{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:10:33Z","timestamp":1772169033107,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.54569.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000}}],"reference-count":5,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:00:00Z","timestamp":1646265600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"none"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>We present a case of a 36-year-old\u00a0female patient who presented with subacute liver disease with a history of alcohol abuse. On basic liver function tests (LFT), she had\u00a0aspartate transaminase\u00a0\/ alanine transaminase &gt; 2.2 and alkaline phosphatase \/ total bilirubin &lt; 4. This pattern in acute liver failure patients signifies Wilson\u2019s disease. Its presence in our patient with subacute liver disease also prompted us to suspect Wilson\u2019s disease and we extended the liver disease screen to include slit lamp eye examination for Kayser-Fleischer rings, serum ceruloplasmin and\u00a024-hour\u00a0urinary copper level,\u00a0which led to the diagnosis. She improved clinically and biochemically with zinc acetate therapy. \u00a0As screening for rare diseases is not always possible in low-income countries, this case demonstrates the usefulness of the basic LFT as a guide for suspecting Wilson\u2019s disease in patients with liver disease.<\/ns3:p>","DOI":"10.12688\/f1000research.54569.2","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T11:30:21Z","timestamp":1646307021000},"page":"608","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Using basic liver function tests\u00a0as a guide\u00a0to suspected\u00a0Wilson\u2019s disease"],"prefix":"10.12688","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2659-3425","authenticated-orcid":false,"given":"Sudeep","family":"Adhikari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3953-1533","authenticated-orcid":false,"given":"Prashant Kumar","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuba Raj","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2022,3,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"321-36","DOI":"10.1016\/j.jceh.2013.06.002","article-title":"A review and current perspective on Wilson disease.","volume":"3","author":"M Patil","year":"2013 Dec 1","journal-title":"J Clin Exp Hepatol."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.16175.2","article-title":"Case Report: Pulmonary tuberculosis and raised transaminases without pre-existing liver disease-Do we need to modify the antitubercular therapy?","volume":"5","author":"S Gautam","year":"2020","journal-title":"Wellcome Open Res."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"183","DOI":"10.2147\/CEG.S81321","article-title":"Alcoholic liver disease in Nepal: identifying homemade alcohol as a culprit.","volume":"8","author":"B Pradhan","year":"2015","journal-title":"Clin Exp Gastroenterol."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1167-74","DOI":"10.1002\/hep.22446","article-title":"Screening for Wilson disease in acute liver failure: a comparison of currently available diagnostic tests.","volume":"48","author":"J Korman","year":"2008 Oct","journal-title":"Hepatology."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"671-85","DOI":"10.1016\/j.jhep.2011.11.007","article-title":"EASL clinical practice guidelines: Wilson\u2019s disease.","volume":"56","year":"2012 Mar 1","journal-title":"J Hepatol."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/10-608\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/10-608\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/10-608\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T06:45:12Z","timestamp":1649918712000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/10-608\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,3]]},"references-count":5,"URL":"https:\/\/doi.org\/10.12688\/f1000research.54569.2","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.120012.r126145","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.120012.r126145","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,3]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/10-608\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.120012.r126145, Raffaele Iorio, Department of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, Naples, Italy, 14 Apr 2022, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/10-608\/v2#referee-response-126145","order":0,"name":"referee-response-126145","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.58069.r100231, Jason L. Burkhead, Department of Biological Sciences, University of Alaska Anchorage, Anchorage, AK, USA, 09 Dec 2021, version 1, 1 approved, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/10-608\/v1#referee-response-100231","order":1,"name":"referee-response-100231","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Sudeep Adhikari<\/b>; \n<i>Posted: 14 Jan 2022<\/i>; Thank you for the review, and the constructive feedback.","URL":"https:\/\/f1000research.com\/articles\/10-608\/v2#referee-comment-7704","order":2,"name":"referee-comment-7704","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}