{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:24:14Z","timestamp":1767176654059,"version":"build-2238731810"},"update-to":[{"DOI":"10.12688\/f1000research.53036.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000}}],"reference-count":18,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    Tuberculosis is a major public health problem worldwide. Tuberculosis can be confused with other\u00a0diseases and its diagnosis is frequently delayed, especially in areas of low prevalence.\u00a0Abdominal tuberculosis includes involvement of the gastrointestinal tract, peritoneum, lymph nodes, and\/or solid organs; and accounts for 5% of all cases of tuberculosis. We report\u00a0two cases\u00a0of young patients\u00a0who presented preoperatively as acute abdomen due to acute appendicitis.\u00a0During surgery, these\u00a0cases\u00a0were\u00a0misdiagnosed as\u00a0\u201ccarcinomatosis\u201d,\u00a0and in the postoperative period these\u00a0cases\u00a0were\u00a0complicated with septic shock.\u00a0In both cases, histopathology\u00a0showed\u00a0caseating granulomas\u00a0which\u00a0suggested\u00a0tuberculous\u00a0peritonitis and enteritis. Subsequently,\u00a0RT-PCR in peritoneal fluid confirmed\u00a0\n                    <ns3:italic>Mycobacterium tuberculosis<\/ns3:italic>\n                    . In one case the clinical response to treatment was excellent,\u00a0and the other case was fatal.\n                  <\/ns3:p>\n                  <ns3:p>The aim of this report is to\u00a0bring attention to\u00a0the spectrum of tuberculosis, and to serve as a reminder of tuberculosis as the great imitator that can masquerade as cancer. Most tuberculous patients erroneously diagnosed as cancer have extensive \u201cneoplastic\u201d lesions that would suggest an advanced-stage malignancy. Assuming a case as an advanced cancer would reduce the chance of performing more exhaustive studies to get a definitive diagnosis and clinicians would be tempted to offer only palliative treatments.<\/ns3:p>","DOI":"10.12688\/f1000research.53036.2","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T12:00:27Z","timestamp":1626091227000},"page":"355","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Abdominal\u00a0tuberculosis misdiagnosed as\u00a0acute surgical abdomen and carcinomatosis"],"prefix":"10.12688","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1814-5593","authenticated-orcid":false,"given":"Edinson Dante","family":"Meregildo-Rodriguez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosita Claudia","family":"Tafur-Ramirez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter Giovanny","family":"Espino-Saavedra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia Fiorella","family":"Angulo-Prentice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2021,7,12]]},"reference":[{"key":"ref2","doi-asserted-by":"publisher","first-page":"299-310","DOI":"10.17843\/rpmesp.2017.342.2384","article-title":"Tuberculosis en el Per\u00fa: situaci\u00f3n epidemiol\u00f3gica, avances y desaf\u00edos para su control.","volume":"34","author":"V Alarc\u00f3n","year":"2017","journal-title":"Rev. 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Salud Publica."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1331-1384","DOI":"10.1016\/S0140-6736(19)30024-8","article-title":"Building a tuberculosis-free world: The Lancet Commission on tuberculosis.","volume":"393","author":"M Reid","year":"2019","journal-title":"Lancet."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"14831-14840","DOI":"10.3748\/wjg.v20.i40.14831","article-title":"Abdominal tuberculosis of the gastrointestinal tract: revisited.","volume":"20","author":"U Debi","year":"2014","journal-title":"World J Gastroenterol."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"685-700","DOI":"10.1111\/j.1365-2036.2005.02645.x","article-title":"Systematic review: tuberculous peritonitis \u2014presenting features, diagnostic strategies and treatment.","volume":"22","author":"F Sanai","year":"2005","journal-title":"Aliment Pharmacol Ther."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"567-72","DOI":"10.7326\/0003-4819-76-4-567","article-title":"Tuberculous peritonitis. Prospective study of 32 cases in Iran.","volume":"76","author":"F Borhanmanesh","year":"1972","journal-title":"Ann Intern Med."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"151-3","DOI":"10.1016\/j.ijmyco.2015.02.004","article-title":"Tuberculosis peritonitis with features of acute abdomen in HIV infection.","volume":"4","author":"K Sabooni","year":"2015","journal-title":"Int J Mycobacteriol."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"77-83","DOI":"10.17843\/rpmesp.2018.351.3602","article-title":"Tuberculosis que imita c\u00e1ncer: casos derivados al Instituto Nacional de Enfermedades Neopl\u00e1sicas, Lima-Per\u00fa.","volume":"35","author":"J Villena-Suarez","year":"2018","journal-title":"Rev Peru Med Exp Salud Publica."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"822-825","DOI":"10.1016\/0002-9343(84)90993-8","article-title":"Tuberculosis mimicking cancer \u2014a reminder.","volume":"76","author":"S Pitlik","year":"1984","journal-title":"Am J Med."},{"key":"ref10","first-page":"52-59","article-title":"Tuberculosis Intestinal Simulando C\u00e1ncer de Colon: Reporte de Caso y Revisi\u00f3n.","volume":"19","author":"G Ibarra","year":"2016","journal-title":"Rev Cient Cienc M\u00e9d."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"387-391","DOI":"10.4067\/S0716-10182019000300387","article-title":"Duodenal obstruction and upper gastrointestinal bleeding as the initial presentation of an isolated duodenal tuberculosis.","volume":"36","author":"E Meregildo-Rodr\u00edguez","year":"2019","journal-title":"Rev Chilena Infectol."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"e147-e195","DOI":"10.1093\/cid\/ciw376","article-title":"Official American Thoracic Society\/Centers for Disease Control and Prevention\/Infectious Diseases Society of America Clinical Practice Guidelines: Treatment of Drug-Susceptible Tuberculosis.","volume":"63","author":"P Nahid","year":"2016","journal-title":"Clin Infect Dis."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s13017-019-0252-3","article-title":"Diagnosis of abdominal tuberculosis: lessons learned over 30 years: pectoral assay.","volume":"14","author":"F Abu-Zidan","year":"2019","journal-title":"World J Emerg Surg."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s12981-017-0139-x","article-title":"Possible misdiagnosis of HIV associated lymphoma as tuberculosis among patients attending Uganda Cancer Institute.","volume":"14","author":"K Bae","year":"2017","journal-title":"AIDS Res Ther."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"636-640","DOI":"10.4269\/ajtmh.14-0656","article-title":"The relevance of biopsy in tuberculosis patients without human immunodeficiency virus infection.","volume":"92","author":"K Bae","year":"2015","journal-title":"Am J Trop Med Hyg."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"351-6","DOI":"10.1055\/s-2005-861116","article-title":"Clinical, colonoscopic, and histological profile of colonic tuberculosis in a tertiary hospital.","volume":"37","author":"J Alvares","year":"2005","journal-title":"Endoscopy."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1186\/s12879-015-0944-6","article-title":"A systematic review of hepatic tuberculosis with considerations in human immunodeficiency virus co-infection.","volume":"15","author":"A Hickey","year":"2015","journal-title":"BMC Infect Dis."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"244-5","DOI":"10.1200\/JGO.2016.004457","article-title":"Misdiagnosis of Cancer as Tuberculosis in Low- to Middle-Income Countries: A Tip of the Iceberg!","volume":"2","author":"A Hannan","year":"2016","journal-title":"J Glob Oncol."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"e0251547","DOI":"10.1371\/journal.pone.0251547","article-title":"Strengthening health systems to improve the value of tuberculosis diagnostics in South Africa: A cost and cost-effectiveness analysis.","volume":"16","author":"N Foster","year":"2021","journal-title":"PLoS 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.56377.r85112, Uzair Yaqoob, Dow University of Health Sciences, Karachi, Pakistan, 01 Jun 2021, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/10-355\/v1#referee-response-85112","order":0,"name":"referee-response-85112","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.56377.r85111, Virgilio Efrain Failoc Rojas, Research Unit for the Generation and Synthesis of Evidence in Health, Universidad San Ignacio de Loyola, Lima, Peru, 29 Jun 2021, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/10-355\/v1#referee-response-85111","order":1,"name":"referee-response-85111","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}