{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:10:03Z","timestamp":1772169003289,"version":"3.50.1"},"reference-count":17,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:00:00Z","timestamp":1627862400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Sarcomatoid carcinoma of the lung is an uncommon subtype of non-small-cell lung cancer (NSCLC). Even in the early stages, pulmonary sarcomatoid carcinoma (PSC) has a dismal prognosis when compared to other kinds of NSCLC with a mean survival of 9\u201312 months and a five-year survival rate of around 20%. We present the case of a 68-year-old woman with a two-month history of shortness of breath and cough. Initial computed tomography (CT) scan showed features of interstitial lung disease with chronic obstructive airway changes. After 34 months, the patient\u2019s condition worsened with newer complaints of sore throat and hemoptysis. A repeat CT scan showed a \u223c49x38x59mm size lesion in the superior segment of the left lower lobe. A core needle biopsy was performed, which revealed tumor cells consisting of irregular tubules and sarcomatoid components. The patient was started on chemotherapy. Unfortunately, she succumbed to her disease. Our case highlights the aggressiveness of PSC.<\/ns3:p>","DOI":"10.12688\/f1000research.55187.1","type":"journal-article","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T12:01:58Z","timestamp":1627905718000},"page":"723","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Pulmonary sarcomatoid carcinoma in a female patient from Nepal"],"prefix":"10.12688","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6010-4640","authenticated-orcid":false,"given":"Anirudra","family":"Devkota","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amrit","family":"Paudel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simit","family":"Sapkota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subash","family":"Pandit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aashish","family":"Baniya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2021,8,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"115-120","DOI":"10.1016\/j.tranon.2016.11.009","article-title":"Pulmonary Sarcomatoid Carcinoma with ALK Rearrangement: Frequency, Clinical-Pathologic Characteristics, and Response to ALK Inhibitor.","volume":"10","author":"X Chen","year":"2017","journal-title":"Transl Oncol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"753-756","DOI":"10.1590\/S1806-37132013000600016","article-title":"Sarcomatoid carcinoma of the lung with brain metastases Carcinoma sarcomatoide de pulm\u00e3o com met\u00e1stases cerebrais.","volume":"39","author":"M Fernandes De Oliveira","year":"2013","journal-title":"J Bras Pneumol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2936-2945","DOI":"10.1002\/1097-0142(19940615)73:12<2936::aid-cncr2820731210=3.0.co;2-u","article-title":"Pleomorphic (spindle\/giant cell) carcinoma of the lung. A clinicopathologic correlation of 78 cases.","volume":"73","author":"N Fishback","year":"1994","journal-title":"Cancer."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"49-54","DOI":"10.5858\/2008-0547-RAR.1","article-title":"Sarcomatoid Carcinoma of the Lung: Histologic Criteria and Common Lesions in the Differential Diagnosis.","volume":"134","author":"T Franks","year":"2010","journal-title":"Arch Pathol Lab Med."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"844-852","DOI":"10.1016\/s0022-5223(19)36826-6","article-title":"Carcinosarcoma and spindle cell carcinoma of the lung.","volume":"100","author":"T Ishida","year":"1990","journal-title":"J Thorac Cardiovasc Surg."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e44","DOI":"10.4081\/rt.2010.e44","article-title":"Predominant sarcomatoid carcinoma of the lung concurrent with jejunal metastasis and leukocytosis.","volume":"2","author":"J Jia","year":"2010","journal-title":"Rare Tumors."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"78-82","DOI":"10.3904\/kjim.2002.17.1.78","article-title":"A case of pulmonary carcinosarcoma with persistent mild fever.","volume":"17","author":"H Kim","year":"2002","journal-title":"Korean J Intern Med."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1758835920950207","DOI":"10.1177\/1758835920950207","article-title":"Pulmonary sarcomatoid carcinoma: progress, treatment and expectations.","volume":"12","author":"X Li","year":"2020","journal-title":"Ther Adv Med Oncol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"e323-e333","DOI":"10.1016\/j.cllc.2017.12.008","article-title":"Sarcomatoid Carcinoma of the Lung: The Mayo Clinic Experience in 127 Patients.","volume":"19","author":"K Maneenil","year":"2018","journal-title":"Clin Lung Cancer."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"342-345","DOI":"10.4103\/1947-2714.136920","article-title":"Sarcomatoid carcinoma of the lung: A model of resistance of chemotherapy.","volume":"6","author":"I Ouziane","year":"2014","journal-title":"N Am J Med Sci."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"734-737","DOI":"10.1902\/jop.2006.050137","article-title":"Initial Presentation of Lung Sarcomatoid Carcinoma as a Metastatic Lesion in the Mandibular Gingiva.","volume":"77","author":"J Park","year":"2006","journal-title":"J Periodontol."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"103-120","DOI":"10.1177\/1066896908330049","article-title":"Pulmonary sarcomatoid carcinomas: A practical overview.","volume":"18","author":"G Pelosi","year":"2010","journal-title":"Int J Surg Pathol."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"143-146","DOI":"10.1016\/j.rmcr.2018.05.016","article-title":"Sarcomatoid Carcinoma of Lung Presenting as Localized Bronchiectasis: A Case Report and Review of Literature.","volume":"24","author":"K Rajdev","year":"2018","journal-title":"Respir Med Case 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programmed death ligand-1 (PD-L1).","volume":"8","author":"V Velcheti","year":"2013","journal-title":"J Thorac 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.58744.r91016, Alina Basnet, Department of Hematology\/Oncology, SUNY Upstate Medical University, Syracuse, NY, USA, 27 Aug 2021, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/10-723\/v1#referee-response-91016","order":0,"name":"referee-response-91016","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Anirudra Devkota<\/b>; \n<i>Posted: 02 Sep 2021<\/i>; Radiotherapy was planned but couldn't be performed as the patient rapidly deteriorated. Low dose chemotherapy was preferred because our patient was elderly, and also the general condition was poor. We couldn't perform the Bone scan and PET Scan as it was not available in our hospital. Diagnostic centers were also closed due to COVID lockdown. CT chest together with upper abdomen was done, but CT abdomen separately was not performed.","URL":"https:\/\/f1000research.com\/articles\/10-723\/v1#referee-comment-7117","order":1,"name":"referee-comment-7117","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.58744.r93529, Jian-Hong Fang, Yun Zhou, MOE Key Laboratory of Gene Function and Regulation, School of Life Sciences, Sun Yat-sen University, Guangzhou, China, 15 Sep 2021, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/10-723\/v1#referee-response-93529","order":2,"name":"referee-response-93529","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.58744.r118657, Ramila Shilpakar, Bir Hospital, National Academy of Medical Sciences, Kathmandu, Nepal, 14 Mar 2022, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/10-723\/v1#referee-response-118657","order":3,"name":"referee-response-118657","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}