{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:38:35Z","timestamp":1791909515120,"version":"4.3.4"},"reference-count":18,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T00:00:00Z","timestamp":1437609600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Japanese encephalitis (JE) is the leading cause of viral encephalitis in Asia. Acute encephalitis syndrome (AES) is a group of central nervous system (CNS) disorders caused by a wide range of viruses, bacteria, fungi, chemicals and toxins. It is important to distinguish between various forms of infectious encephalitis with similar clinical manifestations in order to ensure specific and accurate diagnosis and development of subsequent therapeutic strategies. Cerebrospinal fluid (CSF) is in direct contact with the CNS and hence it is considered to be an excellent source for identifying biomarkers for various neurological disorders. With the recent advancement in proteomic methodologies, the field of biomarker research has received a remarkable boost.\u00a0 The present study identifies potential biomarkers for JE using a proteomics based approach. The CSF proteomes from ten patients each with JE and Non-JE acute encephalitis were analyzed by 2D gel electrophoresis followed by mass spectrometry. Vitamin D-binding protein (DBP), fibrinogen gamma chain, fibrinogen beta chain, complement C4-B, complement C3 and cytoplasmic actin were found to be significantly elevated in case of JE indicating severe disruption of the blood brain barrier and DBP can be suggested to be an important diagnostic marker.<\/ns4:p>","DOI":"10.12688\/f1000research.6801.1","type":"journal-article","created":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T09:25:08Z","timestamp":1437643508000},"page":"334","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Cerebrospinal Fluid Biomarkers of Japanese 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Banerjea, Laboratory of Virology, National Institute of Immunology, New Delhi, Delhi, India, 29 Jul 2015, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/4-334\/v1#referee-response-9697","order":0,"name":"referee-response-9697","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.7311.r9714, Anil Kumar, Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, USA, 30 Jul 2015, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/4-334\/v1#referee-response-9714","order":1,"name":"referee-response-9714","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.7311.r9609, Daniel R\u016f\u017eek, Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, \u010cesk\u00e9 Bud\u011bjovice, Czech Republic, 31 Jul 2015, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/4-334\/v1#referee-response-9609","order":2,"name":"referee-response-9609","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"AB is awarded the Tata Innovation Fellowship (ABS\/DBT\/0515\/062) from the Department of Biotechnology. The project is also funded by National Brain Research Centre core funding. RK is funded by a grant from NBRC. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Data associated with the article are available under the terms of the Creative Commons Zero \"No rights reserved\" data waiver (CC0 1.0 Public domain dedication).","order":0,"name":"copyright-info","label":"Copyright"}]}}