{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:10:37Z","timestamp":1772169037828,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.6209.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000}}],"reference-count":87,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>About 200 journal articles reported research on Tourette syndrome and other tic disorders in 2014. Here we briefly summarize a few of the reports that seemed most important or interesting, ranging from animal models to human studies. Readers can comment on our choices or provide their own favorites using the tools on the online article.<\/ns4:p>","DOI":"10.12688\/f1000research.6209.2","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T10:07:18Z","timestamp":1436868438000},"page":"69","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Tourette Syndrome research highlights 2014"],"prefix":"10.12688","volume":"4","author":[{"given":"Cheryl A","family":"Richards","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6921-9567","authenticated-orcid":false,"given":"Kevin J","family":"Black","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"77-90","DOI":"10.1016\/j.neuron.2013.10.052","article-title":"Histidine decarboxylase deficiency causes Tourette syndrome: parallel findings in humans and mice.","volume":"81","author":"L Castellan Baldan","year":"2014","journal-title":"Neuron."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"1186-1187","DOI":"10.1016\/j.neuron.2014.05.023","article-title":"Erratum. 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[Internet]. Distinct cortical and subcortical networks drive myoclonic and vocal tics in the nonhuman primate model of Tourette syndrome: A PET and electrophysiological study","author":"K McCairn","year":"2014"},{"key":"ref-13","doi-asserted-by":"publisher","first-page":"362","DOI":"10.3389\/fnhum.2014.00362","article-title":"Imaging the where and when of tic generation and resting state networks in adult Tourette patients.","volume":"8","author":"I Neuner","year":"2014","journal-title":"Front Hum Neurosci."},{"key":"ref-14","doi-asserted-by":"publisher","first-page":"771-782","DOI":"10.1038\/jcbfm.1994.98","article-title":"Imaging transient, randomly occurring neuropsychological events in single subjects with positron emission tomography: an event-related count rate correlational analysis.","volume":"14","author":"D Silbersweig","year":"1994","journal-title":"J Cereb Blood Flow 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articles."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/4-69\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/4-69\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/4-69\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T14:35:09Z","timestamp":1554215709000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/4-69\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,14]]},"references-count":87,"URL":"https:\/\/doi.org\/10.12688\/f1000research.6209.2","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.7260.r9783","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.7260.r10564","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.7260.r10564","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.7260.r9783","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,14]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/4-69\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.7260.r10564, Davide Martino, Department of Neurology, King's College London, Hospital NHS Foundation Trust, London, UK, 28 Sep 2015, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/4-69\/v2#referee-response-10564","order":0,"name":"referee-response-10564","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.6659.r7989, Barbara Coffey, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA, 29 Apr 2015, version 1, 2 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/4-69\/v1#referee-response-7989","order":1,"name":"referee-response-7989","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Kevin J Black<\/b>; \n<i>Posted: 30 Jun 2015<\/i>; We thank Dr. Coffey for her very thoughtful comments, and have revised the manuscript accordingly. Replies to specific comments follow.\n<b>Requests the \u201capproximate denominator of articles reviewed.\u201d<\/b>We read at least the abstract from the 200 papers identified in the PubMed searches. We have added this number to the introduction. We cite well over 50 of them. Originally we intended to discuss only about 5 or 10 papers, but it was harder than expected to omit anything.&nbsp;\n<b>\u201cIt would be helpful to know how\/why topic areas were chosen \u2026 may reflect the authors\u2019 primary interests\u201d<\/b>Doubtless the selection of articles reflects some influence of our own interests. As you noted, we at least warned the reader that our selection was arbitrary. We attempted to respond to the theme of what reports were most likely to be of greatest interest in the future, and we now explain this choice in the first sentence of Results.&nbsp;\u201c\n<b>Organization of topic areas could be improved\u201d<\/b>Thank you for the useful suggestion. We have rearranged the topics in a more structured fashion:&nbsp;Etiology, pathophysiology, phenomenology and natural history, and treatment.&nbsp;\n<b>We left out pharmacology<\/b>We agree. Please see our comments in the response to Dr. Martino's review&nbsp;about Gilbert \n<i>et al. <\/i>We have added the Malaty and Akbar citation to the treatment section, and the Bachmann \n<i>et al. <\/i>review to Box 2.&nbsp;\n<b>\u201cRelative lack of articles on \u2026 psychiatric comorbidity.\u201d Recommends Hirschtritt <i>et al. <\/i>2015.<\/b>We are also very interested in psychiatric comorbidity, and we agree that the Hirschtritt et al article is very important. As it was published in April, 2015, we added it to Box 2.","URL":"https:\/\/f1000research.com\/articles\/4-69\/v2#referee-comment-1434","order":2,"name":"referee-comment-1434","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.7260.r9783, Valerie C. Brandt, Department for Pediatric and Adult Movement Disorders and Neuropsychiatry, Institute of Neurogenetics, University of L\u00fcbeck, L\u00fcbeck, Germany, 04 Aug 2015, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/4-69\/v2#referee-response-9783","order":3,"name":"referee-response-9783","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Kevin J Black<\/b>; \n<i>Posted: 06 Aug 2015<\/i>; We thank Dr. Brandt for her thoughtful comments.","URL":"https:\/\/f1000research.com\/articles\/4-69\/v2#referee-comment-1508","order":4,"name":"referee-comment-1508","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Kevin J Black<\/b>; \n<i>Posted: 08 Oct 2015<\/i>; We have begun an online draft of a 2015 update of this article, and would be grateful for any constructive feedback. The platform allows readers to leave comments on the little balloon icon at the upper right corner of each section of the&nbsp;article.I'm thinking about allowing &quot;in press&quot; and &quot;Epub ahead of print&quot; articles this year. It has obvious benefits for timeliness, so I should explain why I didn't in the 2014 article above.&nbsp;I did not want to collude with journals that exploit increasing delays in their &quot;official&quot; paper publication dates to increase journal impact factor while simultaneously delaying free access to the public on PubMedCentral. Given&nbsp;the timely publication benefit of F1000Research, such delays increasingly rankle.","URL":"https:\/\/f1000research.com\/articles\/4-69\/v2#article-response-1645","order":5,"name":"article-response-1645","label":"Article Comment","group":{"name":"article-comments","label":"Article Comments"}},{"value":"<b>Kevin J Black<\/b>; \n<i>Posted: 19 Jul 2015<\/i>; I omitted this citation for the matplotlib library used in creating Figure 1:Hunter JD:&nbsp;Matplotlib: A 2D graphics environment. Computing In Science &amp; Engineering 9(3):90-95, 2007.","URL":"https:\/\/f1000research.com\/articles\/4-69\/v2#article-response-1470","order":6,"name":"article-response-1470","label":"Article Comment","group":{"name":"article-comments","label":"Article Comments"}},{"value":"This work was supported in part by the U.S. National Institutes of Health (NIH), grant R21 NS091635, and by the McDonnell Center for Systems Neuroscience at Washington University. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":7,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Data associated with the article are available under the terms of the Creative Commons Zero \"No rights reserved\" data waiver (CC0 1.0 Public domain dedication).","order":0,"name":"copyright-info","label":"Copyright"}]}}