{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:23:49Z","timestamp":1790706229287,"version":"4.1.0"},"update-to":[{"DOI":"10.12688\/f1000research.55221.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000}}],"reference-count":33,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    <ns3:bold>Background:<\/ns3:bold>\n                    Vitamin D deficiency is seen more frequently in diabetic patients with distal symmetrical polyneuropathy. Unfortunately, there is a shortage of data concerning prediabetic individuals with peripheral neuropathy (PN). Therefore, we aimed to study the association of vitamin D deficiency with PN severity and to determine the effect of vitamin D supplementation on PN in prediabetics.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Methods:<\/ns3:bold>\n                    A case-control study was conducted consisting of 89 prediabetic individuals with PN and a control group of prediabetics without PN, recruited from the outpatient department of the National Institute of Diabetes and Endocrinology, Cairo, Egypt. All patients were screened for PN using clinical examination and Douleur Neuropathique 4 diagnostic questionnaire (DN4). Group A (with PN) was assessed for neuropathic severity using the Short-Form McGill Pain Questionnaire (SF-MPQ). In addition, 25-hydroxyvitamin D, ionized calcium, phosphorus, parathyroid hormone (PTH), glycated hemoglobin (HbA1c), fasting blood glucose (FBG), 2-hour post 75g glucose (2h-PPBG) and lipid profile were measured for both groups. Prediabetic patients with PN were given vitamin D3 200.000 IU IM monthly for three months. After three months, clinical assessment, DN4, SF-MPQ and all laboratory measures were repeated.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Results:<\/ns3:bold>\n                    Vitamin D was not associated with the severity of PN patients. However, supplementation of vitamin D resulted in a highly significant improvement in glycemic parameters , p\u22640.001. Interestingly, neuropathy score and severity before vitamin D supplementation were (6.4\u00b11.6 and 28.3\u00b17.2) and after became (2.5\u00b10.9 and 17\u00b16.3, p\u22640.001).\n                    <ns3:bold\/>\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Conclusion:<\/ns3:bold>\n                    Correction of vitamin D deficiency in prediabetics with PN as well as hypovitaminosis D, improves glycemic parameters, PN score and severity.\n                  <\/ns3:p>","DOI":"10.12688\/f1000research.55221.2","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T07:35:07Z","timestamp":1635752107000},"page":"817","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["The impact of vitamin D supplementation on peripheral neuropathy in a sample of Egyptian prediabetic individuals"],"prefix":"10.12688","volume":"10","author":[{"given":"Mohamed","family":"Reda Halawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman","family":"Zaky Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahla","family":"Fawzy Abouelezz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagwa","family":"Roushdy Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8506-8826","authenticated-orcid":false,"given":"Naira","family":"Hany Abdelaziz Khalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila","family":"Mahmoud Ali Hendawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2021,11,1]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"25-31","DOI":"10.1016\/j.jcte.2017.04.001","article-title":"The association between vitamin D level and diabetic peripheral neuropathy in patients with type 2 diabetes mellitus: An update systematic review and meta-analysis.","volume":"9","author":"G Qu","year":"2017","journal-title":"J Clin Transl Endocrinol."},{"key":"ref-2","article-title":"IDF diabetes atlas 9th edition","year":"2019"},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"810-816","DOI":"10.1111\/j.1468-1331.2008.02197.x","article-title":"Idiopathic polyneuropathy and impaired glucose metabolism in a Norwegian patient series.","volume":"15","author":"M Nebuchennykh","year":"2008","journal-title":"Eur J Neurol."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"266-281","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency.","volume":"357","author":"M Holick","year":"2007","journal-title":"N Engl J Med."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"642","DOI":"10.3390\/nu11030642","article-title":"Vitamin D Status, Calcium Intake and Risk of Developing Type 2 Diabetes: An Unresolved Issue.","volume":"11","author":"A Mu\u00f1oz-Garach","year":"2019","journal-title":"Nutrients."},{"key":"ref-6","first-page":"1-17","article-title":"Criteria for testing for diabetes or prediabetes in asymptomatic adults.","volume":"42","year":"2019","journal-title":"American Diabetes Association."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"29-36","DOI":"10.1016\/j.pain.2004.12.010","article-title":"Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4).","volume":"114","author":"D Bouhassira","year":"2005","journal-title":"Pain."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"S240-52","DOI":"10.1002\/acr.20543","article-title":"Measures of adult pain: Visual Analog Scale for Pain (VAS Pain), Numeric Rating Scale for Pain (NRS Pain), McGill Pain Questionnaire (MPQ), Short-Form McGill Pain Questionnaire (SF-MPQ), Chronic Pain Grade Scale (CPGS), Short Form-36 Bodily Pain Scale (SF-36 BPS), and Measure of Intermittent and Constant Osteoarthritis Pain (ICOAP).","volume":"63 Suppl 11","author":"G Hawker","year":"2011","journal-title":"Arthritis Care Res (Hoboken)."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"149-55","DOI":"10.3329\/jhpn.v29i2.7857","article-title":"Prevalence of vitamin D deficiency among adult population of Isfahan City, Iran.","volume":"29","author":"S Hovsepian","year":"2011","journal-title":"J Health Popul Nutr."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"12-15","DOI":"10.18773\/austprescr.2015.004","article-title":"Measuring vitamin D.","volume":"38","author":"P Glendenning","year":"2015","journal-title":"Aust Prescr."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s41983-019-0058-y","article-title":"Diabetic peripheral neuropathy: the potential role of vitamin D deficiency.","volume":"55","author":"M Oraby","year":"2019","journal-title":"Egypt J Neurol Psychiatr Neurosurg."},{"key":"ref-12","doi-asserted-by":"publisher","first-page":"135-151","DOI":"10.2337\/dc20-S011","article-title":"11. Microvascular complications and foot care: Standards of Medical Care in Diabetes-2020.","volume":"43","year":"2020","journal-title":"Diabetes Care."},{"key":"ref-13","doi-asserted-by":"publisher","first-page":"387-92","DOI":"10.4103\/2230-8210.152783","article-title":"Effect of vitamin D supplementation on glycemic parameters and progression of prediabetes to diabetes: a 1-year, open-label randomized study.","volume":"19","author":"M Kuchay","year":"2015","journal-title":"Indian J Endocrinol Metab."},{"key":"ref-14","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/s13098-016-0188-7","article-title":"Relationship between vitamin D status, glycemic control and cardiovascular risk factors in Brazilians with type 2 diabetes mellitus.","volume":"8","author":"M Rolim","year":"2016","journal-title":"Diabetol Metab Syndr."},{"key":"ref-15","doi-asserted-by":"publisher","first-page":"194-9","DOI":"10.1177\/1479164109337974","article-title":"Hypovitaminosis D in Chinese type 2 diabetes: lack of impact on clinical metabolic status and biomarkers of cellular inflammation.","volume":"6","author":"C Luo","year":"2009","journal-title":"Diab Vasc Dis Res."},{"key":"ref-16","doi-asserted-by":"publisher","first-page":"185-197","DOI":"10.1111\/j.1463-1326.2007.00710.x","article-title":"Role of vitamin D in the pathogenesis of type 2 diabetes mellitus.","volume":"10","author":"X Palomer","year":"2008","journal-title":"Diabetes Obes Metab."},{"key":"ref-17","doi-asserted-by":"publisher","first-page":"351385","DOI":"10.1155\/2010\/351385","article-title":"Role of vitamin D in insulin secretion and insulin sensitivity for glucose homeostasis.","volume":"2010","author":"J Alvarez","year":"2010","journal-title":"Int J Endocrinol."},{"key":"ref-18","doi-asserted-by":"publisher","first-page":"43-49","DOI":"10.1111\/j.1464-5491.2011.03510.x","article-title":"Does Vitamin D deficiency play a role in peripheral neuropathy in Type 2 diabetes?","volume":"29","author":"D Shehab","year":"2012","journal-title":"Diabet Med."},{"key":"ref-19","doi-asserted-by":"publisher","first-page":"44-51","DOI":"10.1111\/dme.13798","article-title":"Reduced vitamin D levels in painful diabetic peripheral neuropathy.","volume":"36","author":"P Shillo","year":"2019","journal-title":"Diabet Med."},{"key":"ref-20","doi-asserted-by":"publisher","first-page":"e000148","DOI":"10.1136\/bmjdrc-2015-000148","article-title":"Vitamin D for the treatment of painful diabetic neuropathy.","volume":"4","author":"A Basit","year":"2016","journal-title":"BMJ Open Diabetes Res Care."},{"key":"ref-21","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s12902-015-0029-y","article-title":"The relationship between microvascular complications and vitamin D deficiency in type 2 diabetes mellitus.","volume":"15","author":"C Usluogullari","year":"2015","journal-title":"BMC Endocr Disord."},{"key":"ref-22","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2820","article-title":"Vitamin D deficiency increases the risk of peripheral neuropathy in Chinese patients with type 2 diabetes.","volume":"33","author":"R He","year":"2017","journal-title":"Diabetes Metab Res Rev."},{"key":"ref-23","doi-asserted-by":"publisher","first-page":"e000690","DOI":"10.1136\/bmjdrc-2019-000690","article-title":"Neuropathic pain is not associated with serum vitamin D but is associated with female gender in patients with type 2 diabetes mellitus.","volume":"7","author":"M Alkhatatbeh","year":"2019","journal-title":"BMJ Open Diabetes Res Care."},{"key":"ref-24","doi-asserted-by":"publisher","first-page":"319-27","DOI":"10.5603\/ep.2013.0012","article-title":"Practical guidelines for the supplementation of vitamin D and the treatment of deficits in Central Europe - recommended vitamin D intakes in the general population and groups at risk of vitamin D deficiency.","volume":"64","author":"P P\u0142udowski","year":"2013","journal-title":"Endokrynol Pol."},{"key":"ref-25","doi-asserted-by":"publisher","first-page":"165056","DOI":"10.1155\/2012\/165056","article-title":"Reversal of the symptoms of diabetic neuropathy through correction of vitamin D deficiency in a type 1 diabetic patient.","volume":"2012","author":"D Bell","year":"2012","journal-title":"Case Rep Endocrinol."},{"key":"ref-26","doi-asserted-by":"publisher","first-page":"250-256","DOI":"10.1159\/000375304","article-title":"Prospective evaluation of the effect of short-term oral vitamin d supplementation on peripheral neuropathy in type 2 diabetes mellitus.","volume":"24","author":"D Shehab","year":"2015","journal-title":"Med Princ Pract."},{"key":"ref-27","doi-asserted-by":"publisher","first-page":"771-772","DOI":"10.1001\/archinte.168.7.771","article-title":"Vitamin D as an analgesic for patients with type 2 diabetes and neuropathic pain.","volume":"168","author":"P Lee","year":"2008","journal-title":"Arch Intern Med."},{"key":"ref-28","doi-asserted-by":"publisher","first-page":"226-33","DOI":"10.1159\/000056351","article-title":"Tacalcitol, an active vitamin D3, induces nerve growth factor production in human epidermal keratinocytes.","volume":"14","author":"M Fukuoka","year":"2001","journal-title":"Skin Pharmacol Appl Skin Physiol."},{"key":"ref-29","doi-asserted-by":"publisher","first-page":"1308-1313","DOI":"10.1007\/s001250051443","article-title":"A vitamin D(3) derivative (CB1093) induces nerve growth factor and prevents neurotrophic deficits in streptozotocin-diabetic rats.","volume":"42","author":"S Riaz","year":"1999","journal-title":"Diabetologia."},{"key":"ref-30","doi-asserted-by":"publisher","first-page":"11-26","DOI":"10.1007\/s13300-016-0159-x","article-title":"Vitamin D and diabetic complications: true or false prophet?","volume":"7","author":"U Alam","year":"2016","journal-title":"Diabetes Ther."},{"key":"ref-31","doi-asserted-by":"publisher","first-page":"475-84","DOI":"10.3892\/br.2018.1074","article-title":"Effect of vitamin D supplementation on fasting plasma glucose, insulin resistance and prevention of type 2 diabetes mellitus in non-diabetics: A systematic review and meta-analysis.","volume":"8","author":"S He","year":"2018","journal-title":"Biomed Rep."},{"key":"ref-32","doi-asserted-by":"publisher","first-page":"133-41","DOI":"10.1111\/dom.12794","article-title":"Effect of vitamin D supplementation on oral glucose tolerance in individuals with low vitamin D status and increased risk for developing type 2 diabetes (EVIDENCE): A double-blind, randomized, placebo-controlled clinical trial.","volume":"19","author":"T Moreira-Lucas","year":"2017","journal-title":"Diabetes Obes Metab."},{"key":"ref-33","article-title":"The impact of vitamin D supplementation on peripheral neuropathy in a sample of Egyptian prediabetic individuals.","author":"M Halawa","year":"2021","journal-title":"Figshare."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/10-817\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/10-817\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/10-817\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T06:55:54Z","timestamp":1644908154000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/10-817\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,1]]},"references-count":33,"URL":"https:\/\/doi.org\/10.12688\/f1000research.55221.2","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.78627.r101602","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.78627.r121333","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.78627.r101602","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.78627.r121333","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,1]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/10-817\/v2#article-reports","order":0,"name":"referee-status","label":"Referee 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El Sagheer, Department of Internal Medicine, Faculty of Medicine, Minia University, Minia, Egypt, 15 Feb 2022, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/10-817\/v2#referee-response-121333","order":1,"name":"referee-response-121333","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}