{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:08:39Z","timestamp":1772168919220,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.51208.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000}}],"reference-count":45,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005888","name":"Medical University of Lodz","doi-asserted-by":"crossref","award":["503\/6-077-01\/503-61-002"],"award-info":[{"award-number":["503\/6-077-01\/503-61-002"]}],"id":[{"id":"10.13039\/501100005888","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    <ns3:bold>Background:<\/ns3:bold>\n                    Methods which potentially could prevent age-related loss of muscle mass and function are still being sought. There are various attempts to use pharmacological agents to prevent loss of muscle mass, but the effectiveness of many of them still needs to be confirmed. One of the promising therapeutics are Angiotensin Converting Enzyme Inhibitors (ACEIs) and lowering of serum ACE activity. The goal of this study was to assess if taking Angiotensin Converting Enzyme Inhibitors (ACEI) and other angiotensin system blocking medications (ASBMs) can modify muscle performance in older men as well as to assess the association of serum ACE activity with muscle strength, power, muscle contraction velocity and functional performance.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Methods:<\/ns3:bold>\n                    Seventy-nine older men took part in the study. Muscle function was assessed with hand grip strength, maximum power relative to body mass (Pmax) and optimal shortening velocity (\u01b2opt) of the knee extensor muscles. Anthropometric data, ACE activity and functional performance were also measured.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Results:<\/ns3:bold>\n                    Negative correlations between ACE activity and Pmax (rho=-0.29, p=0.04) as well as \u01b2opt\u00a0 (rho=-0.31, p=0.03) in a group of patients not taking ACEI and between ACE activity and \u01b2opt (rho=-0.22, p=0.05) in the whole group of men were found. Positive relationship between age and ACE activity was demonstrated (rho=0.26, p=0.02). Age was the only selected variable in the multiple regression analyses to determine both Pmax and \u01b2opt.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Conclusions:<\/ns3:bold>\n                    Serum ACE activity negatively associates to muscle power and muscle contraction velocity. The issues related to the impact of taking ACEI on the maintenance of muscle function and functional performance in older man require further studies.\n                  <\/ns3:p>","DOI":"10.12688\/f1000research.51208.2","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T11:45:32Z","timestamp":1623239132000},"page":"184","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Quadriceps muscle power and optimal shortening velocity are inversely related to angiotensin converting enzyme activity in older men"],"prefix":"10.12688","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6256-1669","authenticated-orcid":false,"given":"Joanna","family":"Kostka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Sikora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Guligowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Kostka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2021,6,9]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"1594-1599","DOI":"10.1016\/j.apmr.2007.11.061","article-title":"Potential role of optimal velocity as a qualitative factor of physical functional performance in women aged 72 to 96 years.","volume":"89","author":"M 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Kostka","year":"2021","journal-title":"Zenodo."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/10-184\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/10-184\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/10-184\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T05:35:22Z","timestamp":1626413722000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/10-184\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,9]]},"references-count":45,"URL":"https:\/\/doi.org\/10.12688\/f1000research.51208.2","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.57350.r87203","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.57350.r87203","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,9]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/10-184\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.54351.r81534, Ida Wiszomirska, Faculty of Rehabilitation, J\u00f3zef Pi\u0142sudski University of Physical Education, Warsaw, Poland, 29 Mar 2021, version 1, 1 approved, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/10-184\/v1#referee-response-81534","order":0,"name":"referee-response-81534","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Joanna Kostka<\/b>; \n<i>Posted: 28 May 2021<\/i>; Dear Reviewer, We would like to thank you for the analysis of this manuscript and your valuable remarks. The manuscript has been corrected according to the comments. All changes are described&nbsp; below.  \n<b>1.<\/b>&nbsp;\n<i>One sentence requires an explanation: &quot;Taking ACEI as well as the ACE genotype with insertion (II) of allele in gene, is associated with lower serum ACE activity and with predispositions for practicing some sports.&quot; \u2013 there is no evidence, that taking ACEI is associated with predispositions for practicing some sports (in fact, there are some reports about the ACE genotype) - this sentence suggests such a relationship. Please formulate this sentence in a different way.<\/i>  \n<b>Answer:&nbsp;<\/b>This sentence was modified to: \u201cTaking ACEI as well as the ACE genotype with insertion (II) of allele in gene, is associated with lower serum ACE activity\n<sup>8,9<\/sup>. There are suggestions that the ACE genotype type predisposes one to be successful in certain sports\n<sup>10<\/sup>.\u201d  \n<b>2<\/b>.\n<i>&nbsp;Methodology Please add &quot;for each hand separately&quot; to the sentence &quot;A better record was used for analysis&quot; (last sentence of the section &quot;Muscle strength&quot;).<\/i>  \n<b>Answer:&nbsp;<\/b>We have added this sentence in line with the Reviewer's comment.  \n<b>3<\/b>.&nbsp;\n<i>Despite the reference to the literature, in this part it is worth describing the measurement of Pmax and \u01b2opt in a little more detail.<\/i>  \n<b>Answer:&nbsp;<\/b>The description of the Pmax and \u01b2opt measurement methodology has been supplemented: \u201cMuscle power and optimal shortening velocity evaluations were performed with especially prepared ergometer (Monark type 818E Stockholm, Sweden), during two 8-second attempts to pedal at the maximum possible speed with friction loads of 0.25 N&middot;kg\n<sup>\u22121<\/sup> and 0.35 N&middot;kg\n<sup>\u22121<\/sup> of body mass. Instantaneous pedaling velocity (\u01b2), force (F) and power output (P) were calculated each 5ms and then averaged over each downstroke period. The highest value of P (maximal short-term power \u2013 Pmax) and optimal shortening velocity (\u01b2opt - velocity at which the power reaches a maximum value) were calculated from a 3rd order polynomial function. The methodology \u2026\u201d  \n<b>4.&nbsp;<\/b>\n<i>Discussion In this section, it is worth discussing the limitations of the study.<\/i>  \n<b>Answer:&nbsp;<\/b>A &quot;limitation of the study&quot; section was added to the discussion.  Best regards Joanna Kostka","URL":"https:\/\/f1000research.com\/articles\/10-184\/v2#referee-comment-6730","order":1,"name":"referee-comment-6730","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.57350.r87203, Christophe A. Hautier, Laboratoire Interuniversitaire de Biologie de la Motricit\u00e9, Universit\u00e9 Claude Bernard Lyon 1, Villeurbanne, France, 16 Jul 2021, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/10-184\/v2#referee-response-87203","order":2,"name":"referee-response-87203","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This study was funded by Medical University of Lodz (grant number: 503\/6-077-01\/503-61-002 for Department of Geriatrics). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}