{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:09:36Z","timestamp":1772168976852,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.75090.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000}}],"reference-count":31,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T00:00:00Z","timestamp":1659398400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014538","name":"Lembaga Pengelola Dana Pendidikan","doi-asserted-by":"publisher","award":["PRJ-80\/LPDP\/2019"],"award-info":[{"award-number":["PRJ-80\/LPDP\/2019"]}],"id":[{"id":"10.13039\/501100014538","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    <ns3:bold>Background<\/ns3:bold>\n                    : The objective of this study was to test the validity of automated audiometry as a method of hearing examination in patients with multidrug-resistant tuberculosis.\n                    <ns3:bold\/>\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Method<\/ns3:bold>\n                    <ns3:bold>s<\/ns3:bold>\n                    : This was a cross-sectional comparative study with a retrospective approach, using patient medical records. Patients with multidrug-resistant tuberculosis (MDR-TB) were recruited based-on medical records that met the inclusion and exclusion criteria at the Pulmonology outpatient unit, then referred to the Otorhinolaryngology outpatient unit of the Dr. Soetomo Academic Medical Center. The subjects\u2019 hearing function was measured with two different devices (automated audiometer and conventional audiometer) before being given anti-tuberculosis drug therapy (aminoglycoside injection) as ototoxicity monitoring from July to December 2019 period. Sensitivity and specificity analysis was used to assess the validity of the test.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Results<\/ns3:bold>\n                    : A total of 36 patients (72 ears) were included. The comparison test results using the Mann-Whitney test showed that there were significant differences between automated audiometry and conventional audiometry in both ears. Analysis values were: sensitivity 80-97%, specificity 37-96%, positive predictive value 74-98%, and negative predictive value 59-96%.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Conclusion<\/ns3:bold>\n                    <ns3:bold>s<\/ns3:bold>\n                    : Automated audiometry is valid for use as a method of hearing examination and monitoring in patients with multidrug-resistant tuberculosis.\n                  <\/ns3:p>","DOI":"10.12688\/f1000research.75090.2","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T06:58:00Z","timestamp":1659423480000},"page":"1277","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Validity of automated audiometry for hearing examination in patients with multidrug-resistant tuberculosis"],"prefix":"10.12688","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9572-2679","authenticated-orcid":false,"given":"Nyilo","family":"Purnami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rian W.","family":"Palandeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soedarsono","family":"-","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhany","family":"Arifianto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Seok","family":"Moon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2022,8,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"119-120","DOI":"10.4103\/jgid.jgid_125_17","article-title":"The threat of multidrug-resistant tuberculosis.","volume":"10","author":"R Paul","year":"2018","journal-title":"J. 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Jenkins, Department of Otolaryngology, University of Colorado School of Medicine, Aurora, CO, USA, 02 Feb 2022, version 1, 1 approved, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/10-1277\/v1#referee-response-115235","order":0,"name":"referee-response-115235","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Nyilo Purnami<\/b>; \n<i>Posted: 03 Feb 2022<\/i>; Thank you very much.","URL":"https:\/\/f1000research.com\/articles\/10-1277\/v2#referee-comment-7773","order":1,"name":"referee-comment-7773","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.136850.r146234, Jackie L. Clark, Callier Center for Communication Disorders, University of Texas at Dallas, Dallas, TX, USA, 12 Sep 2022, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/10-1277\/v2#referee-response-146234","order":2,"name":"referee-response-146234","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This work was supported by Lembaga Pengelola Dana Pendidikan (LPDP) Rispro (Grant No.PRJ-80\/LPDP\/2019; to Soedarsono and Dhany Arifianto). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}