{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:05:56Z","timestamp":1788379556646,"version":"build-2803163510"},"reference-count":80,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T00:00:00Z","timestamp":1440374400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Background: Dermatoglyphic studies, particularly those arising from the Dutch Hunger Winter Families Cohort, indicate an involvement of prenatal epigenetic insults in type-2 diabetes. However, the exact orchestration of this association is not fully understood. Herein is described a meta-analysis performed based on a belief that such an approach could shed some light as to the role of genetic &amp; epigenetic influences in the etiology of type-2 diabetes.<\/ns4:p>\n                  <ns4:p\/>\n                  <ns4:p>Methodology\/principal findings: The study incorporated reports identified from PubMed, Medline, &amp; Google Scholar databases for eligible case-control studies that assessed dermatoglyphics in type-2 diabetes cases relative to controls. Over 44,000 fingerprints &amp; 2300 palm prints from around 4400 individuals were included in the analysis. Decreased loops patterns [OR= 0.76; 95% CI= (0.59, 0.98)], increased non-loop patterns [OR= 1.31; 95% CI= (1.02, 1.68)], and reduced absolute finger ridge counts [OR= -0.19; 95% CI= (-0.33, -0.04)] were significant findings among the diabetic group. These results are indicative of mild developmental deviances, with epigenetic insults significantly linked to early gestation wherein critical events &amp;signaling pathways of the endocrine pancreas development are witnessed. Further, the increased loop patterns with decreased non-loop patterns were deemed as possible indicators of decreased genomic heterozygosity with concurrently increased homozygosity in the diabetic group, linked to reduced buffering capacities during prenatal development.<\/ns4:p>\n                  <ns4:p\/>\n                  <ns4:p>\n                    Conclusions: Epigenetic insults primarily during the 1\n                    <ns4:sup>st<\/ns4:sup>\n                    trimester, to a lesser extent between the early-to-mid 2\n                    <ns4:sup>nd<\/ns4:sup>\n                    trimester, but least likely linked to those beyond the mid-second trimester are evident in type-2 diabetes. It is recommended that future research aimed at expounding the prenatal origins of T2DM, as well as developing novel therapeutic methods, should focus on the early stages of endocrine pancreatic development.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.6923.1","type":"journal-article","created":{"date-parts":[[2015,8,24]],"date-time":"2015-08-24T06:05:03Z","timestamp":1440396303000},"page":"617","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Dermatoglyphic meta-analysis indicates early epigenetic outcomes &amp; possible implications on genomic zygosity in type-2 diabetes"],"prefix":"10.12688","volume":"4","author":[{"given":"Seile","family":"Yohannes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2015,8,24]]},"reference":[{"key":"ref-1","first-page":"32-49","article-title":"IDF Diabetes Atlas (6th ed.)","year":"2013"},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"S290-6","DOI":"10.2337\/dc08-s271","article-title":"Is type 2 diabetes an operable intestinal disease? 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