{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T15:24:32Z","timestamp":1774538672322,"version":"3.50.1"},"reference-count":11,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T00:00:00Z","timestamp":1623110400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Familial hCG syndrome is a rare and benign cause of elevated serum beta human chorionic gonadotropin (hCG). We present here a case of familial hCG syndrome diagnosed in a Hong Kong Chinese family, which we believe to be the first reported in Chinese. A 38-year-old woman presented with incidental finding of persistently elevated hCG, analytically confirmed both in urine and blood. Extensive radiological and biochemical work-up were performed but were negative for pregnancy and malignancy. Testing of another asymptomatic family member revealed unexplained elevation of serum hCG, confirming the diagnosis of familial hCG syndrome. Knowledge and awareness of this entity among clinicians are important to avoid unnecessary investigations and treatment in affected families.<\/ns3:p>","DOI":"10.12688\/f1000research.53636.1","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T11:40:17Z","timestamp":1623152417000},"page":"458","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Case Report: The first familial hCG syndrome in a Chinese family"],"prefix":"10.12688","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3570-8397","authenticated-orcid":false,"given":"Ling-Yin","family":"Hung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-Tik","family":"Leung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toby Chun-Hei","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoi-Ning","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wai-Hon","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yui-Shing","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assumpta Sze-Man","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Chung","family":"Shek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sammy Pak-Lam","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2021,6,8]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"52-7","DOI":"10.1016\/j.jri.2011.11.001","article-title":"Familial hCG Syndrome.","volume":"93","author":"L Cole","year":"2012","journal-title":"J Reprod Immunol."},{"key":"ref-2","first-page":"435-42","article-title":"Familial hcg syndrome: Production of variable, degraded or mutant forms of hcg.","volume":"59","author":"L Cole","year":"2014","journal-title":"J Reprod Med."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"47-8","DOI":"10.1016\/j.gynor.2014.05.005","article-title":"Familial HCG syndrome: A diagnostic challenge.","volume":"10","author":"A Tan","year":"2014","journal-title":"Gynecol Oncol 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