{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:10:38Z","timestamp":1772169038006,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.5889.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T00:00:00Z","timestamp":1424736000000}},{"DOI":"10.12688\/f1000research.5889.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T00:00:00Z","timestamp":1424736000000}}],"reference-count":11,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T00:00:00Z","timestamp":1424736000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Skeletal dysplasias are disorders associated with a generalized abnormality in the skeleton. The Gollop-Wolfgang complex (GWC) is a limb deficiency disorder and an unusual limb malformation with highly variable manifestations. Here we report an interesting case of a 5-month old male baby from India with Gollop-Wolfgang Complex showing bifurcation of the right femur, ectrodactyly of both feet, ectrodactyly of left hand, syndactyly of right hand and unusual presentation of bilateral fibular agenesis and caudal (Sacrococcygeal) agenesis. The etiology of GWC in this 5 month old male baby could possibly be attributed to spontaneous gene mutation. The clinical, radiographic findings and the unusual presentation are presented in detail.<\/ns4:p>","DOI":"10.12688\/f1000research.5889.3","type":"journal-article","created":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T05:44:53Z","timestamp":1424756693000},"page":"315","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Gollop-Wolfgang Complex in a 5 month old baby"],"prefix":"10.12688","volume":"3","author":[{"given":"Ihtesham A.","family":"Qureshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohit Kumar","family":"Gudepu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravikanth","family":"Chava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sravya","family":"Emmani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed Husain","family":"Asghar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohtashim A.","family":"Qureshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nimmathota","family":"Arlappa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2015,2,24]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"327-341","DOI":"10.1097\/GIM.0b013e3181daae9b","article-title":"The skeletal dysplasias.","volume":"12","author":"D Krakow","year":"2010","journal-title":"Genet Med."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"409-413","DOI":"10.1097\/BPB.0b013e3282f057f3","article-title":"A 5-year follow-up study after knee disarticulation in two cases of Gollop-Wolfgang complex.","volume":"16","author":"C Bos","year":"2007","journal-title":"J Pediatr Orthop B."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"479-81","DOI":"10.1002\/(SICI)1096-8628(19960614)63:3<479::AID-AJMG12>3.0.CO;2-J","article-title":"Ectodermal dysplasia, Rapp-Hodgkin type in a mother and severe ectrodactyly-ectodermal dysplasia-clefting syndrome (EEC) in her child.","volume":"63","author":"P Moerman","year":"1996","journal-title":"Am J Med Genet."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"315-317","DOI":"10.1002\/ajmg.a.30636","article-title":"Agenesis of tibia with bifid femur, congenital heart disease, and cleft lip with cleft palate or tracheoesophageal fistula: possible variants of Gollop-Wolfgang complex.","volume":"134","author":"R Erickson","year":"2005","journal-title":"Am J Med Genet A."},{"key":"ref-5","doi-asserted-by":"crossref","first-page":"453-458","DOI":"10.2106\/00004623-198466030-00021","article-title":"Complex congenital anomalies of the lower extremities: femoral bifurcation, tibial hemimelia and diastasis of the ankle. Case report and review of the literature.","volume":"66","author":"G Wolfgang","year":"1984","journal-title":"J Bone Joint Surg."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"191-194","DOI":"10.1002\/ajmg.1320250623","article-title":"Gollop-Wolfgang Complex in a 3-month-old girl.","volume":"25","author":"I Lurie","year":"1986","journal-title":"Am J Med Genetic."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"529-530","DOI":"10.1002\/(SICI)1096-8628(19981228)80:5<529::AID-AJMG19>3.0.CO;2-9","article-title":"Bilateral involvement of hands and legs in the Gollop-Wolfgang complex.","volume":"80","author":"A Endo","year":"1998","journal-title":"Am J Med Genet."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"172-175","DOI":"10.1002\/ajmg.1320330206","article-title":"Aplasia of the tibia with bifurcation of the femur and ectrodactyly: evidence for an autosomal recessive type.","volume":"33","author":"G Kohn","year":"1989","journal-title":"Am J Med Genetics."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"361-364","DOI":"10.1002\/(SICI)1096-8628(19990604)84:4<361::AID-AJMG10>3.0.CO;2-O","article-title":"Agenesis of tibia with ectrodactyly\/Gollop-Wolfgang complex associated with congenital heart malformations and additional skeletal abnormalities.","volume":"84","author":"A Raas-Rothschild","year":"1999","journal-title":"Am J Med Genet."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"210-211","DOI":"10.1007\/s12098-009-0228-5","article-title":"Distal femoral duplication and fibular agenesis associated with congenital cardiac defect.","volume":"77","author":"M Cakir","year":"2010","journal-title":"Indian J Pediatr."},{"key":"ref-12","doi-asserted-by":"publisher","first-page":"457-463","DOI":"10.1097\/BPB.0b013e3283620640","article-title":"Limb salvage treatment for Gollop-Wolfgang complex (femoral bifurcation, complete tibial hemimelia, and hand ectrodactyly).","volume":"22","author":"A Wada","year":"2013","journal-title":"J Pediatr Orthop B."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/3-315\/v3\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/3-315\/v3\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/3-315\/v3\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T08:05:25Z","timestamp":1543997125000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/3-315\/v3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,24]]},"references-count":11,"URL":"https:\/\/doi.org\/10.12688\/f1000research.5889.3","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.6622.r8149","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.6622.r8336","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.6622.r8336","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.6622.r8149","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,24]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/3-315\/v3#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.6291.r7449, Stephen Robertson, Department of Genetics, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand, 27 Jan 2015, version 1, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/3-315\/v1#referee-response-7449","order":0,"name":"referee-response-7449","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>aatif qureshi<\/b>; \n<i>Posted: 02 Feb 2015<\/i>; Really appreciate your comments Dr. Stephen Robertson. I would like to hear back about my newer version of the paper.","URL":"https:\/\/f1000research.com\/articles\/3-315\/v3#referee-comment-1204","order":1,"name":"referee-comment-1204","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.6622.r8149, Nicole Philip, D\u00e9partement de G\u00e9n\u00e9tique M\u00e9dicale et de Biologie Cellulaire, Assistance Publique - Hopitaux de Marseille, Marseille, France, 30 Mar 2015, version 3, indexed","URL":"https:\/\/f1000research.com\/articles\/3-315\/v3#referee-response-8149","order":2,"name":"referee-response-8149","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.6622.r8336, Murat Bastepe, Qing He, Endocrine Unit, Massachusetts General Hospital, Boston, MA, 02114, USA, 19 May 2015, version 3, indexed","URL":"https:\/\/f1000research.com\/articles\/3-315\/v3#referee-response-8336","order":3,"name":"referee-response-8336","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Data associated with the article are available under the terms of the Creative Commons Zero \"No rights reserved\" data waiver (CC0 1.0 Public domain dedication).","order":0,"name":"copyright-info","label":"Copyright"}]}}