{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T02:56:28Z","timestamp":1772852188595,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.73188.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000}}],"reference-count":24,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Introduction:\u00a0<\/ns4:p>\n                  <ns4:p>Asthma is the most common chronic respiratory disease during pregnancy. However, reports of new onset asthma during pregnancy are lacking. We report two cases of new onset asthma during pregnancy following respiratory tract infection, subsequently one case with\u00a0M.\u00a0pneumoniae\u00a0infection and the other case with a combined infection with respiratory syncytial virus and rhinovirus.\u00a0\u00a0<\/ns4:p>\n                  <ns4:p>Case presentation:\u00a0\u00a0<\/ns4:p>\n                  <ns4:p>Both patients presented with the clinical features of an acute asthma exacerbation during pregnancy\u00a0without a medical history of asthma. During follow up the diagnosis of asthma was supported by\u00a0spirometry\u00a0showing\u00a0significant reversibility and\u00a0elevated\u00a0fractional exhaled nitric oxide (FeNO).\u00a0Patients\u00a0were hospitalized and\u00a0received supplemental oxygen, treatment for\u00a0an\u00a0acute\u00a0asthma exacerbation\u00a0with\u00a0systemic\u00a0corticosteroids, high dose\u00a0inhalation therapy.\u00a0These\u00a0therapeutic interventions subsequently led to a good outcome for the mother and\u00a0newborn\u00a0in both cases.\u00a0\u00a0<\/ns4:p>\n                  <ns4:p>Conclusions:\u00a0<\/ns4:p>\n                  <ns4:p>New onset asthma should be part of the differential diagnosis in pregnant patients with respiratory symptoms, particularly in case of mycoplasma infection.\u00a0<\/ns4:p>\n                  <ns4:p>Diagnosing asthma during pregnancy can be challenging. In these circumstances, additional diagnostic tests (like inflammatory biomarkers FeNO and blood eosinophils) can be helpful to support the diagnosis.<\/ns4:p>","DOI":"10.12688\/f1000research.73188.2","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T12:40:08Z","timestamp":1677674408000},"page":"1120","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["New onset asthma during\u00a0pregnancy:\u00a0two case reports"],"prefix":"10.12688","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0210-8712","authenticated-orcid":false,"given":"Paula S.","family":"Schriek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saar A.","family":"Bendien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanneke A.","family":"Feitsma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeroen","family":"van Exsel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2023,3,1]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"140-3","DOI":"10.1016\/j.ijgo.2010.05.024","article-title":"Frequency of asthma as the cause of dyspnea in pregnancy.","volume":"111","author":"K Bidad","year":"2010","journal-title":"Int J Gynaecol Obstet."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"1901335","DOI":"10.1183\/13993003.01335-2019","article-title":"Effect of asthma exacerbation during pregnancy in women with asthma: a population-based cohort study.","volume":"55","author":"K Abdullah","year":"2020","journal-title":"Eur Respir 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Racicot","year":"2014","journal-title":"Am J Reprod Immunol."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"469-482","DOI":"10.1038\/nri.2017.64","article-title":"The unique immunological and microbial aspects of pregnancy.","volume":"17","author":"G Mor","year":"2017","journal-title":"Nat Rev Immunol."},{"key":"ref-8","article-title":"Global strategy for asthma management and prevention","year":"2019"},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"100-4","DOI":"10.1136\/pgmj.2006.049023","article-title":"Mycoplasma pneumoniae and its role in asthma.","volume":"83","author":"N Nisar","year":"2007","journal-title":"Postgrad Med J."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"1348-53","DOI":"10.1164\/ajrccm.149.5.8173777","article-title":"Association of Mycoplasma pneumoniae antigen with initial onset of bronchial asthma.","volume":"149","author":"T Yano","year":"1994","journal-title":"Am J Respir Crit Care 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favourable cytokine environment necessary for pregnancy success.","volume":"89","author":"K Hadfield","year":"2011","journal-title":"J Reprod Immunol."},{"key":"ref-15","doi-asserted-by":"publisher","first-page":"545-565","DOI":"10.1016\/S0889-8561(02)00009-7","article-title":"Immunology of implantation.","volume":"22","author":"G Mor","year":"2002","journal-title":"Immunology and Allergy Clinics of North America."},{"key":"ref-16","doi-asserted-by":"publisher","first-page":"827-33","DOI":"10.1111\/resp.12068","article-title":"Alterations in inflammatory, antiviral and regulatory cytokine responses in peripheral blood mononuclear cells from pregnant women with asthma.","volume":"18","author":"R Vanders","year":"2013","journal-title":"Respirology."},{"key":"ref-17","doi-asserted-by":"publisher","first-page":"159-64","DOI":"10.1016\/j.rmed.2010.11.006","article-title":"Asthma in pregnancy--immunological changes and clinical management.","volume":"105","author":"L Tamasi","year":"2011","journal-title":"Respir Med."},{"key":"ref-18","doi-asserted-by":"publisher","first-page":"m3320","DOI":"10.1136\/bmj.m3320","article-title":"Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis.","volume":"370","author":"J Allotey","year":"2020","journal-title":"BMJ."},{"key":"ref-19","doi-asserted-by":"publisher","first-page":"764-768","DOI":"10.1016\/j.ajog.2020.07.045","article-title":"Are clinical outcomes worse for pregnant women at \u226520 weeks' gestation infected with coronavirus disease 2019? 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