{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:09:37Z","timestamp":1772168977180,"version":"3.50.1"},"reference-count":6,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T00:00:00Z","timestamp":1454371200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Myeloid sarcoma results from the extramedullary homing and proliferation of immature myeloid precursors. We present the timeline, events and diagnostic pitfalls related to a 66 year-old male patient\u2019s case, admitted to the Hematology Clinic for pancytopenia, fever, weight loss and fatigue. The severe cytopenia and the few blasts observed in his blood smear indicated a bone marrow biopsy. The bone marrow showed hypercellularity and multilineage dysplasia with the presence of 15% myeloblasts. After the biopsy, he promptly developed paraplegia and nuclear magnetic resonance revealed an epidural tumour which was then resected.In the epidural tumour mass blast-like, round cells were observed with a complex immunophenotype, characterized by myeloperoxidase, CD117, CD15, CD99, leucocyte common antigen positivity and a high Ki-67 proliferation index. Considering the main differential diagnostic issues, the final diagnosis was stated as myelodysplastic syndrome-associated myeloid sarcoma. The prognosis was unfavourable, the bone marrow was quickly invaded by proliferating blast cells, and despite chemotherapy attempts, the patient died.<\/ns4:p>","DOI":"10.12688\/f1000research.7899.1","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T11:15:38Z","timestamp":1454411738000},"page":"128","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Case Report: Myelodysplastic syndrome- associated myeloid sarcoma: an unusual clinical presentation of a rare disease"],"prefix":"10.12688","volume":"5","author":[{"given":"Emoke","family":"Horvath","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smaranda","family":"Demian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elod","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2016,2,2]]},"reference":[{"key":"ref-1","first-page":"265-270","article-title":"Granulocytic sarcoma: a systematic review.","volume":"3","author":"A Yilmaz","year":"2013","journal-title":"Am J Blood Res."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"866.e7-866.e10","DOI":"10.1016\/j.wneu.2015.04.017","article-title":"Aggressive Myeloid Sarcoma Causing Recurrent Spinal Cord Compression.","volume":"84","author":"J Joseph","year":"2015","journal-title":"World 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.8503.r12783, Judit Csomor, 1st Department of Pathology and Experimental Cancer Research , Faculty of Medicine, Semmelweis University, Budapest, Hungary, 14 Mar 2016, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/5-128\/v1#referee-response-12783","order":0,"name":"referee-response-12783","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.8503.r12978, Erika Toth, Surgical and Molecular Tumour Pathology Centre, National Institute of Oncology, Budapest, Hungary, 22 Mar 2016, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/5-128\/v1#referee-response-12978","order":1,"name":"referee-response-12978","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this 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