{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:11:07Z","timestamp":1772169067291,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.75630.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000}}],"reference-count":41,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns7:p>\n                    Background Ethical dilemmas can occur in any situation in clinical medicine. In patients undergoing neuro-anesthesia for surgical procedure evacuation of intracerebral hemorrhage with a history of hemorrhagic stroke, anticoagulants should not be given because they can cause recurrent bleeding. Meanwhile, at the same time, the patient could also be infected with coronavirus disease 2019 (COVID-19), one of treatment is the administration of anticoagulants. Methods A case report. A 46-year-old male patient was admitted to hospital with a loss of consciousness and was diagnosed with intracerebral hemorrhage due to a hemorrhagic stroke and was confirmed positive for COVID-19. Giving anticoagulants to patients is considered counterproductive so, an ethical dilemma arises. For this reason, a joint conference was held to obtain the best ethical and medicolegal solutions for the patient. Results By using several methods of resolving ethical dilemmas such as basic ethical principles, supporting ethical principles, and medicolegal considerations, it was decided that the patient was not to be given anticoagulants. Conclusions Giving anticoagulants to hemorrhagic stroke patients is dangerous even though it is beneficial for COVID-19 patients, so here the principle of risk-benefit balance is applied to patients who prioritize risk prevention rather than providing benefits. This is also supported by the\n                    <ns7:italic>prima facie<\/ns7:italic>\n                    principle by prioritizing the principle of non-maleficence rather than beneficence, the\n                    <ns7:italic>minus malum<\/ns7:italic>\n                    principle by seeking the lowest risk, and the double effect principle by making the best decision even in a slightly less favorable way as well as the medicolegal aspect by assessing patient safety and risk management.\n                  <\/ns7:p>","DOI":"10.12688\/f1000research.75630.2","type":"journal-article","created":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T06:45:38Z","timestamp":1702363538000},"page":"1303","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Case report: Administration of anticoagulant therapy after neuro-anesthesia procedure for hemorrhagic stroke patients with COVID-19 complications and its ethical and medicolegal consideration"],"prefix":"10.12688","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2069-7119","authenticated-orcid":false,"given":"Taufik","family":"Suryadi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8171-6710","authenticated-orcid":false,"given":"Kulsum","family":"Kulsum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2023,12,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"634-634A","DOI":"10.2471\/BLT.16.181636","article-title":"Stroke: A global response is needed.","volume":"94","author":"W Johnson","year":"2016","journal-title":"Bull. 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Soufi","year":"2020","journal-title":"Appl Sci."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"206-216","DOI":"10.1016\/j.ijsu.2020.04.001","article-title":"Evidence- based management guideline for the COVID-19 pandemic - Review article.","volume":"77","author":"M Nicola","year":"2020","journal-title":"Int J Surg."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"217-220","DOI":"10.1097\/JCMA.0000000000000270","article-title":"The outbreak of COVID-19 -An overview.","volume":"83","author":"Y Wu","year":"2020","journal-title":"J Chin Med Assoc."},{"key":"ref24","article-title":"Total number of deaths from COVID-19 in Indonesia as of November 18, 2021.","author":"H Wolff"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"119-129","DOI":"10.36497\/jri.v40i2.101","article-title":"Coronavirus disease 2019.","volume":"40","author":"D Handayani","year":"2020","journal-title":"J Resp 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practice.","volume":"30","author":"B Varkey","year":"2021","journal-title":"Med Princ Pract."},{"key":"ref31","first-page":"2565-2570","article-title":"Stage III-B cervical-cancer of young age in medical, bioethics, and clinical ethics perspectives.","volume":"14","author":"N Mappaware","year":"2020","journal-title":"Indian J Forens Med Toxicol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"111-116","DOI":"10.1136\/medethics-2014-102282","article-title":"Defending the four principles approach as a good basis for good medical practice and therefore for good medical ethics.","volume":"41","author":"R Gillon","year":"2015","journal-title":"J Med Ethics."},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1-8","DOI":"10.1186\/1472-6939-13-10","article-title":"The four principles: Can they be measured and do they predict ethical decision making?.","volume":"13","author":"K Page","year":"2012","journal-title":"BMC Med Ethics."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"822-828","DOI":"10.18203\/2394-6040.ijcmph20180738","article-title":"Understanding the principles of ethics in health care: a systematic analysis of qualitative information.","volume":"5","author":"V Kemparaj","year":"2018","journal-title":"Int J Community Med Public Heal."},{"key":"ref35","first-page":"205-211","article-title":"The doctrine of double effect, a review for the bedside nurse providing end of life care.","author":"D Wholihan","year":"2017","journal-title":"J Hosp Palliat Nurs."},{"key":"ref37","first-page":"638-643","article-title":"Risk management in anesthesia.","volume":"75","author":"L Cabrini","year":"2009","journal-title":"Minerva anesthesiologica."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"15-19","DOI":"10.12691\/ajcmr-6-1-4","article-title":"Risk assessment in surgical patients: American Society of Anesthesiologists (ASA) classification vs. intraoperative therapeutic and 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