{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:10:44Z","timestamp":1772169044301,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.73054.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000}},{"DOI":"10.12688\/f1000research.73054.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000}}],"reference-count":27,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    <ns3:bold>Background:\u00a0<\/ns3:bold>\n                    The gene\u00a0\n                    <ns3:italic>FOXO3a<\/ns3:italic>\n                    \u00a0has been elucidated to govern the development of\u00a0chronic\u00a0granulocytic\u00a0leukemia\u00a0(CGL). Moreover,\u00a0it has been suggested that\u00a0the levels of\u00a0\n                    <ns3:italic>FOXO3a<\/ns3:italic>\n                    \u00a0in circulation\u00a0are\u00a0affected by\u00a0the\n                    <ns3:italic>\u00a0FOXO3a<\/ns3:italic>\n                    \u00a0rs4946936\u00a0gene polymorphism. However, no study\u00a0has\u00a0assessed the correlation between\u00a0the\u00a0\n                    <ns3:italic>FOXO3a<\/ns3:italic>\n                    \u00a0rs4946936\u00a0gene polymorphism and the levels of\n                    <ns3:italic>\u00a0FOXO3a<\/ns3:italic>\n                    .\u00a0The objective of this study was to assess the association between the\u00a0\n                    <ns3:italic>FOXO3a<\/ns3:italic>\n                    \u00a0rs4946936\u00a0gene polymorphism and the levels of\u00a0\n                    <ns3:italic>FOXO3a<\/ns3:italic>\n                    \u00a0in CGL patients treated with imatinib mesylate.\u00a0\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Methods:<\/ns3:bold>\n                    A cross-sectional study was conducted\u00a0from\u00a0February 2019\u00a0to\u00a0February 2020. The genotyping of\u00a0\n                    <ns3:italic>FOXO3a<\/ns3:italic>\n                    \u00a0rs4946936\u00a0gene polymorphism was conducted using PCR-RFLP, and the levels of\u00a0\n                    <ns3:italic>FOXO3a<\/ns3:italic>\n                    \u00a0were\u00a0assessed using ELISA. The association between the\u00a0\n                    <ns3:italic>FOXO3a<\/ns3:italic>\n                    \u00a0rs4946936\u00a0gene polymorphism and the levels of\u00a0\n                    <ns3:italic>FOXO3a<\/ns3:italic>\n                    \u00a0were\u00a0assessed using multiple logistic regression.\u00a0\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Results:<\/ns3:bold>\n                    \u00a0A total of 60 CGL patients\u00a0were\u00a0assessed\u00a0in our study. Among them, the CC, CT, and TT genotypes of\u00a0the\u00a0\n                    <ns3:italic>FOXO3a<\/ns3:italic>\n                    \u00a0rs4946936\u00a0gene polymorphism were\u00a035.0%,\u00a048.3%,\u00a0and\u00a016.7% respectively. Our calculation revealed that elevated levels of\u00a0\n                    <ns3:italic>FOXO3a<\/ns3:italic>\n                    \u00a0were\u00a0found in CGL patients with\u00a0the\u00a0CC genotype\u00a0of\u00a0the\u00a0\n                    <ns3:italic>FOXO3a<\/ns3:italic>\n                    \u00a0rs4946936\u00a0gene polymorphism. While we failed to clarify the association between either\u00a0the\u00a0CT\u00a0or\u00a0the\u00a0TT genotype\u00a0of\u00a0\n                    <ns3:italic>FOXO3a<\/ns3:italic>\n                    \u00a0rs4946936\u00a0gene polymorphism\u00a0and the levels of\u00a0\n                    <ns3:italic>FOXO3a<\/ns3:italic>\n                    .\u00a0\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Conclusion:<\/ns3:bold>\n                    Our study identifies that\u00a0the\u00a0CC genotype of\u00a0the\u00a0\n                    <ns3:italic>FOXO3a<\/ns3:italic>\n                    \u00a0rs4946936\u00a0gene polymorphism affects the elevated levels of\u00a0\n                    <ns3:italic>FOXO3a<\/ns3:italic>\n                    \u00a0in CGL patients treated with imatinib mesylate.\n                  <\/ns3:p>","DOI":"10.12688\/f1000research.73054.3","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T10:40:07Z","timestamp":1649673607000},"page":"1003","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The association between\u00a0FOXO3a\u00a0rs4946936 gene polymorphism and the levels of\u00a0FOXO3a\u00a0among\u00a0chronic\u00a0granulocytic\u00a0leukemia patients treated with imatinib mesylate"],"prefix":"10.12688","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8889-0930","authenticated-orcid":false,"given":"Shinta 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