{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:45:50Z","timestamp":1793241950953,"version":"4.5.0"},"reference-count":81,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T00:00:00Z","timestamp":1455148800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    The microaerophilic protist parasite\n                    <ns4:italic>Trichomonas vaginalis<\/ns4:italic>\n                    is occurring globally and causes infections in the urogenital tract in humans, a condition termed trichomoniasis. In fact, trichomoniasis is the most prevalent non-viral sexually transmitted disease with more than 250 million people infected every year. Although trichomoniasis is not life threatening in itself, it can be debilitating and increases the risk of adverse pregnancy outcomes, HIV infection, and, possibly, neoplasias in the prostate and the cervix. Apart from its role as a pathogen,\n                    <ns4:italic>T<\/ns4:italic>\n                    .\n                    <ns4:italic>vaginalis<\/ns4:italic>\n                    is also a fascinating organism with a surprisingly large genome for a parasite,\n                    <ns4:italic>i<\/ns4:italic>\n                    .\n                    <ns4:italic>e<\/ns4:italic>\n                    . larger than 160 Mb, and a physiology adapted to its microaerophilic lifestyle. In particular, the hydrogenosome, a mitochondria-derived organelle that produces hydrogen, has attracted much interest in the last few decades and rendered\n                    <ns4:italic>T<\/ns4:italic>\n                    .\n                    <ns4:italic>vaginalis<\/ns4:italic>\n                    a model organism for eukaryotic evolution.\n                  <\/ns4:p>\n                  <ns4:p>\n                    This review will give a succinct overview of the major advances in the\n                    <ns4:italic>T<\/ns4:italic>\n                    .\n                    <ns4:italic>vaginalis<\/ns4:italic>\n                    field in the last few years.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.7594.1","type":"journal-article","created":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T11:50:52Z","timestamp":1455191452000},"page":"162","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":57,"title":["Recent Advances in the Trichomonas vaginalis Field"],"prefix":"10.12688","volume":"5","author":[{"given":"David","family":"Leitsch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2016,2,11]]},"reference":[{"key":"ref-1","article-title":"Global incidence and prevalence of selected curable sexually transmitted infections \u2013 2008","year":"2016"},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1186\/s12879-015-1055-0","article-title":"Trichomonas vaginalis: a review of epidemiologic, clinical and treatment issues.","volume":"15","author":"P 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