{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:10:36Z","timestamp":1772169036720,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.54233.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T00:00:00Z","timestamp":1631232000000}}],"reference-count":17,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T00:00:00Z","timestamp":1631232000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Celiac disease (CD) is an autoimmune enteropathy resulting from intolerance of an individual genetically predisposed to gluten. It has a large clinical polymorphism ranging from a classic digestive clinical presentation due to the malabsorption syndrome to extra-intestinal symptoms. Among the hematologic abnormalities, venous thromboembolic disease (VTE) has been reported, and they are most often located in the abdomen or lower limbs, but the cerebral localization was exceptionally described. We report a case of CD revealed by cerebral thrombophlebitis.<\/ns3:p>\n                  <ns3:p>A 44-year-old patient with no medical history and no drug intake, presented with hemiplegia followed by a status epilepticus\u00a0in a context of apyrexia, initially hospitalized in intensive care. Magnetic imaging resonance displayed a cerebral venous thrombosis of the sigmoid sinus requiring anticoagulant treatment, then transferred to our department for the etiological investigation. On questioning, the patient reported chronic diarrhea and weight loss with no other associated symptoms. The examination revealed an underweight patient with pale conjunctiva, improvement of her deficit symptoms, and no other abnormalities.<\/ns3:p>\n                  <ns3:p>Laboratory tests noted biological signs of malabsorption. The thrombophilia assessment revealed a protein C deficiency with a slight increase in anticardiolipin antibodies and anti-Beta 2 glycoprotein 1 antibodies. Immunological tests noted positives anti-transglutaminase and IgA anti-endomysium antibodies. Duodenal biopsy demonstrated villous atrophy. After ruling out the other causes of VTE, the diagnosis of cerebral venous thrombosis secondary to CD was retained.<\/ns3:p>\n                  <ns3:p>Early diagnosis and treatment of CD improves the quality-of-life for patients and may spare them various long-term or even fatal complications.<\/ns3:p>","DOI":"10.12688\/f1000research.54233.2","type":"journal-article","created":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T06:30:10Z","timestamp":1631255410000},"page":"680","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Cerebral venous thrombosis revealing celiac disease"],"prefix":"10.12688","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8559-0393","authenticated-orcid":false,"given":"Romdhane","family":"Wiem","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7797-4899","authenticated-orcid":false,"given":"Arfa","family":"Sondess","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chelly","family":"Jihene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3688-5264","authenticated-orcid":false,"given":"Jomaa","family":"Olfa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hammami","family":"Sonia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6960-0301","authenticated-orcid":false,"given":"Hmida","family":"Karima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El Arbi","family":"Fatma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berriche","family":"Olfa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2021,9,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"557-561","DOI":"10.3109\/07853890.2010.523229","article-title":"Are we not over-estimating the prevalence of celiac disease in the general population?","volume":"42","author":"F Biagi","year":"2010","journal-title":"Ann Med."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"412-421","DOI":"10.1182\/blood-2006-07-031104","article-title":"Hematologic manifestations of celiac disease.","volume":"109","author":"T Halfdanarson","year":"2007","journal-title":"Blood."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1240-1245","DOI":"10.1111\/jgh.13282","article-title":"Risk of venous 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histopathological features of celiac disease.","volume":"103","author":"S Vivas","year":"2008 Sep","journal-title":"Am J Gastroenterol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"478-483","DOI":"10.1097\/MPG.0000000000001420","article-title":"Extraintestinal Manifestations Associated with Celiac Disease.","volume":"24","author":"Y Kayar","year":"2019","journal-title":"East J Med."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"3415-3422","DOI":"10.1182\/blood-2013-05-427708","article-title":"Inflammation, obesity, and thrombosis.","volume":"122","author":"F Samad","year":"2013","journal-title":"Blood."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"120-138","DOI":"10.2450\/2010.0066-10","article-title":"Risk factors for venous and arterial thrombosis.","volume":"9","author":"E Previtali","year":"2011","journal-title":"Blood 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Kurppa","year":"2014","journal-title":"Gastroenterology."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"567-575","DOI":"10.1177\/2050640617751253","article-title":"Delayed celiac disease diagnosis predisposes to reduced quality of life and incremental use of health care services and medicines: A prospective nationwide study.","volume":"6","author":"K Kurppa","year":"2018 May","journal-title":"United European Gastroenterol 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.77205.r94004, Juha Taavela, Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland, 13 Sep 2021, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/10-680\/v2#referee-response-94004","order":0,"name":"referee-response-94004","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.77205.r94003, Bouomrani Salem, Department of Internal Medicine, Military Hospital of Gabes, Gabes, Tunisia, 16 Sep 2021, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/10-680\/v2#referee-response-94003","order":1,"name":"referee-response-94003","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this 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