{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:27:03Z","timestamp":1790177223379,"version":"4.1.0"},"reference-count":74,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T00:00:00Z","timestamp":1461801600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>T helper (Th) cells producing interleukin (IL)-17, IL-22, and tumor necrosis factor (TNF) form the key T cell population driving psoriasis pathogenesis. They orchestrate the inflammation in the skin that results in the proliferation of keratinocytes and endothelial cells. Besides Th17 cells, other immune cells that are capable of producing IL-17-associated cytokines participate in psoriatic inflammation. Recent advances in psoriasis research improved our understanding of the cellular and molecular players that are involved in Th17 pathology and inflammatory pathways in the skin. The inflammation-driving actions of TNF in psoriasis are already well known and antibodies against TNF are successful in the treatment of Th17-mediated psoriatic skin inflammation. A further key cytokine with potent IL-17-\/IL-22-promoting properties is IL-23. Therapeutics directly neutralizing IL-23 or IL-17 itself are now extending the therapeutic spectrum of antipsoriatic agents and further developments are on the way. The enormous progress in psoriasis research allows us to control this Th17-mediated inflammatory skin disease in many patients.<\/ns4:p>","DOI":"10.12688\/f1000research.7927.1","type":"journal-article","created":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T05:55:09Z","timestamp":1461822909000},"page":"770","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":113,"title":["Recent advances in understanding psoriasis"],"prefix":"10.12688","volume":"5","author":[{"given":"Franziska C.","family":"Eberle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Br\u00fcck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Holstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Hirahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran","family":"Ghoreschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2016,4,28]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"4","DOI":"10.12703\/P6-4","article-title":"Advances in treating psoriasis.","volume":"6","author":"K Belge","year":"2014","journal-title":"F1000Prime Rep."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"496-509","DOI":"10.1056\/NEJMra0804595","article-title":"Psoriasis.","volume":"361","author":"F Nestle","year":"2009","journal-title":"N Engl J Med."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"227-55","DOI":"10.1146\/annurev-immunol-032713-120225","article-title":"Immunology of psoriasis.","volume":"32","author":"M Lowes","year":"2014","journal-title":"Annu Rev Immunol."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"983-94","DOI":"10.1016\/S0140-6736(14)61909-7","article-title":"Psoriasis.","volume":"386","author":"W Boehncke","year":"2015","journal-title":"Lancet."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"232-48","DOI":"10.1111\/j.1365-2613.2009.00669.x","article-title":"Angiogenesis drives psoriasis pathogenesis.","volume":"90","author":"R Heidenreich","year":"2009","journal-title":"Int J Exp Pathol."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"3-10","DOI":"10.1007\/s00281-015-0545-x","article-title":"Cutaneous immunology: basics and new concepts.","volume":"38","author":"A Yazdi","year":"2016","journal-title":"Semin Immunopathol."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"623-8","DOI":"10.1111\/1523-1747.ep12261462","article-title":"Cell proliferation in normal epidermis.","volume":"82","author":"G Weinstein","year":"1984","journal-title":"J Invest Dermatol."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"369-75","DOI":"10.1038\/nature03963","article-title":"Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins.","volume":"437","author":"R Zenz","year":"2005","journal-title":"Nature."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"43-9","DOI":"10.1038\/nm1162","article-title":"Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model.","volume":"11","author":"S Sano","year":"2005","journal-title":"Nat Med."},{"key":"ref-10","doi-asserted-by":"crossref","first-page":"53-8","DOI":"10.1111\/1523-1747.ep12523566","article-title":"Identification of C5ades arg and an anionic neutrophil-activating peptide (ANAP) in psoriatic scales.","volume":"87","author":"J Schr\u00f6der","year":"1986","journal-title":"J Invest Dermatol."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"2105-17","DOI":"10.1084\/jem.20130291","article-title":"Epidermal IL-15R\u03b1 acts as an endogenous antagonist of psoriasiform inflammation in mouse and man.","volume":"210","author":"G Bouchaud","year":"2013","journal-title":"J Exp Med."},{"key":"ref-12","doi-asserted-by":"publisher","first-page":"388-400","DOI":"10.1016\/j.immuni.2012.01.018","article-title":"Inflammasome activators induce interleukin-1\u03b1 secretion via distinct pathways with differential requirement for the protease function of caspase-1.","volume":"36","author":"O Gross","year":"2012","journal-title":"Immunity."},{"key":"ref-13","doi-asserted-by":"publisher","first-page":"82ra38","DOI":"10.1126\/scitranslmed.3002001","article-title":"Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions.","volume":"3","author":"Y Dombrowski","year":"2011","journal-title":"Sci Transl Med."},{"key":"ref-14","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1136\/bmj.300.6729.908","article-title":"Clearance of severe psoriasis after allogenic bone marrow transplantation.","volume":"300","author":"D Eedy","year":"1990","journal-title":"BMJ."},{"key":"ref-15","doi-asserted-by":"publisher","first-page":"130-2","DOI":"10.1046\/j.1365-2133.1997.17821869.x","article-title":"Development of psoriasis after syngeneic bone marrow transplant from psoriatic donor: further evidence for adoptive autoimmunity.","volume":"137","author":"J Snowden","year":"1997","journal-title":"Br J Dermatol."},{"key":"ref-16","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1056\/NEJM197909063011015","article-title":"Cyclosporin A for psoriasis.","volume":"301","author":"W Mueller","year":"1979","journal-title":"N Engl J Med."},{"key":"ref-17","doi-asserted-by":"publisher","first-page":"981-2","DOI":"10.1016\/S0140-6736(84)91194-2","article-title":"Cyclosporin for psoriasis.","volume":"2","author":"J Harper","year":"1984","journal-title":"Lancet."},{"key":"ref-18","doi-asserted-by":"publisher","first-page":"5392-402","DOI":"10.4049\/jimmunol.0903520","article-title":"Ezrin, maspin, peroxiredoxin 2, and heat shock protein 27: potential targets of a streptococcal-induced autoimmune response in psoriasis.","volume":"184","author":"P Besgen","year":"2010","journal-title":"J Immunol."},{"key":"ref-19","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6621","article-title":"The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis.","volume":"5","author":"R Lande","year":"2014","journal-title":"Nat Commun."},{"key":"ref-20","doi-asserted-by":"publisher","first-page":"2203-12","DOI":"10.1084\/jem.20151093","article-title":"Melanocyte antigen triggers autoimmunity in human psoriasis.","volume":"212","author":"A Arakawa","year":"2015","journal-title":"J Exp Med."},{"key":"ref-21","doi-asserted-by":"publisher","first-page":"967-71","DOI":"10.1038\/nature09447","article-title":"Generation of pathogenic TH17 cells in the absence of TGF-\u03b2 signalling.","volume":"467","author":"K Ghoreschi","year":"2010","journal-title":"Nature."},{"key":"ref-22","doi-asserted-by":"publisher","first-page":"425-34","DOI":"10.1016\/j.cytogfr.2010.10.006","article-title":"Signal transduction pathways and transcriptional regulation in Th17 cell differentiation.","volume":"21","author":"K Hirahara","year":"2010","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref-23","doi-asserted-by":"publisher","first-page":"688-97","DOI":"10.1038\/nm.3883","article-title":"The emerging role of resident memory T cells in protective immunity and inflammatory disease.","volume":"21","author":"C Park","year":"2015","journal-title":"Nat Med."},{"key":"ref-24","doi-asserted-by":"publisher","first-page":"93-8","DOI":"10.1126\/science.1257530","article-title":"T cell memory. A local macrophage chemokine network sustains protective tissue-resident memory CD4 T cells.","volume":"346","author":"N Iijima","year":"2014","journal-title":"Science."},{"key":"ref-25","doi-asserted-by":"publisher","first-page":"647-53","DOI":"10.1038\/nm.3860","article-title":"Common clonal origin of central and resident memory T cells following skin immunization.","volume":"21","author":"O Gaide","year":"2015","journal-title":"Nat Med."},{"key":"ref-26","doi-asserted-by":"publisher","first-page":"279ra39","DOI":"10.1126\/scitranslmed.3010302","article-title":"Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells.","volume":"7","author":"R Watanabe","year":"2015","journal-title":"Sci Transl Med."},{"key":"ref-27","doi-asserted-by":"publisher","first-page":"3111-20","DOI":"10.4049\/jimmunol.1302313","article-title":"Epidermal Th22 and Tc17 cells form a localized disease memory in clinically healed psoriasis.","volume":"192","author":"S Cheuk","year":"2014","journal-title":"J Immunol."},{"key":"ref-28","doi-asserted-by":"publisher","first-page":"219ra8","DOI":"10.1126\/scitranslmed.3007828","article-title":"Human TH9 cells are skin-tropic and have autocrine and paracrine proinflammatory capacity.","volume":"6","author":"C Schlapbach","year":"2014","journal-title":"Sci Transl Med."},{"key":"ref-29","doi-asserted-by":"publisher","first-page":"792-801","DOI":"10.1111\/j.1365-2133.2011.10430.x","article-title":"Sun exposure rapidly reduces plasmacytoid dendritic cells and inflammatory dermal dendritic cells in psoriatic skin.","volume":"165","author":"I Heier","year":"2011","journal-title":"Br J Dermatol."},{"key":"ref-30","doi-asserted-by":"publisher","first-page":"302-8","DOI":"10.1038\/jid.2008.225","article-title":"Resident and \"inflammatory\" dendritic cells in human skin.","volume":"129","author":"L Zaba","year":"2009","journal-title":"J Invest Dermatol."},{"key":"ref-31","doi-asserted-by":"publisher","first-page":"1261-1268.e9","DOI":"10.1016\/j.jaci.2010.03.018","article-title":"Identification of TNF-related apoptosis-inducing ligand and other molecules that distinguish inflammatory from resident dendritic cells in patients with psoriasis.","volume":"125","author":"L Zaba","year":"2010","journal-title":"J Allergy Clin Immunol."},{"key":"ref-32","doi-asserted-by":"publisher","first-page":"135-43","DOI":"10.1084\/jem.20050500","article-title":"Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production.","volume":"202","author":"F Nestle","year":"2005","journal-title":"J Exp Med."},{"key":"ref-33","doi-asserted-by":"publisher","first-page":"564-9","DOI":"10.1038\/nature06116","article-title":"Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide.","volume":"449","author":"R Lande","year":"2007","journal-title":"Nature."},{"key":"ref-34","doi-asserted-by":"publisher","first-page":"1983-94","DOI":"10.1084\/jem.20090480","article-title":"Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8.","volume":"206","author":"D Ganguly","year":"2009","journal-title":"J Exp Med."},{"key":"ref-35","doi-asserted-by":"publisher","first-page":"970-9","DOI":"10.1038\/ni.3211","article-title":"TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26.","volume":"16","author":"S Meller","year":"2015","journal-title":"Nat Immunol."},{"key":"ref-36","doi-asserted-by":"publisher","first-page":"289-301","DOI":"10.1016\/S1074-7613(02)00393-X","article-title":"6-Sulfo LacNAc, a novel carbohydrate modification of PSGL-1, defines an inflammatory type of human dendritic cells.","volume":"17","author":"K Sch\u00e4kel","year":"2002","journal-title":"Immunity."},{"key":"ref-37","doi-asserted-by":"publisher","first-page":"535-40","DOI":"10.1111\/exd.12190","article-title":"Reduction of inflammatory slan (6-sulfo LacNAc) dendritic cells in psoriatic skin of patients treated with etanercept.","volume":"22","author":"C G\u00fcnther","year":"2013","journal-title":"Exp Dermatol."},{"key":"ref-38","doi-asserted-by":"publisher","first-page":"1092-102","DOI":"10.1111\/j.1365-2133.2008.08769.x","article-title":"Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways.","volume":"159","author":"K Nograles","year":"2008","journal-title":"Br J Dermatol."},{"key":"ref-39","doi-asserted-by":"publisher","first-page":"121-55","DOI":"10.1146\/annurev-immunol-032713-120216","article-title":"\u03b3\u03b4 T cells: first line of defense and beyond.","volume":"32","author":"Y Chien","year":"2014","journal-title":"Annu Rev Immunol."},{"key":"ref-40","doi-asserted-by":"publisher","first-page":"293-301","DOI":"10.1038\/nature14189","article-title":"The biology of innate lymphoid cells.","volume":"517","author":"D Artis","year":"2015","journal-title":"Nature."},{"key":"ref-41","doi-asserted-by":"publisher","first-page":"804-6","DOI":"10.1111\/exd.12541","article-title":"The plot thickens while the scope broadens: a holistic view on IL-17 in psoriasis and other inflammatory disorders.","volume":"23","author":"M Sch\u00f6n","year":"2014","journal-title":"Exp Dermatol."},{"key":"ref-42","doi-asserted-by":"publisher","first-page":"23-49","DOI":"10.1111\/imr.12208","article-title":"Transcriptional and epigenetic networks of helper T and innate lymphoid cells.","volume":"261","author":"H Shih","year":"2014","journal-title":"Immunol Rev."},{"key":"ref-43","doi-asserted-by":"publisher","first-page":"415-28","DOI":"10.1038\/nri3855","article-title":"Transcriptional regulation of innate lymphoid cell fate.","volume":"15","author":"N Serafini","year":"2015","journal-title":"Nat Rev Immunol."},{"key":"ref-44","doi-asserted-by":"publisher","first-page":"35-41","DOI":"10.1084\/jem.20072713","article-title":"Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22.","volume":"206","author":"H Takatori","year":"2009","journal-title":"J Exp Med."},{"key":"ref-45","doi-asserted-by":"publisher","first-page":"2331-8","DOI":"10.1084\/jem.20122097","article-title":"Distinct requirements for T-bet in gut innate lymphoid cells.","volume":"209","author":"G Scium\u00e9","year":"2012","journal-title":"J Exp Med."},{"key":"ref-46","doi-asserted-by":"publisher","first-page":"722-5","DOI":"10.1038\/nature07537","article-title":"A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity.","volume":"457","author":"M Cella","year":"2009","journal-title":"Nature."},{"key":"ref-47","doi-asserted-by":"publisher","first-page":"984-91","DOI":"10.1038\/jid.2013.477","article-title":"Characterization of innate lymphoid cells in human skin and blood demonstrates increase of NKp44+ ILC3 in psoriasis.","volume":"134","author":"F Villanova","year":"2014","journal-title":"J Invest Dermatol."},{"key":"ref-48","doi-asserted-by":"publisher","first-page":"609-16","DOI":"10.1111\/bjd.12658","article-title":"Increased number and frequency of group 3 innate lymphoid cells in nonlesional psoriatic skin.","volume":"170","author":"B Dyring-Andersen","year":"2014","journal-title":"Br J Dermatol."},{"key":"ref-49","doi-asserted-by":"publisher","first-page":"6091-5","DOI":"10.4049\/jimmunol.1100427","article-title":"Cutting edge: Identification of a motile IL-17-producing gammadelta T cell population in the dermis.","volume":"186","author":"E Gray","year":"2011","journal-title":"J Immunol."},{"key":"ref-50","doi-asserted-by":"publisher","first-page":"2252-6","DOI":"10.1172\/JCI61862","article-title":"Ror\u03b3t+ innate lymphocytes and \u03b3\u03b4 T cells initiate psoriasiform plaque formation in mice.","volume":"122","author":"S Pantelyushin","year":"2012","journal-title":"J Clin Invest."},{"key":"ref-51","doi-asserted-by":"publisher","first-page":"8046-51","DOI":"10.1073\/pnas.1508990112","article-title":"Inflammation induces dermal V\u03b3 4+ \u03b3\u03b4T17 memory-like cells that travel to distant skin and accelerate secondary IL-17-driven responses.","volume":"112","author":"F Ram\u00edrez-Valle","year":"2015","journal-title":"Proc Natl Acad Sci U S A."},{"key":"ref-52","doi-asserted-by":"publisher","first-page":"3022-33","DOI":"10.1002\/eji.201545883","article-title":"Dermal IL-17-producing \u03b3\u03b4 T cells establish long-lived memory in the skin.","volume":"45","author":"T Hartwig","year":"2015","journal-title":"Eur J Immunol."},{"key":"ref-53","doi-asserted-by":"publisher","first-page":"596-610","DOI":"10.1016\/j.immuni.2011.08.001","article-title":"Pivotal role of dermal IL-17-producing \u03b3\u03b4 T cells in skin inflammation.","volume":"35","author":"Y Cai","year":"2011","journal-title":"Immunity."},{"key":"ref-54","doi-asserted-by":"publisher","first-page":"351-9.e1","DOI":"10.1016\/j.jaci.2015.01.033","article-title":"Human mast cells are major IL-22 producers in patients with psoriasis and atopic dermatitis.","volume":"136","author":"S Mashiko","year":"2015","journal-title":"J Allergy Clin Immunol."},{"key":"ref-55","doi-asserted-by":"publisher","first-page":"2291-303","DOI":"10.1084\/jem.20100977","article-title":"Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells.","volume":"208","author":"K Ghoreschi","year":"2011","journal-title":"J Exp Med."},{"key":"ref-56","doi-asserted-by":"publisher","first-page":"842-55","DOI":"10.1111\/j.1476-5381.2009.00559.x","article-title":"Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis.","volume":"159","author":"P Schafer","year":"2010","journal-title":"Br J Pharmacol."},{"key":"ref-57","doi-asserted-by":"publisher","first-page":"3530-9","DOI":"10.4049\/jimmunol.1300556","article-title":"Sulforaphane protects from T cell-mediated autoimmune disease by inhibition of IL-23 and IL-12 in dendritic cells.","volume":"192","author":"J Geisel","year":"2014","journal-title":"J Immunol."},{"key":"ref-58","doi-asserted-by":"publisher","first-page":"2216-23","DOI":"10.4049\/jimmunol.1402989","article-title":"Cholesterol Modification of p40-Specific Small Interfering RNA Enables Therapeutic Targeting of Dendritic Cells.","volume":"195","author":"J Br\u00fcck","year":"2015","journal-title":"J Immunol."},{"key":"ref-59","doi-asserted-by":"publisher","first-page":"356-60","DOI":"10.1038\/ni.1701","article-title":"Selectivity and therapeutic inhibition of kinases: to be or not to be?","volume":"10","author":"K Ghoreschi","year":"2009","journal-title":"Nat Immunol."},{"key":"ref-60","doi-asserted-by":"publisher","first-page":"4234-43","DOI":"10.4049\/jimmunol.1003668","article-title":"Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550).","volume":"186","author":"K Ghoreschi","year":"2011","journal-title":"J Immunol."},{"key":"ref-61","doi-asserted-by":"publisher","first-page":"7-11","DOI":"10.1111\/exd.12265","article-title":"Jakpot! New small molecules in autoimmune and inflammatory diseases.","volume":"23","author":"K Ghoreschi","year":"2014","journal-title":"Exp Dermatol."},{"key":"ref-62","doi-asserted-by":"publisher","first-page":"1184-1193.e8","DOI":"10.1016\/j.jaci.2013.05.036","article-title":"Infliximab induces downregulation of the IL-12\/IL-23 axis in 6-sulfo-LacNac (slan)+ dendritic cells and macrophages.","volume":"132","author":"P Brunner","year":"2013","journal-title":"J Allergy Clin Immunol."},{"key":"ref-63","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12927","article-title":"The single-chain anti-TNF-\u03b1 antibody DLX105 induces clinical and biomarker responses upon local administration in patients with chronic plaque-type psoriasis.","author":"A Tsianakas","year":"2016","journal-title":"Exp Dermatol."},{"key":"ref-64","doi-asserted-by":"publisher","first-page":"222-6","DOI":"10.1038\/nature14175","article-title":"Clinical improvement in psoriasis with specific targeting of interleukin-23.","volume":"521","author":"T Kopp","year":"2015","journal-title":"Nature."},{"key":"ref-65","doi-asserted-by":"publisher","first-page":"52ra72","DOI":"10.1126\/scitranslmed.3001107","article-title":"Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis.","volume":"2","author":"W Hueber","year":"2010","journal-title":"Sci Transl Med."},{"key":"ref-66","doi-asserted-by":"publisher","first-page":"541-51","DOI":"10.1016\/S0140-6736(15)60125-8","article-title":"Comparison of ixekizumab with etanercept or placebo in moderate-to-severe psoriasis (UNCOVER-2 and UNCOVER-3): results from two phase 3 randomised trials.","volume":"386","author":"C Griffiths","year":"2015","journal-title":"Lancet."},{"key":"ref-67","doi-asserted-by":"publisher","first-page":"40-6","DOI":"10.1038\/nm804","article-title":"Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease.","volume":"9","author":"K Ghoreschi","year":"2003","journal-title":"Nat Med."},{"key":"ref-68","doi-asserted-by":"publisher","first-page":"2163-8","DOI":"10.1073\/pnas.1416922112","article-title":"IL-4 abrogates TH17 cell-mediated inflammation by selective silencing of IL-23 in antigen-presenting cells.","volume":"112","author":"E Guenova","year":"2015","journal-title":"Proc Natl Acad Sci U S A."},{"key":"ref-69","doi-asserted-by":"publisher","first-page":"2757-67","DOI":"10.1038\/jid.2014.308","article-title":"IL-19 is a component of the pathogenetic IL-23\/IL-17 cascade in psoriasis.","volume":"134","author":"E Witte","year":"2014","journal-title":"J Invest Dermatol."},{"key":"ref-70","doi-asserted-by":"publisher","first-page":"244ra90","DOI":"10.1126\/scitranslmed.3008946","article-title":"Intraindividual genome expression analysis reveals a specific molecular signature of psoriasis and eczema.","volume":"6","author":"M Quaranta","year":"2014","journal-title":"Sci Transl Med."},{"key":"ref-71","doi-asserted-by":"publisher","first-page":"1171-81","DOI":"10.1016\/j.immuni.2013.11.011","article-title":"S100A8-S100A9 protein complex mediates psoriasis by regulating the expression of complement factor C3.","volume":"39","author":"H Schonthaler","year":"2013","journal-title":"Immunity."},{"key":"ref-72","doi-asserted-by":"publisher","first-page":"620-8","DOI":"10.1056\/NEJMoa1013068","article-title":"Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis.","volume":"365","author":"S Marrakchi","year":"2011","journal-title":"N Engl J Med."},{"key":"ref-73","doi-asserted-by":"publisher","first-page":"2964-70","DOI":"10.1038\/jid.2015.288","article-title":"Activating CARD14 Mutations Are Associated with Generalized Pustular Psoriasis but Rarely Account for Familial Recurrence in Psoriasis Vulgaris.","volume":"135","author":"D Berki","year":"2015","journal-title":"J Invest Dermatol."},{"key":"ref-74","doi-asserted-by":"publisher","first-page":"202-4","DOI":"10.1111\/bjd.12548","article-title":"Successful therapy with anakinra in a patient with generalized pustular psoriasis carrying IL36RN mutations.","volume":"170","author":"U H\u00fcffmeier","year":"2014","journal-title":"Br J Dermatol."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/5-770\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/5-770\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/5-770\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T10:32:06Z","timestamp":1553250726000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/5-770\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,28]]},"references-count":74,"URL":"https:\/\/doi.org\/10.12688\/f1000research.7927.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.8534.r13626","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.8534.r13627","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.8534.r13627","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.8534.r13626","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,28]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/5-770\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.8534.r13626, Thomas Herzinger, Department of Dermatology and Allergy, Ludwig Maximilian University, Munich, Germany, 28 Apr 2016, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/5-770\/v1#referee-response-13626","order":0,"name":"referee-response-13626","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.8534.r13627, Mario Fabri, Department of Dermatology and Venereology, University of Cologne, Cologne, Germany, 28 Apr 2016, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/5-770\/v1#referee-response-13627","order":1,"name":"referee-response-13627","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This work was supported by the Deutsche Forschungsgemeinschaft (DFG) Sonderforschungsbereich (SFB) 685 (to Kamran Ghoreschi) and SFB TR-156 (to Franziska C. Eberle and Kamran Ghoreschi). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}