{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T17:11:28Z","timestamp":1784999488139,"version":"3.55.0"},"reference-count":16,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    Mixed infections with two or more species of\n                    <ns3:italic>Plasmodium<\/ns3:italic>\n                    are frequently reported due to vector factors, parasite factors (formation of hypnozoites) and host factors (residing in endemic areas, travel to endemic areas, inadequately treated previous infection, lack of compliance to therapy). Here we report a case of a 33-year-old Saudi female who had a significant travel history, and a peripheral blood smear (PBS) revealed mixed infection with\n                    <ns3:italic>P. falciparum<\/ns3:italic>\n                    and\n                    <ns3:italic>P. vivax<\/ns3:italic>\n                    . The case was successfully treated with a combination therapy of artemisinin and primaquine with follow up testing at three, seven, 14, and 28 days.\n                  <\/ns3:p>\n                  <ns3:p>Mixed malaria infections are especially reported in travelers to endemic areas. Hence, adequate diagnosis and appropriate treatment of the cases contributes majorly to preventing relapse and controlling the disease. Travel consultations should be given to all travelers before their trips to endemic countries.<\/ns3:p>","DOI":"10.12688\/f1000research.53162.1","type":"journal-article","created":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T11:38:03Z","timestamp":1628509083000},"page":"779","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Case report: Mixed infection of Plasmodium vivax and Plasmodium falciparum in a tertiary hospital"],"prefix":"10.12688","volume":"10","author":[{"given":"Abeer M.","family":"Al-Subaie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2021,8,9]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"748-767","DOI":"10.3390\/toxins4090748","article-title":"The biological control of the malaria vector.","volume":"4","author":"L 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infections are associated with severe malaria in children: a prospective cohort study from Papua New Guinea.","volume":"5","author":"B Genton","year":"2008","journal-title":"PLoS Med."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"206-12","DOI":"10.2478\/s11686-014-0227-1","article-title":"Clinico-pathological studies of Plasmodium falciparum and Plasmodium vivax - malaria in India and Saudi Arabia.","volume":"59","author":"W Khan","year":"2014","journal-title":"Acta Parasitol."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"1332-1337","DOI":"10.3855\/jidc.13246","article-title":"Epidemiological trends of malaria in the Western regions of Saudi Arabia: a cross sectional study.","volume":"14","author":"O Amer","year":"2020","journal-title":"J Infect Dev Ctries."},{"key":"ref-8","first-page":"73-80","article-title":"Clinical Profile of Severe Plasmodium falciparum and P. vivax Malaria in Jazan Region, Saudi Arabia.","volume":"16","author":"M 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policies and practices in malaria endemic countries.","volume":"12","author":"J Recht","year":"2018","journal-title":"PLoS Negl Trop Dis."},{"key":"ref-16","doi-asserted-by":"publisher","first-page":"838-45","DOI":"10.1124\/jpet.105.086488","article-title":"Primaquine-induced hemolytic anemia: role of membrane lipid peroxidation and cytoskeletal protein alterations in the hemotoxicity of 5-hydroxyprimaquine.","volume":"314","author":"Z Bowman","year":"2005","journal-title":"J Pharmacol Exp 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.56516.r91522, Mira El Chaar, Faculty of Health Sciences, University of Balamand, Beirut, Lebanon, 01 Sep 2021, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/10-779\/v1#referee-response-91522","order":0,"name":"referee-response-91522","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.56516.r92549, Ali M. Gabali, Department of Pathology, Karmanos Cancer Center, Wayne State University School of Medicine, Detroit, MI, USA, 21 Sep 2021, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/10-779\/v1#referee-response-92549","order":1,"name":"referee-response-92549","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}