{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:09:49Z","timestamp":1772168989722,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.50909.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000}}],"reference-count":20,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Appendiceal cancer is rare and is often diagnosed\u00a0incidentally in patients undergoing appendectomy for acute appendicitis.\u00a0However, patients with appendiceal cancer are\u00a0at\u00a0increased risk of synchronous\u00a0malignancy.\u00a0In this\u00a0case\u00a0report, we\u00a0present a 58-year-old man\u00a0initially diagnosed\u00a0with acute appendicitis\u00a0after presenting to the emergency department with abdominal pain.\u00a0He had an appendectomy and was discharged the following day.\u00a0Unexpectedly, the postoperative\u00a0histopathologic\u00a0examination\u00a0showed\u00a0a primary\u00a0adenocarcinoma in the appendix.\u00a0A computed tomography\u00a0scan showed rectal wall thickening and the patient was\u00a0referred\u00a0to\u00a0colonoscopy where\u00a0an experienced\u00a0endoscopist\u00a0found\u00a0a\u00a0rectal\u00a0tumor\u00a0during the\u00a0digital\u00a0rectal\u00a0examination\u00a0prior to the colonoscopy.\u00a0The tumor was initially missed\u00a0by the\u00a0newly\u00a0qualified\u00a0doctor\u00a0who examined the patient\u00a0during\u00a0his\u00a0first\u00a0admittance\u00a0to\u00a0hospital.\u00a0The patient\u2019s two primary cancers were\u00a0treated with\u00a0a\u00a0laparoscopic right\u00a0hemicolectomy\u00a0for the appendiceal\u00a0cancer\u00a0and\u00a0a\u00a0low\u00a0anterior\u00a0resection\u00a0for the rectal cancer.\u00a0This\u00a0case supports the importance of a full colorectal\u00a0workup in patients with appendiceal\u00a0cancer.\u00a0It\u00a0also emphasizes the value of a thorough\u00a0digital rectal examination and the need for improved focus on teaching and practice of the procedure.<\/ns4:p>","DOI":"10.12688\/f1000research.50909.2","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T11:00:09Z","timestamp":1646305209000},"page":"152","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: The importance of\u00a0examining\u00a0colon and rectum in patients with appendiceal 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.121500.r126141, Susanne Merkel, Department of Surgery, Friedrich-Alexander-University Erlangen, Erlangen, 04 Mar 2022, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/10-152\/v2#referee-response-126141","order":0,"name":"referee-response-126141","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.121500.r126142, Cemil Y\u00fcksel, Department of Surgical Oncology, University of Health Science, Ankara Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara, 17 Mar 2022, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/10-152\/v2#referee-response-126142","order":1,"name":"referee-response-126142","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.54002.r91612, Wilhelm Graf, Department of Surgical Sciences, Uppsala University, Uppsala, 09 Sep 2021, version 1, 3 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/10-152\/v1#referee-response-91612","order":2,"name":"referee-response-91612","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Hugin Reistrup<\/b>; \n<i>Posted: 17 Feb 2022<\/i>; Dear Wilhelm Graf,  Thank you for your valuable comments, which we have read with great interest. We have answered your comments in a point-to-point format.  1) In the introduction it is stated that these tumors might present as bowel obstruction but in reality this is not true since the appendix is not in the GI passage.  Reply: We agree that this is an unlikely event, but although rare, bowel obstruction due to appendiceal neoplasm has been well described in the literature. We have also referred to a reference in the manuscript to back up this statement.  2) The MTD conference should be added to the timeline figure.  Reply: This is a very good point. We have now elaborated the decisions taken at the MDT conferences to the timeline figure.  3) Please state the body temperature, pulse and blood pressure.  Reply: We have now added this information to the \u201cCase presentation\u201d section.  4) Give more details of the MRI exam.  Reply: Unfortunately, there is no further information available on the MRI exam.  5) The listing of possible findings on DRE in the discussion could be shortened and focused just on malignant findings.  Reply: We fully understand your point regarding this. An important message in this study is to highlight the importance of a sufficient DRE. Also, we want to illustrate that the DRE can help diagnose a lot of different conditions, both benign and malign. Hence, we have chosen to make a comprehensive list of these conditions to underline this important point to the reader. As this case also has an educational aim, we are convinced that it is important to show the vast diagnostic benefits of this simple exam.  We hope that you find the comments and additions above to the manuscript sufficient.","URL":"https:\/\/f1000research.com\/articles\/10-152\/v2#referee-comment-7834","order":3,"name":"referee-comment-7834","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}