{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:50:35Z","timestamp":1787021435203,"version":"build-2736575974"},"update-to":[{"DOI":"10.12688\/f1000research.51845.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000}},{"DOI":"10.12688\/f1000research.51845.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000}}],"reference-count":63,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Orofacial pain represents\u00a0a challenge\u00a0for dentists, especially if it does not have an odontogenic origin.\u00a0Orofacial neuropathic pain may be chronic,\u00a0is arduous to localize and may develop without obvious pathology.\u00a0Comorbid psychiatric disorders,\u00a0such\u00a0as anxiety and depression,\u00a0coexist and negatively affect this condition.\u00a0This\u00a0article presents one case of atypical odontalgia and one of trigeminal neuralgia\u00a0treated\u00a0with\u00a0psychological and psychopharmacological\u00a0tailored\u00a0and adapted\u00a0therapies, after\u00a0conventional medications\u00a0had failed. Additionally,\u00a0an overview of\u00a0the pathologies related to the challenging differential diagnosis in orofacial pain\u00a0is given.\u00a0<\/ns4:p>\n                  <ns4:p>A\u00a068-year-old man\u00a0complained\u00a0of\u00a0chronic\u00a0throbbing and\u00a0burning pain in a maxillary tooth, which worsened upon digital pressure.\u00a0Symptoms\u00a0did not abate\u00a0after amitriptyline therapy;\u00a0psychological\u00a0intervention\u00a0along with\u00a0antianxiety drug were supplemented\u00a0and\u00a0antidepressant\u00a0agent dosage\u00a0were incremented. The patient reported improvement\u00a0and\u00a0satisfaction\u00a0with\u00a0the multidisciplinary approach to his pathology.<\/ns4:p>\n                  <ns4:p>A\u00a072-year-old man complained of\u00a0chronic\u00a0stabbing, intermittent,\u00a0sharp, shooting\u00a0and\u00a0electric shock-like\u00a0pain in an upper tooth, radiating and following\u00a0the distribution\u00a0of the trigeminal nerve.\u00a0Pain did not recur after\u00a0psychological intervention\u00a0and a prescription of antidepressant and\u00a0antianxiety agents, while carbamazepine therapy\u00a0had\u00a0not\u00a0been\u00a0sufficient to control\u00a0pain.\u00a0Due to\u00a0concerns with\u00a0comorbid psychiatric disorders, we adopted a\u00a0patient-centered,\u00a0tailored and balanced therapy, favorably changing\u00a0clinical\u00a0outcomes.<\/ns4:p>\n                  <ns4:p>Comorbid psychiatric disorders have a negative impact on orofacial pain, and dentists should consider adopting tailored therapies, such as psychological counselling and behavioral and psychopharmacologic strategies, besides conventional treatments. They also must be familiar with the signs and symptoms of orofacial pain, obtaining a comprehensive view of the pathologies concerning the differential diagnosis. A prompt diagnosis may prevent pain chronicity, avoiding an increase in complexity and a shift to orofacial neuropathic pain and legal claims.<\/ns4:p>","DOI":"10.12688\/f1000research.51845.3","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T12:20:55Z","timestamp":1656332455000},"page":"317","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Atypical odontalgia and trigeminal neuralgia: psychological, behavioral and psychopharmacological approach in a dental clinic \u2013 an overview of pathologies related to the challenging differential diagnosis in orofacial pain"],"prefix":"10.12688","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1578-3485","authenticated-orcid":false,"given":"Riccardo","family":"Tizzoni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Tizzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo Alfredo","family":"Clerici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2022,6,27]]},"reference":[{"key":"ref1","first-page":"542-6","article-title":"Diagnostic challenges of neuropathic tooth pain.","volume":"70","author":"M Matwychuk","year":"2004 Sep","journal-title":"J Can Dent Assoc."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"269-75","DOI":"10.18926\/AMO\/52895","article-title":"Chronic orofacial pain in dental patients: Retrospective investigation over 12 years.","volume":"68","author":"Y Tomoyasu","year":"2014","journal-title":"Acta Med Okayama."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"147-50","DOI":"10.1016\/j.jormas.2017.03.004","article-title":"Neuropathic pain in the orofacial region: The role of pain history. 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.135396.r142451, Joanna M. Zakrzewska, UCLH NHS Foundation Trust, UCL\/UCLH NIHR Biomedical Research Centre, London, UK, 26 Jul 2022, version 3, indexed","URL":"https:\/\/f1000research.com\/articles\/10-317\/v3#referee-response-142451","order":0,"name":"referee-response-142451","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.77676.r97183, Giulia Di Stefano, Department of Human Neuroscience, Sapienza University, Rome, Italy, 25 Oct 2021, version 2, 1 approved, 2 not approved","URL":"https:\/\/f1000research.com\/articles\/10-317\/v2#referee-response-97183","order":1,"name":"referee-response-97183","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Riccardo Tizzoni<\/b>; \n<i>Posted: 25 Oct 2021<\/i>; Dear Prof. Di Stefano we thank you very very much indeed. Your reviewing process stimulated us to ameliorate the manuscript, amending it following your precious suggestions. Thank you! We send you our Best Regards.  Riccardo Tizzoni, Marta Tizzoni and Carlo Alfredo Clerici","URL":"https:\/\/f1000research.com\/articles\/10-317\/v3#referee-comment-7345","order":2,"name":"referee-comment-7345","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.135396.r142449, Claudia Sommer, Department of Neurology, University of W\u00fcrzburg, W\u00fcrzburg, Germany, 01 Aug 2022, version 3, indexed","URL":"https:\/\/f1000research.com\/articles\/10-317\/v3#referee-response-142449","order":3,"name":"referee-response-142449","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Riccardo Tizzoni<\/b>; \n<i>Posted: 02 Sep 2022<\/i>; Dear Prof. Claudia Sommer,  We thank you very much indeed&nbsp;for the entire reviewing process of our article. We took into great consideration your valuable suggestions to amend the article.  Thank you very much,  I send my Best Regards Riccardo Tizzoni","URL":"https:\/\/f1000research.com\/articles\/10-317\/v3#referee-comment-8717","order":4,"name":"referee-comment-8717","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":5,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}