{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:11:08Z","timestamp":1772169068835,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.76181.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000}}],"reference-count":32,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background:<\/ns4:bold>\n                    Coronavirus disease 2019 (COVID-19) requires mass\n                    <ns4:bold\/>\n                    immunization\n                    <ns4:bold\/>\n                    to control the severity of symptoms and global spread. Data from developed countries have shown a high prevalence of parental COVID-19 vaccine hesitancy. However, parental vaccine hesitancy data in low- and middle-income countries are scarce. This study aimed to assess the prevalence of parental vaccine hesitancy and identify subgroups with higher odds of vaccine hesitancy in parents in Bangladesh.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Methods:<\/ns4:bold>\n                    A cross-sectional study was conducted on the parents of children aged &lt;18 years from October 10, 2021 to October 31, 2021. Parents participated in face-to-face interviews in randomly selected locations in Bangladesh using a vaccine hesitancy questionnaire. Factors associated with COVID-19 vaccine hesitancy were identified using binary logistic regression analysis.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Results:<\/ns4:bold>\n                    Data from 2,633 eligible parents were analyzed. Overall, 42.8% reported COVID-19 vaccine hesitancy for their youngest child. The final model suggested the following factors were associated with hesitancy: children's age; parent's age, religion, occupation, monthly household income, permanent address, living location, status of tobacco use, adherence with regular government vaccination programs (other than COVID-19), perceptions of\u00a0COVID-19 vaccine efficacy among Bangladeshi children, self-vaccination intentions, reported family members' illness or death from COVID-19, and perceived threat of COVID-19 were the independent predictors of parental COVID-19 vaccine hesitancy. Conversely, participants who were not tobacco users, parents who were very likely to believe that their children or family members could be infected with COVID-19 in the following year and who were very concerned about their children or a family member contracting COVID-19 in the next year had significantly lower odds of COVID-19 vaccine hesitancy.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusions:<\/ns4:bold>\n                    Our study suggested that vaccine hesitation varied based on sociodemographic characteristics, religion, behavior, and perceived COVID-19 threat. Therefore, interventions focused on addressing vaccine hesitancy among specific subgroups are warranted.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.76181.2","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T06:45:06Z","timestamp":1646203506000},"page":"90","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Parental coronavirus disease vaccine hesitancy for children in Bangladesh: a cross-sectional study"],"prefix":"10.12688","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4685-5050","authenticated-orcid":false,"given":"Mohammad","family":"Ali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sohel","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atia Sharmin","family":"Bonna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1383-3733","authenticated-orcid":false,"given":"Abu-sufian","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Ariful","family":"Islam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania Akter","family":"Urmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tasnuva Samarukh","family":"Proma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e26-e35","DOI":"10.1016\/S1473-3099(20)30773-8","article-title":"What defines an efficacious COVID-19 vaccine? A review of the challenges assessing the clinical efficacy of vaccines against SARS-CoV-2.","volume":"21","author":"S Hodgson","year":"2021 Feb 1 cited 2022 Jan 13","journal-title":"Lancet Infect. Dis."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"737-741","DOI":"10.1016\/j.immuni.2020.04.012","article-title":"Herd Immunity: Understanding COVID-19.","volume":"52","author":"H Randolph","year":"2020 cited 2021 Oct 28","journal-title":"Immunity."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1186\/s12889-021-11725-5","article-title":"Parental COVID-19 vaccine hesitancy for children: vulnerability in an urban hotspot.","volume":"21","author":"N Alfieri","year":"2021 Dec 13 cited 2021 Oct 28","journal-title":"BMC Public Health."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"4161-4164","DOI":"10.1016\/j.vaccine.2015.04.036","article-title":"Vaccine hesitancy: Definition, scope and determinants.","volume":"33","author":"N MacDonald","year":"2015 Aug 14 cited 2021 Jan 16","journal-title":"Vaccine."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"101113","DOI":"10.1016\/j.eclinm.2021.101113","article-title":"Attitudes, acceptance and hesitancy among the general population worldwide to receive the COVID-19 vaccines and their contributing factors: A systematic review.","volume":"40","author":"F Cascini","year":"2021 Oct cited 2021 Oct 29","journal-title":"iScience."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1665-1684","DOI":"10.1016\/j.toxrep.2021.08.010","article-title":"Why are we vaccinating children against COVID-19?.","volume":"8","author":"R Kostoff","year":"2021 Jan 1","journal-title":"Toxicol. Rep."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.3390\/vaccines9101115","article-title":"COVID-19 Vaccine Hesitancy among Parents of Children and Adolescents Living in Brazil.","volume":"9","author":"L Bagateli","year":"2021 Sep 30 cited 2021 Oct 5","journal-title":"Vaccine."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1339-1349","DOI":"10.1080\/14760584.2021.1967147","article-title":"Determinants of parental hesitancy to vaccinate their children against COVID-19 in China.","volume":"20","author":"M Zhang","year":"2021 Aug 23 cited 2021 Oct 5","journal-title":"Expert Rev. Vaccines."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e050303","DOI":"10.1136\/bmjopen-2021-050303","article-title":"What is the extent of COVID-19 vaccine hesitancy in Bangladesh? A cross-sectional rapid national survey.","volume":"11","author":"M Ali","year":"2021 Aug 24 cited 2021 Aug 24","journal-title":"BMJ Open."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"87-94","DOI":"10.1016\/j.socscimed.2018.12.020","article-title":"\u201cYou don\u2019t trust a government vaccine\u201d: Narratives of institutional trust and influenza vaccination among African American and white adults.","volume":"221","author":"A Jamison","year":"2019 Jan cited 2021 Nov 4","journal-title":"Soc. Sci. 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We have amended our manuscript based on your directions. Please find the point-by-point solution to the problems.  \n<b>Abstract:<\/b>  We have amended the abstract according to your suggestion. The correction has been made in the method section. We replaced &lt; by below where appropriate. The result section has been rewritten. However, we can not add AOR and CI due to word restrictions of the abstract.  \n<b>Main text:<\/b> Introduction:  We replaced symbols with words where applicable. Please be assured that this manuscript is grammatical-error-free; however, we rechecked and made amendments where needed. We amended the justification of the study. The age of marriage in Bangladesh is 18 years and above, thus, we have taken data only from adult parents.  Methods: Study design  We exclude parents &lt;18 years. We clarified inclusion and exclusion criteria. We use the Bangla language, clearly mentioned in the method section. The sample size formula has been described clearly; please find the formula with appropriate references. This is a questionnaire consisting of one question. British Medical Journal has published data using this questionnaire in Bangladesh (Ali &amp; Hossain, 2021).  Questionnaire  Please find the questionnaire in the supplementary section. Funding information has been added; find the information at the upper end of the article.  Sampling technique  We clearly described that the list had been collected from the division's website.  Statistical analysis  Yes, we followed previously published studies when categorising the vaccine intention (Ali &amp; Hossain, 2021; Khubchandani et al., 2021). We used descriptive analysis for categorical variables. The final model has included significant variables found in the descriptive analysis. Find the information in the statistical analysis section.  Results  Our aim was not to compare the hesitancy considering division; rather, we compared the zones of Bangladesh. Future studies should compare the prevalence of COVID-19 vaccine hesitancy according to the divisions.&nbsp; We replaced the loved one with a family member. Thanks for the suggestion. To reduce the words, we refer a few to the table. We use perceived threat as the independent variable, which is one of our core findings. This variable has been used in previous studies as an independent variable. Symbol of Bangladeshi taka is well accepted any used previously by British Medical Journal. We kept the symbol. Mentioned. We used the variable as it is at the core of vaccine hesitancy. We discussed the implications in the discussion section. We have shown the diversity of religions in the study that clearly reflects the general Bangladeshi population. However, when we take this variable in regression, we combined Christian and Buddhists (total 21 samples). We corrected the error. Thank you for your meticulous observation.  Conclusion  We rewrote the conclusion section.   Finally, we would like to thank you again for your time and dedication when reviewing the paper. Your suggestion made the paper improve than before.  References: Ali, M., &amp; Hossain, A. (2021). What is the extent of COVID-19 vaccine hesitancy in Bangladesh? A cross-sectional rapid national survey. \n<i>BMJ Open<\/i>, \n<i>11<\/i>(8), e050303. https:\/\/doi.org\/10.1136\/bmjopen-2021-050303 Khubchandani, J., Sharma, S., Price, J. H., Wiblishauser, M. J., Sharma, M., &amp; Webb, F. J. (2021). COVID-19 Vaccination Hesitancy in the United States: A Rapid National Assessment. \n<i>Journal of Community Health<\/i>, 1\u20138. https:\/\/doi.org\/10.1007\/s10900-020-00958-x","URL":"https:\/\/f1000research.com\/articles\/11-90\/v2#referee-comment-7884","order":1,"name":"referee-comment-7884","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.80146.r121413, F. M. Moinuddin, Mayo Clinic Neuro-Informatics Laboratory, Mayo Clinic, Rochester, MN, USA, 09 Feb 2022, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/11-90\/v1#referee-response-121413","order":2,"name":"referee-response-121413","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Mohammad Ali<\/b>; \n<i>Posted: 27 Feb 2022<\/i>; Dear reviewer, thank you very much for your review and insight. We have revised our paper according to your suggestions. &nbsp;  We replaced 0.000 by &lt;0.001. In table 1, zero has been added before the decimal point. You are right; we get most data for children under 12. However, the vaccine is being approved for all the pediatric population (0-&lt;18 years). This study will be useful when the COVID-19 vaccine is approved for children under 12 years.","URL":"https:\/\/f1000research.com\/articles\/11-90\/v2#referee-comment-7885","order":3,"name":"referee-comment-7885","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.80146.r120978, Dr. Manzur Kader, Post doctoral researcher, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 11 Feb 2022, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/11-90\/v1#referee-response-120978","order":4,"name":"referee-response-120978","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Mohammad Ali<\/b>; \n<i>Posted: 27 Feb 2022<\/i>; Dear reviewer, thank you very much for your precise suggestions. We have revised our manuscript in light of your directions.  \n<b>Abstract:<\/b> Method  We relaced the word predictor by associated factors. Most of the studies used a web-based data collection method in the pandemic time. However, we use the in-person interviews (face-to-face) method to get high-quality data. The question was named as vaccine hesitancy questionnaire.  Result  &amp; 2. We rewrote the result section.  \n<b>Main text:<\/b> Introduction:  Data regarding parental vaccine hesitancy in low and middle-income countries were scarce; thus, we could not add more references. We amended the sentence. Example added.  Method:  We can not extract Cronbach's alfa value for a questionnaire consisting of only one. This questionnaire was used for a vaccine hesitancy study among adults in Bangladesh (Ali &amp; Hossain, 2021).  Result:  The symbol is well accepted and used by the British Medical Journal.  Discussion: &nbsp;  The statement has been added in the discussion section.    References: Ali, M., &amp; Hossain, A. (2021). What is the extent of COVID-19 vaccine hesitancy in Bangladesh? A cross-sectional rapid national survey. \n<i>BMJ Open<\/i>, \n<i>11<\/i>(8), e050303. https:\/\/doi.org\/10.1136\/bmjopen-2021-050303","URL":"https:\/\/f1000research.com\/articles\/11-90\/v2#referee-comment-7886","order":5,"name":"referee-comment-7886","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":6,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}