{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:08:40Z","timestamp":1772168920720,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.4671.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2014,8,20]],"date-time":"2014-08-20T00:00:00Z","timestamp":1408492800000}}],"reference-count":19,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2014,8,20]],"date-time":"2014-08-20T00:00:00Z","timestamp":1408492800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Objectives:<\/ns4:bold>\n                    To report the burden and cost of actinic keratosis (AK) treatment in Australia and to forecast the number of AK treatments and the associated costs to 2020.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Design and setting:<\/ns4:bold>\n                    A retrospective study of data obtained from medicare Australia for AK treated by cryotherapy between 1 January 1994 and 31 December 2012, by year and by state or territory.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Results:<\/ns4:bold>\n                    The total number of AK cryotherapy treatments increased from 247,515 in 1994 to 643,622 in 2012, and we estimate that the number of treatments will increase to 831,952 (95% CI 676,919 to 986,987) by 2020. The total Medicare Benefits Schedule (MBS) benefits paid out for AK in 2012 was $19.6 million and we forecast that this will increase to $24.7 million by 2020 (without inflation).\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusion:<\/ns4:bold>\n                    The number of AK cryotherapy treatments increased by 160% between 1994 and 2012. we forecast that the number of treatments will increase by 30% between 2012 and 2020. The rates of non-melanoma skin cancer (NMSC) and AK appear to be increasing at the same rate. During the period 2010 to 2015 AK is anticipated to increase by 17.8% which follows a similar trend to published data that forecasts an increase in NMSC treatments of 22.3%.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.4671.2","type":"journal-article","created":{"date-parts":[[2014,8,20]],"date-time":"2014-08-20T12:15:16Z","timestamp":1408536916000},"page":"184","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Cost for the treatment of actinic keratosis on the rise in Australia"],"prefix":"10.12688","volume":"3","author":[{"given":"Eshini","family":"Perera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"McGuigan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6751-1428","authenticated-orcid":false,"given":"Rodney","family":"Sinclair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2014,8,20]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"451-64","DOI":"10.2165\/00019053-200927060-00002","article-title":"Pharmacoeconomic considerations in treating actinic keratosis.","volume":"27","author":"M Neidecker","year":"2009","journal-title":"Pharmacoeconomics."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"1033-39","DOI":"10.1046\/j.1365-2133.1998.02560.x","article-title":"The prevalence and determinants of solar keratoses at a subtropical latitude (Queensland, Australia).","volume":"139","author":"C Frost","year":"1998","journal-title":"Br J Dermatol."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"1147-51","DOI":"10.1056\/NEJM199310143291602","article-title":"Reduction of solar keratoses by regular sunscreen use.","volume":"329","author":"S Thompson","year":"1993","journal-title":"N Engl J Med."},{"key":"ref-4","article-title":"Actinic Keratosis","author":"C Scarfe","year":"2002"},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"502-518","DOI":"10.1111\/bjd.12420","article-title":"The Natural History of Actinic Keratosis: A Systematic Review.","volume":"169","author":"R Werner","year":"2013","journal-title":"Br J Dermatol."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"CD004415","DOI":"10.1002\/14651858.CD004415.pub2","article-title":"Interventions for actinic keratoses.","volume":"12","author":"A Gupta","year":"2012","journal-title":"Cochrane Database Syst Rev."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"513-9","DOI":"10.1111\/j.1365-2133.2000.03703.x","article-title":"Incidence of skin cancer in 5356 patients following organ transplantation.","volume":"143","author":"B Lindelof","year":"2000","journal-title":"Br J Dermatol."},{"key":"ref-8","first-page":"S1-8","article-title":"Actinic keratoses: sequelae and treatments. Recommendations from a consensus panel.","volume":"55","author":"B Berman","year":"2006","journal-title":"J Fam Pract."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"687-92","DOI":"10.1111\/j.1365-4632.2004.02056.x","article-title":"A prospective study of the use of cryosurgery for the treatment of actinic keratoses.","volume":"43","author":"K Thai","year":"2004","journal-title":"Int J Dermatol."},{"key":"ref-10","article-title":"Medicare Benefits Schedule item statistics reports","year":"2013"},{"key":"ref-11","article-title":"Inflation calculator","year":"2013"},{"key":"ref-12","doi-asserted-by":"crossref","first-page":"659-672","DOI":"10.1111\/j.2517-6161.1995.tb02054.x","article-title":"Maximum Likelihood Estimation of the Differencing Parameter for Invertible Short and Long Memory Autoregressive Integrated Moving Average Models.","volume":"57","author":"J Beran","year":"1995","journal-title":"J R Statist Soc B."},{"key":"ref-13","doi-asserted-by":"publisher","first-page":"297-307","DOI":"10.1093\/biomet\/76.2.297","article-title":"Regression and time series model selection in small samples.","volume":"76","author":"C Hurvich","year":"1989","journal-title":"Biometrika."},{"key":"ref-14","doi-asserted-by":"publisher","first-page":"565-68","DOI":"10.5694\/mja12.10654","article-title":"Non-melanoma skin cancer in Australia.","volume":"197","author":"M Fransen","year":"2012","journal-title":"Med J Aust."},{"key":"ref-15","article-title":"Pharmaceutical Benefits Schedule Item Reports","year":"2013"},{"key":"ref-16","article-title":"Regional statistics, Northern Territory","year":"2013"},{"key":"ref-17","article-title":"Cancer in Australia: an overview, 2008","year":"2013"},{"key":"ref-18","article-title":"Rural, regional and remote health: a guide to remoteness classifications","year":"2013"},{"key":"ref-19","first-page":"S1-8","article-title":"Actinic keratoses: sequelae and treatments. Recommendations from a consensus panel.","volume":"55","author":"B Berman","year":"2006","journal-title":"J Fam Pract."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/3-184\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/3-184\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/3-184\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T14:13:19Z","timestamp":1717251199000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/3-184\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,20]]},"references-count":19,"URL":"https:\/\/doi.org\/10.12688\/f1000research.4671.2","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.5487.r5917","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.5487.r5918","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.5487.r5918","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.5487.r5917","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,20]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/3-184\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.5487.r5918, Luigi Naldi, Department of Dermatology, Centro Studi GISED, Bergamo, Italy, 25 Sep 2014, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/3-184\/v2#referee-response-5918","order":0,"name":"referee-response-5918","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.5487.r5917, Giuseppe Argenziano, Department of Dermatology, Second University of Naples, Naples, Italy, 01 Sep 2014, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/3-184\/v2#referee-response-5917","order":1,"name":"referee-response-5917","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Data associated with the article are available under the terms of the Creative Commons Zero \"No rights reserved\" data waiver (CC0 1.0 Public domain dedication).","order":0,"name":"copyright-info","label":"Copyright"}]}}