{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:10:05Z","timestamp":1772169005327,"version":"3.50.1"},"reference-count":12,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T00:00:00Z","timestamp":1424908800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    Oral appliance (OA) therapy with a mandibular advancement device (OAm) is a non-invasive, alternative approach to maintaining upper airway patency. The main requirement for an OAm to be effective is the adequate retention on the teeth while the patient is asleep. We evaluated the retentive forces of a new low-cost, customizable, titratable, thermoplastic OAm (BluePro\n                    <ns4:sup>\u00ae<\/ns4:sup>\n                    ; BlueSom, France). Dental impressions and casts were made for one patient with complete upper and lower dental arches including the third molars and class II bite proportions. A setup based on Frasaco ANA-4 models was also used. Two protrusive positions of the mandible were investigated: 3 mm and 8 mm, representing respectively 25% and 65% of the maximal protrusion. The forces required to remove the BluePro\n                    <ns4:sup>\u00ae<\/ns4:sup>\n                    device from the carriers were recorded continuously over 730 cycles (=365 days, twice a day) to simulate 1 year of clinical use. At 8 mm protrusion the BluePro\n                    <ns4:sup>\u00ae<\/ns4:sup>\n                    device showed retentive forces of ~27N. There was a slight but non-significant decrease in retentive forces in the tests on the epoxified carriers which was not found on the ANA-4 carriers. There were no significant differences between the carriers as a function of protrusion. The BluePro\n                    <ns4:sup>\u00ae<\/ns4:sup>\n                    device tested in the present study possesses sufficient retention forces to resist initial jaw opening forces and full mouth opening forces estimated to be ~20N. It could therefore broaden the indications for use of thermoplastic OAms. It could provide a temporary OAm while a custom-made OAm is being manufactured or repaired. Patients could be provided with a low-cost try-out device capable of reliable titration, providing an indication of effectiveness and of patient acceptance of an OAm, although the effect of device shape and size on therapeutic outcome is not yet known. Finally it could provide an affordable OAm solution in resource-restricted healthcare settings.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.6061.1","type":"journal-article","created":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T10:50:01Z","timestamp":1424947801000},"page":"56","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["In vitro retention of a new thermoplastic titratable mandibular advancement device"],"prefix":"10.12688","volume":"4","author":[{"given":"Marc","family":"Braem","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2015,2,26]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"177-85","DOI":"10.1016\/j.smrv.2011.06.002","article-title":"Current opinions and clinical practice in the titration of oral appliances in the treatment of sleep-disordered breathing.","volume":"16","author":"M Dieltjens","year":"2012","journal-title":"Sleep Med Rev."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"447-8","DOI":"10.5664\/JCSM.1302","article-title":"Complexity and efficacy of mandibular advancement splints: understanding their mode of action.","volume":"7","author":"F de Almeida","year":"2011","journal-title":"J Clin Sleep Med."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"439-45","DOI":"10.5664\/JCSM.1300","article-title":"Comparison of adjustable and fixed oral appliances for the treatment of obstructive sleep apnea.","volume":"7","author":"C Lettieri","year":"2011","journal-title":"J Clin Sleep Med."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"197-202","DOI":"10.1164\/rccm.200701-114OC","article-title":"Comparison of a custom-made and a thermoplastic oral appliance for the treatment of mild sleep apnea.","volume":"178","author":"O Vanderveken","year":"2008","journal-title":"Am J Respir Crit Care Med."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"1-22","DOI":"10.1007\/s11325-006-0084-8","article-title":"Review of oral appliances for treatment of sleep-disordered breathing.","volume":"11","author":"V Hoffstein","year":"2007","journal-title":"Sleep Breath."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"227-32","DOI":"10.1007\/s11325-009-0304-0","article-title":"Side effects of boil and bite type oral appliance therapy in sleep apnea patients.","volume":"14","author":"H Tsuda","year":"2010","journal-title":"Sleep Breath."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"379-86","DOI":"10.1177\/0194599812439683","article-title":"Compliance and efficacy of titratable thermoplastic versus custom mandibular advancement devices.","volume":"147","author":"M Friedman","year":"2012","journal-title":"Otolaryngol Head Neck Surg."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"313-8","DOI":"10.1007\/s11325-013-0886-4","article-title":"Retention of mandibular advancement devices in the treatment of obstructive sleep apnea: an in vitro pilot study.","volume":"18","author":"O Vanderveken","year":"2014","journal-title":"Sleep Breath."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"591-6","DOI":"10.1097\/MCP.0b013e3283319b12","article-title":"Oral appliance treatment of obstructive sleep apnea: an update.","volume":"15","author":"A Chan","year":"2009","journal-title":"Curr Opin Pulm Med."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"151-60","DOI":"10.1046\/j.1365-2842.2002.00843.x","article-title":"Forces resisting jaw displacement in relaxed humans: a predominantly viscous phenomenon.","volume":"29","author":"C Peck","year":"2002","journal-title":"J Oral Rehabil."},{"key":"ref-11","doi-asserted-by":"publisher","DOI":"10.5256\/f1000research.6061.d43120","article-title":"Dataset 1 in \u201cIn vitro retention of a new thermoplastic titratable mandibular advancement device\u201d","author":"I Spray","year":"2015","journal-title":"F1000Research."},{"key":"ref-12","doi-asserted-by":"publisher","DOI":"10.6084\/m9.figshare.1306562","article-title":"Data of retentive forces of mandibular advancement device BluePro\u00ae.","author":"I Spray","year":"2014","journal-title":"Figshare."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/4-56\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/4-56\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/4-56\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T14:50:38Z","timestamp":1543935038000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/4-56\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,26]]},"references-count":12,"URL":"https:\/\/doi.org\/10.12688\/f1000research.6061.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.6489.r7832","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.6489.r7860","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.6489.r7832","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.6489.r7860","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,26]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/4-56\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.6489.r7860, Timothy Quinnell, Respiratory Support and Sleep Centre, Papworth Hospital NHS Foundation Trust, Papworth Everard, UK, 05 Mar 2015, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/4-56\/v1#referee-response-7860","order":0,"name":"referee-response-7860","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.6489.r7832, Julia Cohen-Levy, Private Practice, Paris, France, 30 Mar 2015, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/4-56\/v1#referee-response-7832","order":1,"name":"referee-response-7832","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"BlueSom France provided funding for this project including the supply of BluePro\u00ae devices free of charge and payment for final manuscript editing by Newmed Publishing Services.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Data associated with the article are available under the terms of the Creative Commons Zero \"No rights reserved\" data waiver (CC0 1.0 Public domain dedication).","order":0,"name":"copyright-info","label":"Copyright"}]}}