"895-901","DOI":"10.1007\/s10067-006-0424-x","article-title":"Clinical features, prognostic and risk factors of central nervous system infections in patients with systemic lupus erythematosus.","volume":"26","author":"C Yang","year":"2007","journal-title":"Clin Rheumatol."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"168-173","DOI":"10.1007\/s10096-003-1098-9","article-title":"Group B streptococcal disease in nonpregnant adults: incidence, clinical characteristics, and outcome.","volume":"23","author":"D Blancas","year":"2004","journal-title":"Eur J Clin Microbiol Infect Dis."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"85-92","DOI":"10.1086\/599369","article-title":"Increasing burden of invasive group B streptococcal disease in nonpregnant adults, 1990\u20132007.","volume":"49","author":"T Skoff","year":"2009","journal-title":"Clin Infect Dis."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"E23-E25","DOI":"10.1086\/317456","article-title":"Group B streptococcal meningitis complicating elective abortion: report of 2 cases.","volume":"31","author":"P Deziel","year":"2000","journal-title":"Clin Infect Dis."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"275-278","DOI":"10.1155\/S1064744995000172","article-title":"Group B streptococcus meningitis following elective termination of pregnancy: two case reports.","volume":"2","author":"M Walker","year":"1995","journal-title":"Infect Dis Obstet 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Recomm Rep."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"707-18","DOI":"10.1016\/S0022-3476(73)80604-3","article-title":"Group B streptococcal neonatal and infant infections.","volume":"82","author":"R Franciosi","year":"1973","journal-title":"J Pediatr."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"114-123","DOI":"10.1093\/cid\/cir325","article-title":"Incidence and severity of invasive Streptococcus pneumoniae, group A Streptococcus, and group B Streptococcus infections among pregnant and postpartum women.","volume":"53","author":"M Deutscher","year":"2011","journal-title":"Clin Infect Dis."},{"key":"ref-12","doi-asserted-by":"publisher","first-page":"2056-2065","DOI":"10.1001\/jama.299.17.2056","article-title":"Epidemiology of invasive group B streptococcal disease in the United States, 1999\u20132005.","volume":"299","author":"C Phares","year":"2008","journal-title":"JAMA."},{"key":"ref-13","doi-asserted-by":"publisher","first-page":"1180-1187","DOI":"10.1086\/516094","article-title":"Group B streptococcal meningitis in adults: report of twelve cases and review.","volume":"25","author":"P Domingo","year":"1997","journal-title":"Clin Infect Dis."},{"key":"ref-14","doi-asserted-by":"publisher","first-page":"195-198","DOI":"10.1111\/j.1447-0756.2007.00495.x","article-title":"Mother with post-partum group B Streptococcus meningitis and cerebellar abscess.","volume":"33","author":"N Ghani","year":"2007","journal-title":"J Obstet Gynaecol Res."},{"key":"ref-15","doi-asserted-by":"publisher","first-page":"387-388","DOI":"10.1056\/NEJM197402142900709","article-title":"Group B beta-hemolytic streptococcal meningitis in mother and infant.","volume":"290","author":"J Grossman","year":"1974","journal-title":"N Engl J Med."},{"key":"ref-16","doi-asserted-by":"publisher","first-page":"151-153","DOI":"10.1016\/S0163-4453(97)92528-7","article-title":"Streptococcus B meningitis in post-partum.","volume":"34","author":"J Guerin","year":"1997","journal-title":"J Infect."},{"key":"ref-17","first-page":"79","article-title":"Maternal group B streptococcal meningitis in the postpartum period.","volume":"23","author":"N Ravindranth","year":"2003","journal-title":"J Obstet Gynaecol."},{"key":"ref-18","doi-asserted-by":"publisher","first-page":"597-600","DOI":"10.1055\/s-2007-994076","article-title":"Fatal maternal beta-hemolytic group B streptococcal meningitis: a case report.","volume":"15","author":"R Wolfe","year":"1998","journal-title":"Am J Perinatol."},{"key":"ref-19","doi-asserted-by":"publisher","first-page":"564-71","DOI":"10.1177\/0961203307078971","article-title":"Neuropsychiatric involvement in pediatric systemic lupus erythematosus.","volume":"16","author":"S Benseler","year":"2007","journal-title":"Lupus."},{"key":"ref-20","doi-asserted-by":"publisher","first-page":"997-1000","DOI":"10.1177\/0961203307083175","article-title":"Disease activity, damage and survival in Mexican patients with acute severe systemic lupus erythematosus.","volume":"16","author":"A Zonana-Nacach","year":"2007","journal-title":"Lupus."},{"key":"ref-21","doi-asserted-by":"publisher","first-page":"531-536","DOI":"10.1177\/0961203310384495","article-title":"Meningitis in Korean patients with systemic lupus erythematosus: analysis of demographics, clinical features and outcomes; experience from affiliated hospitals of the Catholic University of Korea.","volume":"20","author":"J Kim","year":"2011","journal-title":"Lupus."},{"key":"ref-22","doi-asserted-by":"publisher","first-page":"442-449","DOI":"10.1016\/j.clim.2013.08.009","article-title":"Major infections in a cohort of 120 patients with juvenile-onset systemic lupus erythematosus.","volume":"149","author":"P Costa-Reis","year":"2013","journal-title":"Clin Immunol."},{"key":"ref-23","doi-asserted-by":"publisher","first-page":"1274-1275","DOI":"10.1111\/j.1468-3083.2007.02167.x","article-title":"An unusual complication of systemic lupus erythematosus: bacterial meningitis caused by Streptococcus agalactiae.","volume":"21","author":"B Kim","year":"2007","journal-title":"J Eur Acad Dermatol Venereol."},{"key":"ref-24","doi-asserted-by":"publisher","first-page":"1011-1015","DOI":"10.1007\/s00404-013-3088-1","article-title":"Expectant versus surgical management of first-trimester miscarriage: a randomised controlled study.","volume":"289","author":"W Al-Ma\u2019ani","year":"2014","journal-title":"Arch Gynecol Obstet."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/3-167\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/3-167\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/3-167\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T14:50:56Z","timestamp":1543848656000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/3-167\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,22]]},"references-count":24,"URL":"https:\/\/doi.org\/10.12688\/f1000research.4651.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.4972.r5871","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.4972.r5546","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.4972.r5546","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.4972.r5871","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,22]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/3-167\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.4972.r5546, Theresa T. Lu, Department of Microbiology and Immunology, Weill Cornell Medical Center, New York, NY, USA, 04 Aug 2014, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/3-167\/v1#referee-response-5546","order":0,"name":"referee-response-5546","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.4972.r5871, Rebecca Madan, Department of Pediatrics, Yeshiva University, Bronx, NY, USA, 10 Oct 2014, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/3-167\/v1#referee-response-5871","order":1,"name":"referee-response-5871","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Data associated with the article are available under the terms of the Creative Commons Zero \"No rights reserved\" data waiver (CC0 1.0 Public domain dedication).","order":0,"name":"copyright-info","label":"Copyright"}]}}