{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:24:58Z","timestamp":1793294698265,"version":"4.5.0"},"reference-count":13,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T00:00:00Z","timestamp":1434585600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    Since the discovery in the early 1980s that 1-octen-3-ol, isolated from oxen breath, attracts tsetse fly, there has been growing interest in exploring the use of this semiochemical as a possible generic lure for trapping host-seeking mosquitoes. Intriguingly, traps baited with 1-octen-3-ol captured significantly more females of the malaria mosquito,\n                    <ns4:italic>Anopheles gambiae<\/ns4:italic>\n                    , and the yellow fever mosquito,\n                    <ns4:italic>Aedes aegypti,<\/ns4:italic>\n                    than control traps, but failed to attract the southern house mosquito,\n                    <ns4:italic>Culex quinquefasciatus<\/ns4:italic>\n                    . Additionally, it has been demonstrated that this attractant is detected with enantioselective odorant receptors (ORs) expressed only in maxillary palps. On the basis of indoor behavioral assays it has even been suggested that 1-octen-3-ol might be a repellent to the southern house mosquito. Our approach was two-prong, i.e., to isolate 1-octen-3-ol-sensitive ORs expressed in maxillary palps and antennae of southern house female mosquito, and test the hypothesis that this semiochemical is a repellent. An OR with high transcript levels in maxillary palps, CquiOR118b, showed remarkable selectivity towards (\n                    <ns4:italic>R<\/ns4:italic>\n                    )-1-octen-3-ol, whereas an OR expressed in antennae, CquiOR114b, showed higher preference for (\n                    <ns4:italic>S<\/ns4:italic>\n                    )-1-octen-3-ol than its antipode. Repellency by a surface landing and feeding assay showed that not only racemic, but enantiopure (\n                    <ns4:italic>R<\/ns4:italic>\n                    )- and (\n                    <ns4:italic>S<\/ns4:italic>\n                    )-1-octen-3-ol are repellents at 1% dose thus suggesting the occurrence of other (\n                    <ns4:italic>S<\/ns4:italic>\n                    )-1-octen-3-ol-sensitive OR(s). Female mosquitoes with ablated maxillary palps were repelled by 1-octen-3-ol, which implies that in addition to OR(s) in the maxillary palps, antennal OR(s) are essential for repellency activity.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.6646.1","type":"journal-article","created":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T10:15:15Z","timestamp":1434622515000},"page":"156","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":71,"title":["1-Octen-3-ol \u2013 the attractant that repels"],"prefix":"10.12688","volume":"4","author":[{"given":"Pingxi","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garrison K.","family":"Buss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter S.","family":"Leal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2015,6,18]]},"reference":[{"key":"ref-1","first-page":"263-71","article-title":"About the fragrances of matsutake.","volume":"30","author":"S Murahashi","year":"1936","journal-title":"Sci Pap Inst Phys Chem Res."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"335-9","DOI":"10.1017\/S1742758400008626","article-title":"1-Octen-3-ol. A potent olfactory stimulant and attractant for tsetse isolated from cattle odours.","volume":"5","author":"D Hall","year":"1984","journal-title":"Insect Sci Applic."},{"key":"ref-3","first-page":"311-6","article-title":"Carbon dioxide and 1-octen-3-ol as mosquito attractants.","volume":"5","author":"W Takken","year":"1989","journal-title":"J Am Mosq Control Assoc."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"323-31","DOI":"10.1111\/j.1365-2915.2007.00697.x","article-title":"Evaluation of the enantiomers of 1-octen-3-ol and 1-octyn-3-ol as attractants for mosquitoes associated with a freshwater swamp in Florida, U.S.A.","volume":"21","author":"D Kline","year":"2007","journal-title":"Med Vet Entomol."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"727-38","DOI":"10.1093\/chemse\/bjm040","article-title":"Maxillary palps are broad spectrum odorant detectors in Culex quinquefasciatus.","volume":"32","author":"Z Syed","year":"2007","journal-title":"Chem Senses."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"1533-44","DOI":"10.1016\/j.cub.2007.07.062","article-title":"Odor coding in the maxillary palp of the malaria vector mosquito Anopheles gambiae.","volume":"17","author":"T Lu","year":"2007","journal-title":"Curr Biol."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"541-50","DOI":"10.1017\/S0007485311000162","article-title":"Enantiomeric selectivity in behavioural and electrophysiological responses of Aedes aegypti and Culex quinquefasciatus mosquitoes.","volume":"101","author":"J Cook","year":"2011","journal-title":"Bull Entomol Res."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"e21785","DOI":"10.1371\/journal.pone.0021785","article-title":"Functional characterization of the octenol receptor neuron on the maxillary palps of the yellow fever mosquito, Aedes aegypti.","volume":"6","author":"A Grant","year":"2011","journal-title":"PloS One."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"e7032","DOI":"10.1371\/journal.pone.0007032","article-title":"Characterization of an enantioselective odorant receptor in the yellow fever mosquito Aedes aegypti.","volume":"4","author":"J Bohbot","year":"2009","journal-title":"PloS One."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"16592-7","DOI":"10.1073\/pnas.1417244111","article-title":"Mosquito odorant receptor for DEET and methyl jasmonate.","volume":"111","author":"P Xu","year":"2014","journal-title":"Proc Natl Acad Sci U S A."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"18704-9","DOI":"10.1073\/pnas.1316059110","article-title":"Differential expression of olfactory genes in the southern house mosquito and insights into unique odorant receptor gene isoforms.","volume":"110","author":"W Leal","year":"2013","journal-title":"Proc Natl Acad Sci U S A."},{"key":"ref-12","doi-asserted-by":"publisher","DOI":"10.1111\/imb.12176","article-title":"Molecular basis for odorant receptor tuning: a short C-terminal sequence is necessary and sufficient for selectivity of mosquito Or8.","author":"S Hill","year":"2015","journal-title":"Insect Mol Biol."},{"key":"ref-13","doi-asserted-by":"publisher","DOI":"10.5256\/f1000research.6646.d49878","article-title":"Dataset 1 in: 1-Octen-3-ol \u2013 the attractant that repels.","author":"W Leal","year":"2015","journal-title":"F1000Research."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/4-156\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/4-156\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/4-156\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T07:35:58Z","timestamp":1543995358000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/4-156\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,18]]},"references-count":13,"URL":"https:\/\/doi.org\/10.12688\/f1000research.6646.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.7140.r9111","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.7140.r9112","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.7140.r9109","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.7140.r9110","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.7140.r9110","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.7140.r9111","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.7140.r9112","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.7140.r9109","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,18]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/4-156\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.7140.r9112, Joseph C. Dickens, Invasive Insect Biocontrol and Behaviour Laboratory, United States Department of Agriculture, Beltsville, MD, USA, 29 Jun 2015, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/4-156\/v1#referee-response-9112","order":0,"name":"referee-response-9112","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.7140.r9109, Jeffery K. Tomberlin, Department of Entomology, Texas A&M University, College Station, TX, USA, 01 Jul 2015, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/4-156\/v1#referee-response-9109","order":1,"name":"referee-response-9109","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.7140.r9110, Wynand van der Goes van Naters, School of Biosciences, Cardiff University, Cardiff, UK, 02 Jul 2015, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/4-156\/v1#referee-response-9110","order":2,"name":"referee-response-9110","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.7140.r9111, Kenneth F. Haynes, Department of Entomology, University of Kentucky, Lexington, KY, USA, 02 Jul 2015, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/4-156\/v1#referee-response-9111","order":3,"name":"referee-response-9111","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This work was supported in part by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under award R01AI095514. FZ sabbatical leave at UC Davis was supported in part by the Chinese Scholarship Council. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Data associated with the article are available under the terms of the Creative Commons Zero \"No rights reserved\" data waiver (CC0 1.0 Public domain dedication).","order":0,"name":"copyright-info","label":"Copyright"}]}}