{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:32:16Z","timestamp":1791484336374,"version":"4.3.4"},"reference-count":142,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T00:00:00Z","timestamp":1460937600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>The child with recent onset of tics is a common patient in a pediatrics or child neurology practice. If the child\u2019s first tic was less than a year in the past, the diagnosis is usually Provisional Tic Disorder (PTD). Published reviews by experts reveal substantial consensus on prognosis in this situation: the tics will almost always disappear in a few months, having remained mild while they lasted. Surprisingly, however, the sparse existing data may not support these opinions.<\/ns4:p>\n                  <ns4:p>PTD may have just as much importance for science as for clinical care. It provides an opportunity to prospectively observe the spontaneous remission of tics. Such prospective studies may aid identification of genes or biomarkers specifically associated with remission rather than onset of tics. A better understanding of tic remission may also suggest novel treatment strategies for Tourette syndrome, or may lead to secondary prevention of tic disorders.<\/ns4:p>\n                  <ns4:p>This review summarizes the limited existing data on the epidemiology, phenomenology, and outcome of PTD, highlights areas in which prospective study is sorely needed, and proposes that tic disorders may completely remit much less often than is generally believed.<\/ns4:p>","DOI":"10.12688\/f1000research.8428.1","type":"journal-article","created":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T10:10:06Z","timestamp":1460974206000},"page":"696","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":65,"title":["Provisional Tic Disorder: What to tell parents when their child first starts ticcing"],"prefix":"10.12688","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6921-9567","authenticated-orcid":false,"given":"Kevin J","family":"Black","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth Rose","family":"Black","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deanna J.","family":"Greene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley L.","family":"Schlaggar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2016,4,18]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"231-242","DOI":"10.1016\/j.spen.2006.09.004","article-title":"Tic disorders in childhood.","volume":"13","author":"J Dooley","year":"2006","journal-title":"Semin Pediatr Neurol."},{"key":"ref-2","doi-asserted-by":"crossref","first-page":"35-40","DOI":"10.1016\/S1071-9091(02)00007-4","article-title":"Tics and Tourette's syndrome in childhood.","volume":"10","author":"S Kuperman","year":"2003","journal-title":"Semin Pediatr Neurol."},{"key":"ref-3","first-page":"569-582","article-title":"Tic disorders.","author":"M Bloch","year":"2007"},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"223-233","DOI":"10.1542\/pir.31-6-223","article-title":"Movement disorders I: tics and stereotypies.","volume":"31","author":"S Zinner","year":"2010","journal-title":"Pediatr Rev."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"171-174","DOI":"10.1016\/j.jaapos.2003.10.007","article-title":"Tic disorders in children with frequent eye blinking.","volume":"8","author":"H Jung","year":"2004","journal-title":"J AAPOS."},{"key":"ref-6","doi-asserted-by":"crossref","first-page":"209-216","DOI":"10.1097\/00004703-198212000-00007","article-title":"Movement disorders in children: Tourette syndrome.","volume":"3","author":"G Golden","year":"1982","journal-title":"J Dev Behav Pediatr."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"519-530","DOI":"10.1016\/S0022-3956(97)00028-9","article-title":"Rates for tic disorders and obsessive compulsive symptomatology in families of children and adolescents with Gilles de la Tourette syndrome.","volume":"31","author":"J Hebebrand","year":"1997","journal-title":"J Psychiatr Res."},{"key":"ref-8","first-page":"2859-2865","article-title":"[Tic disorders].","volume":"51","author":"S Miyamoto","year":"1993","journal-title":"Nihon Rinsho."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"291-298","DOI":"10.1016\/S0733-8619(05)70313-3","article-title":"The course and prognosis of Tourette syndrome.","volume":"15","author":"R Bruun","year":"1997","journal-title":"Neurol Clin."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"1145-1150","DOI":"10.1001\/archneur.1994.00540230083017","article-title":"Hypothesis II: Tourette's syndrome is part of a clinical spectrum that includes normal brain development.","volume":"51","author":"R Kurlan","year":"1994","journal-title":"Arch Neurol."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"145-148","DOI":"10.1002\/ana.410040208","article-title":"Tics and Tourette's: a continuum of symptoms?","volume":"4","author":"G Golden","year":"1978","journal-title":"Ann Neurol."},{"key":"ref-12","doi-asserted-by":"publisher","article-title":"Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition","year":"2013","DOI":"10.1176\/appi.books.9780890425596"},{"key":"ref-13","doi-asserted-by":"publisher","first-page":"646-651","DOI":"10.1016\/j.arcped.2014.03.017","article-title":"[From tic disorders to Tourette syndrome: current data, comorbidities, and therapeutic approach in children].","volume":"21","author":"P Fourneret","year":"2014","journal-title":"Arch Pediatr."},{"key":"ref-14","first-page":"240-248","article-title":"Public health significance of tic disorders in children and adolescents.","volume":"96","author":"L Scahill","year":"2005","journal-title":"Adv Neurol."},{"key":"ref-15","first-page":"97-153","article-title":"Unvoluntary motor behaviors","author":"D Martino","year":"2016"},{"key":"ref-16","article-title":"Gilles de la Tourette Syndrome, 2nd ed.","author":"A Shapiro","year":"1988"},{"key":"ref-17","doi-asserted-by":"publisher","first-page":"1538-1549","DOI":"10.1002\/mds.23088","article-title":"Definition and classification of hyperkinetic movements in childhood.","volume":"25","author":"T Sanger","year":"2010","journal-title":"Mov Disord."},{"key":"ref-18","doi-asserted-by":"publisher","first-page":"231-236","DOI":"10.1016\/B978-0-12-374105-9.00385-3","article-title":"Tics","author":"K Black","year":"2010"},{"key":"ref-19","doi-asserted-by":"publisher","first-page":"2005-2011","DOI":"10.1007\/BF01720562","article-title":"\u00dcber den Tic im Kindesalter [On tics in childhood].","volume":"9","author":"C Boenheim","year":"1930","journal-title":"Klinische Wochenschrift."},{"key":"ref-20","article-title":"Tourette's syndrome -- tics, obsessions, compulsions: Developmental psychopathology and clinical care.","author":"J Leckman","year":"1999"},{"key":"ref-21","doi-asserted-by":"crossref","DOI":"10.1093\/med\/9780199796267.001.0001","article-title":"Tourette Syndrome.","author":"D Martino","year":"2013"},{"key":"ref-22","doi-asserted-by":"crossref","first-page":"14-19","DOI":"10.1542\/peds.102.1.14","article-title":"Course of tic severity in Tourette syndrome: the first two decades.","volume":"102","author":"J Leckman","year":"1998","journal-title":"Pediatrics."},{"key":"ref-23","doi-asserted-by":"publisher","first-page":"39-51","DOI":"10.1542\/pir.24-2-39","article-title":"Movement disorders in children.","volume":"24","author":"B Schlaggar","year":"2003","journal-title":"Pediatr Rev."},{"key":"ref-24","doi-asserted-by":"publisher","first-page":"600-610","DOI":"10.1002\/da.20711","article-title":"Tic disorders: some key issues for DSM-V.","volume":"27","author":"J Walkup","year":"2010","journal-title":"Depress Anxiety."},{"key":"ref-25","doi-asserted-by":"publisher","DOI":"10.7916\/D8445K68","article-title":"Review of prevalence studies of tic disorders: methodological caveats.","volume":"2","author":"E Cubo","year":"2012","journal-title":"Tremor Other Hyperkinet Mov (N Y)."},{"key":"ref-26","doi-asserted-by":"publisher","first-page":"473-486","DOI":"10.1016\/j.jpsychores.2008.03.007","article-title":"The prevalence and epidemiology of Gilles de la Tourette syndrome. Part 2: tentative explanations for differing prevalence figures in GTS, including the possible effects of psychopathology, aetiology, cultural differences, and differing phenotypes.","volume":"65","author":"M Robertson","year":"2008","journal-title":"J Psychosom Res."},{"key":"ref-27","doi-asserted-by":"publisher","first-page":"461-472","DOI":"10.1016\/j.jpsychores.2008.03.006","article-title":"The prevalence and epidemiology of Gilles de la Tourette syndrome. Part 1: the epidemiological and prevalence studies.","volume":"65","author":"M Robertson","year":"2008","journal-title":"J Psychosom Res."},{"key":"ref-28","doi-asserted-by":"publisher","first-page":"475-483","DOI":"10.1016\/j.jpsychores.2009.07.010","article-title":"The international prevalence, epidemiology, and clinical phenomenology of Tourette syndrome: a cross-cultural perspective.","volume":"67","author":"M Robertson","year":"2009","journal-title":"J Psychosom Res."},{"key":"ref-29","doi-asserted-by":"publisher","first-page":"221-228","DOI":"10.1002\/mds.26089","article-title":"Population prevalence of Tourette syndrome: a systematic review and meta-analysis.","volume":"30","author":"J Scharf","year":"2015","journal-title":"Mov Disord."},{"key":"ref-30","doi-asserted-by":"publisher","first-page":"77-90","DOI":"10.1016\/j.pediatrneurol.2012.05.002","article-title":"Prevalence of tic disorders: a systematic review and meta-analysis.","volume":"47","author":"T Knight","year":"2012","journal-title":"Pediatr Neurol."},{"key":"ref-31","doi-asserted-by":"crossref","first-page":"331-336","DOI":"10.1542\/peds.110.2.331","article-title":"Tics and problem behaviors in schoolchildren: prevalence, characterization, and associations.","volume":"110","author":"L Snider","year":"2002","journal-title":"Pediatrics."},{"key":"ref-32","doi-asserted-by":"publisher","first-page":"171-178","DOI":"10.1007\/s00787-007-0651-y","article-title":"Prevalence of tic disorders among schoolchildren in Warsaw, Poland.","volume":"17","author":"P Stefanoff","year":"2008","journal-title":"Eur Child Adolesc Psychiatry."},{"key":"ref-33","doi-asserted-by":"publisher","first-page":"330-338","DOI":"10.1111\/j.1469-8749.2002.tb00820.x","article-title":"Tics and psychiatric comorbidity in children and adolescents.","volume":"44","author":"K Gadow","year":"2002","journal-title":"Dev Med Child Neurol."},{"key":"ref-34","doi-asserted-by":"publisher","first-page":"315-319","DOI":"10.1111\/j.1469-8749.2003.tb00402.x","article-title":"Prevalence of tic disorders and Tourette syndrome in a Swedish school population.","volume":"45","author":"N Khalifa","year":"2003","journal-title":"Dev Med Child Neurol."},{"key":"ref-35","doi-asserted-by":"publisher","first-page":"734-738","DOI":"10.1001\/archpsyc.1993.01820210068008","article-title":"An epidemiologic study of Gilles de la Tourette's syndrome in Israel.","volume":"50","author":"A Apter","year":"1993","journal-title":"Arch Gen Psychiatry."},{"key":"ref-36","first-page":"463-469","article-title":"An epidemiologic study of Tourette's syndrome in a single school district.","volume":"51","author":"D Comings","year":"1990","journal-title":"J Clin Psychiatry."},{"key":"ref-37","doi-asserted-by":"publisher","first-page":"699-702","DOI":"10.1212\/WNL.44.4.699","article-title":"Tourette's syndrome in a special education population: a pilot 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Baron-Cohen","year":"1999","journal-title":"Psychol Med."},{"key":"ref-41","doi-asserted-by":"publisher","first-page":"649-655","DOI":"10.1111\/j.1440-1819.1990.tb01641.x","article-title":"An epidemiological study of tics.","volume":"44","author":"F Nomoto","year":"1990","journal-title":"Jpn J Psychiatry Neurol."},{"key":"ref-42","doi-asserted-by":"publisher","first-page":"398-400","DOI":"10.1016\/j.ejpn.2007.10.006","article-title":"Factors influencing diagnosis delay in children with Tourette syndrome.","volume":"12","author":"Y Shilon","year":"2008","journal-title":"Eur J Paediatr Neurol."},{"key":"ref-42a","doi-asserted-by":"publisher","first-page":"292-296","DOI":"10.1111\/j.1469-8749.1998.tb15379.x","article-title":"The prevalence of Tourette syndrome in a mainstream school population.","volume":"40","author":"A Mason","year":"1998","journal-title":"Dev Med Child Neurol."},{"key":"ref-43","doi-asserted-by":"publisher","first-page":"579-593","DOI":"10.1007\/BF02168939","article-title":"Observations and ratings of tics in school settings.","volume":"22","author":"E Nolan","year":"1994","journal-title":"J Abnorm Child Psychol."},{"key":"ref-44","doi-asserted-by":"publisher","first-page":"414-420","DOI":"10.1212\/WNL.59.3.414","article-title":"The behavioral spectrum of tic disorders: a community-based study.","volume":"59","author":"R Kurlan","year":"2002","journal-title":"Neurology."},{"key":"ref-45","doi-asserted-by":"publisher","first-page":"1035-1039","DOI":"10.1111\/1469-7610.00802","article-title":"The prevalence of Tourette syndrome in 13-14-year-olds in mainstream schools.","volume":"42","author":"H Hornsey","year":"2001","journal-title":"J Child Psychol Psychiatry."},{"key":"ref-46","doi-asserted-by":"publisher","first-page":"2106-2109","DOI":"10.1002\/mds.21117","article-title":"Prevalence of tic disorder in two schools in the Basque country: Results and methodological caveats.","volume":"21","author":"G Linazasoro","year":"2006","journal-title":"Mov Disord."},{"key":"ref-47","doi-asserted-by":"crossref","first-page":"1608-1614","DOI":"10.1111\/j.1651-2227.2005.tb01837.x","article-title":"Tourette syndrome and other tic disorders in a total population of children: clinical assessment and background.","volume":"94","author":"N Khalifa","year":"2005","journal-title":"Acta Paediatr."},{"key":"ref-48","doi-asserted-by":"publisher","first-page":"842-847","DOI":"10.1001\/archpsyc.56.9.842","article-title":"The 4-year course of tic disorders in boys with attention-deficit\/hyperactivity disorder.","volume":"56","author":"T Spencer","year":"1999","journal-title":"Arch Gen Psychiatry."},{"key":"ref-49","doi-asserted-by":"publisher","first-page":"944-951","DOI":"10.1097\/00004583-199908000-00009","article-title":"Do typical clinical doses of methylphenidate cause tics in children treated for attention-deficit hyperactivity disorder?","volume":"38","author":"S Law","year":"1999","journal-title":"J Am Acad Child Adolesc Psychiatry."},{"key":"ref-50","doi-asserted-by":"publisher","first-page":"377-385","DOI":"10.1097\/00004583-199403000-00012","article-title":"A prospective longitudinal study of Gilles de la Tourette's syndrome.","volume":"33","author":"A Carter","year":"1994","journal-title":"J Am Acad Child Adolesc Psychiatry."},{"key":"ref-51","doi-asserted-by":"publisher","first-page":"105-111","DOI":"10.1002\/ajmg.b.20065","article-title":"Children at familial risk for Tourette's disorder: Child and parent diagnoses.","volume":"121B","author":"W McMahon","year":"2003","journal-title":"Am J Med Genet B Neuropsychiatr Genet."},{"key":"ref-52","first-page":"824-832","article-title":"Semiology, nosology and criteria for tic disorders.","volume":"142","author":"E Shapiro","year":"1986","journal-title":"Rev Neurol (Paris)."},{"key":"ref-53","doi-asserted-by":"publisher","first-page":"738-743","DOI":"10.1136\/jnnp.68.6.738","article-title":"Adult onset tic disorders.","volume":"68","author":"S Chouinard","year":"2000","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"ref-54","doi-asserted-by":"publisher","first-page":"436-446","DOI":"10.1111\/j.1939-0025.1964.tb02212.x","article-title":"Behavior deviations in a representative sample of children: Variation by sex, age, race, social class and family size.","volume":"34","author":"R Lapouse","year":"1964","journal-title":"Am J Orthopsychiatry."},{"key":"ref-55","first-page":"45-47","article-title":"Prevalence of tic disorders among primary school students in the city of Pavia, Italy.","volume":"89","author":"G Lanzi","year":"2004","journal-title":"Arch Dis Child."},{"key":"ref-56","doi-asserted-by":"publisher","first-page":"1229-1241","DOI":"10.1192\/bjp.115.528.1229","article-title":"Tics and Gilles de la Tourette's syndrome: a follow-up study and critical review.","volume":"115","author":"J Corbett","year":"1969","journal-title":"Br J Psychiatry."},{"key":"ref-57","doi-asserted-by":"publisher","first-page":"892-895","DOI":"10.7499\/j.issn.1008-8830.2014.09.005","article-title":"[Clinical features and risk factors of co-morbid tic disorder in children with attention deficit hyperactivity disorder].","volume":"16","author":"K Zhou","year":"2014","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi."},{"key":"ref-58","doi-asserted-by":"publisher","first-page":"559-565","DOI":"10.1016\/S0006-3223(01)01074-5","article-title":"The familial phenotype of obsessive-compulsive disorder in relation to tic disorders: the Hopkins OCD family study.","volume":"50","author":"M Grados","year":"2001","journal-title":"Biol Psychiatry."},{"key":"ref-59","doi-asserted-by":"publisher","first-page":"1244-1251","DOI":"10.1176\/ajp.149.9.1244","article-title":"Tics and Tourette's disorder: a 2- to 7-year follow-up of 54 obsessive-compulsive children.","volume":"149","author":"H Leonard","year":"1992","journal-title":"Am J Psychiatry."},{"key":"ref-60","doi-asserted-by":"publisher","first-page":"628-634","DOI":"10.1192\/bjp.150.5.628","article-title":"Tics and heredity. A study of the relatives of child tiqueurs.","volume":"150","author":"D Zausmer","year":"1987","journal-title":"Br J Psychiatry."},{"key":"ref-61","doi-asserted-by":"publisher","first-page":"1200-1201","DOI":"10.1001\/archneur.1988.00520350038012","article-title":"Transient tic disorder and the spectrum of Tourette's syndrome.","volume":"45","author":"R Kurlan","year":"1988","journal-title":"Arch Neurol."},{"key":"ref-62","doi-asserted-by":"publisher","first-page":"652-658","DOI":"10.1212\/WNL.42.3.652","article-title":"Relationship of birth weight to the phenotypic expression of Gilles de la Tourette's syndrome in monozygotic twins.","volume":"42","author":"T Hyde","year":"1992","journal-title":"Neurology."},{"key":"ref-63","doi-asserted-by":"publisher","first-page":"138-146","DOI":"10.1097\/00004583-198403000-00004","article-title":"Tourette's syndrome and attention deficit disorder with hyperactivity: are they genetically related?","volume":"23","author":"D Comings","year":"1984","journal-title":"J Am Acad Child Psychiatry."},{"key":"ref-64","doi-asserted-by":"publisher","first-page":"75-82","DOI":"10.1007\/s10578-015-0545-z","article-title":"Prenatal maternal smoking and Tourette Syndrome: A nationwide register study.","volume":"47","author":"S Leivonen","year":"2016","journal-title":"Child Psychiatry Hum Dev."},{"key":"ref-65","doi-asserted-by":"publisher","first-page":"40-45","DOI":"10.1192\/bjp.bp.112.125468","article-title":"Association between pre- and perinatal exposures and Tourette syndrome or chronic tic disorder in the ALSPAC cohort.","volume":"204","author":"C Mathews","year":"2014","journal-title":"Br J Psychiatry."},{"key":"ref-66","doi-asserted-by":"publisher","first-page":"755-764","DOI":"10.1007\/s00787-010-0115-7","article-title":"Severe psychosocial stress and heavy cigarette smoking during pregnancy: an examination of the pre- and perinatal risk factors associated with ADHD and Tourette syndrome.","volume":"19","author":"M Motlagh","year":"2010","journal-title":"Eur Child Adolesc Psychiatry."},{"key":"ref-67","doi-asserted-by":"publisher","first-page":"115-121","DOI":"10.1097\/DBP.0b013e31819e6a33","article-title":"Prenatal and perinatal morbidity in children with Tourette syndrome and attention-deficit hyperactivity disorder.","volume":"30","author":"T Pringsheim","year":"2009","journal-title":"J Dev Behav Pediatr."},{"key":"ref-68","doi-asserted-by":"publisher","first-page":"65-74","DOI":"10.1016\/j.dcn.2014.08.005","article-title":"Reward enhances tic suppression in children within months of tic disorder onset.","volume":"11","author":"D Greene","year":"2015","journal-title":"Dev Cogn Neurosci."},{"key":"ref-69","doi-asserted-by":"publisher","first-page":"787-793","DOI":"10.1007\/s00702-007-0014-3","article-title":"Is onset of Tourette syndrome influenced by life events?","volume":"115","author":"N Horesh","year":"2008","journal-title":"J Neural Transm (Vienna)."},{"key":"ref-70","doi-asserted-by":"publisher","first-page":"1129-1136","DOI":"10.1001\/archpsyc.1996.01830120067012","article-title":"The Great Smoky Mountains Study of Youth. Goals, design, methods, and the prevalence of DSM-III-R disorders.","volume":"53","author":"E Costello","year":"1996","journal-title":"Arch Gen Psychiatry."},{"key":"ref-71","article-title":"Personal communication to Black KJ.","author":"E Costello","year":"1999"},{"key":"ref-72","first-page":"185-199","article-title":"[Signs, course and prognosis of tics in children and juveniles (author's transl)].","volume":"186","author":"H Remschmidt","year":"1974","journal-title":"Klin Padiatr."},{"key":"ref-73","first-page":"629-630","article-title":"Follow-up study of children of childhood tiqueurs.","volume":"13","author":"K Abe","year":"1978","journal-title":"Biol Psychiatry."},{"key":"ref-74","first-page":"304-310","article-title":"[Tics in childhood].","volume":"86","author":"L St\u00e1rkov\u00e1","year":"1990","journal-title":"Cesk Psychiatr."},{"key":"ref-75","doi-asserted-by":"publisher","first-page":"115-124","DOI":"10.1212\/WNL.27.2.115","article-title":"Gilles de la Tourette's syndrome: clinical, genetic, psychologic, and biochemical aspects in 21 selected families.","volume":"27","author":"R Eldridge","year":"1977","journal-title":"Neurology."},{"key":"ref-76","doi-asserted-by":"publisher","first-page":"S29-S31","DOI":"10.1016\/S0387-7604(03)90005-2","article-title":"Tourette's syndrome in Taiwan: an epidemiological study of tic disorders in an elementary school at Taipei County.","volume":"25","author":"H Wang","year":"2003","journal-title":"Brain Dev."},{"key":"ref-77","doi-asserted-by":"publisher","first-page":"611-617","DOI":"10.1176\/appi.ajp.158.4.611","article-title":"Impact of tic disorders on ADHD outcome across the life cycle: findings from a large group of adults with and without ADHD.","volume":"158","author":"T Spencer","year":"2001","journal-title":"Am J Psychiatry."},{"key":"ref-78","doi-asserted-by":"publisher","first-page":"1079-1080","DOI":"10.1001\/archneur.1985.04060100061023","article-title":"Recurrence of childhood multiple tic in late adult life.","volume":"42","author":"H Klawans","year":"1985","journal-title":"Arch Neurol."},{"key":"ref-79","doi-asserted-by":"publisher","first-page":"936-940","DOI":"10.1212\/01.WNL.0000086370.10186.7C","article-title":"Objective assessments of longitudinal outcome in Gilles de la Tourette's syndrome.","volume":"61","author":"E Pappert","year":"2003","journal-title":"Neurology."},{"key":"ref-80","doi-asserted-by":"publisher","first-page":"784-788","DOI":"10.1212\/WNL.42.4.784","article-title":"Adult tics in Gilles de la Tourette's syndrome: description and risk factors.","volume":"42","author":"C Goetz","year":"1992","journal-title":"Neurology."},{"key":"ref-81","doi-asserted-by":"crossref","first-page":"126-133","DOI":"10.1097\/00004583-198403000-00002","article-title":"Gilles de la Tourette's syndrome. An overview of clinical experience.","volume":"23","author":"R Bruun","year":"1984","journal-title":"J Am Acad Child Psychiatry."},{"key":"ref-82","first-page":"68-76","article-title":"Follow-up study of the tic disorders.","author":"Z Shin","year":"1996","journal-title":"J Korean Acad Child Adolesc Psychiatry."},{"key":"ref-83","doi-asserted-by":"publisher","first-page":"685-695","DOI":"10.1097\/00004583-200106000-00014","article-title":"Prospective, longitudinal study of tic, obsessive-compulsive, and attention-deficit\/hyperactivity disorders in an epidemiological sample.","volume":"40","author":"B Peterson","year":"2001","journal-title":"J Am Acad Child Adolesc Psychiatry."},{"key":"ref-84","doi-asserted-by":"publisher","first-page":"31-35","DOI":"10.1016\/j.jaapos.2013.11.007","article-title":"The long-term outcomes of ocular tics in a pediatric neuro-ophthalmology practice.","volume":"18","author":"E Bisker","year":"2014","journal-title":"J AAPOS."},{"key":"ref-85","first-page":"198-208","article-title":"A clinical study of tic disorder in Korea.","volume":"24","author":"K Hong","year":"1981","journal-title":"J Korean Pediatr Soc."},{"key":"ref-86","doi-asserted-by":"crossref","first-page":"967-970","DOI":"10.1542\/peds.83.6.967","article-title":"Functional blinking in childhood.","volume":"83","author":"T Vrabec","year":"1989","journal-title":"Pediatrics."},{"key":"ref-87","doi-asserted-by":"publisher","first-page":"537-542","DOI":"10.1136\/adc.29.148.537","article-title":"The treatment of tics in childhood; a review and a follow-up study.","volume":"29","author":"D Zausmer","year":"1954","journal-title":"Arch Dis Child."},{"key":"ref-88","doi-asserted-by":"crossref","first-page":"261-268","DOI":"10.1111\/j.1651-2227.1962.tb06540.x","article-title":"A follow-up study of children with tics.","volume":"51","author":"E Torup","year":"1962","journal-title":"Acta Paediatr."},{"key":"ref-89","doi-asserted-by":"publisher","first-page":"427-440","DOI":"10.1001\/archpsyc.58.5.427","article-title":"Regional brain and ventricular volumes in Tourette syndrome.","volume":"58","author":"B Peterson","year":"2001","journal-title":"Arch Gen Psychiatry."},{"key":"ref-90","first-page":"701","article-title":"\u201cCan you stop that?\u201d Ability to suppress tics is present within months of tic onset, and can predict future clinical outcome.","author":"D Greene","year":"2012"},{"key":"ref-91","doi-asserted-by":"publisher","first-page":"330-336","DOI":"10.1001\/archpsyc.56.4.330","article-title":"Long-term methylphenidate therapy in children with comorbid attention-deficit hyperactivity disorder and chronic multiple tic disorder.","volume":"56","author":"K Gadow","year":"1999","journal-title":"Arch Gen Psychiatry."},{"key":"ref-92","doi-asserted-by":"publisher","first-page":"641-657","DOI":"10.1016\/B978-0-444-52014-2.00046-X","article-title":"Tourette syndrome and other tic disorders.","volume":"100","author":"H Singer","year":"2011","journal-title":"Handb Clin Neurol."},{"key":"ref-93","doi-asserted-by":"publisher","first-page":"103-105","DOI":"10.1001\/archpedi.160.1.103","article-title":"Discussing outcome in Tourette syndrome.","volume":"160","author":"H Singer","year":"2006","journal-title":"Arch Pediatr Adolesc Med."},{"key":"ref-94","article-title":"A cursing brain? The histories of Tourette syndrome.","author":"H Kushner","year":"1999"},{"key":"ref-95","doi-asserted-by":"publisher","first-page":"776-780","DOI":"10.1097\/01.nmd.0000144696.14555.c4","article-title":"Reexamining tic persistence and tic-associated impairment in Tourette's Disorder: Findings from a naturalistic follow-up study.","volume":"192","author":"B Coffey","year":"2004","journal-title":"J Nerv Ment Dis."},{"key":"ref-96","article-title":"Three promising ideas in psychiatric drug development.","author":"T Insel","year":"2012"},{"key":"ref-97","article-title":"The treatment of dementia paralytica by malaria inoculation (Nobel lecture) [online].","author":"J Wagner-Jauregg","year":"1927"},{"key":"ref-98","doi-asserted-by":"publisher","first-page":"227-233","DOI":"10.3109\/10401239409149009","article-title":"The course of tics in Tourette syndrome: a 5-year follow-up study.","volume":"6","author":"C de Groot","year":"1994","journal-title":"Ann Clin Psychiatry."},{"key":"ref-99","doi-asserted-by":"publisher","first-page":"1253-1258","DOI":"10.1212\/01.wnl.0000180957.98702.69","article-title":"Caudate volumes in childhood predict symptom severity in adults with Tourette syndrome.","volume":"65","author":"M Bloch","year":"2005","journal-title":"Neurology."},{"key":"ref-100","doi-asserted-by":"publisher","first-page":"65-69","DOI":"10.1001\/archpedi.160.1.65","article-title":"Adulthood outcome of tic and obsessive-compulsive symptom severity in children with Tourette syndrome.","volume":"160","author":"M Bloch","year":"2006","journal-title":"Arch Pediatr Adolesc Med."},{"key":"ref-101","first-page":"1-16","article-title":"Phenomenology of tics and natural history of tic disorders.","volume":"99","author":"J Leckman","year":"2006","journal-title":"Adv Neurol."},{"key":"ref-102","doi-asserted-by":"publisher","first-page":"291-297","DOI":"10.1007\/s00127-010-0194-2","article-title":"Predictors of early adulthood quality of life in 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Bull."},{"key":"ref-106","doi-asserted-by":"publisher","first-page":"138-144","DOI":"10.1177\/0009922814550396","article-title":"Tourette Syndrome: a general pediatrician's 35-year experience at a single center with follow-up in adulthood.","volume":"54","author":"D Byler","year":"2015","journal-title":"Clin Pediatr (Phila)."},{"key":"ref-107","doi-asserted-by":"publisher","first-page":"S24-S28","DOI":"10.1016\/S0387-7604(03)90004-0","article-title":"Phenomenology of tics and natural history of tic disorders.","volume":"25","author":"J Leckman","year":"2003","journal-title":"Brain Dev."},{"key":"ref-108","doi-asserted-by":"publisher","first-page":"134-145","DOI":"10.1037\/0894-4105.12.1.134","article-title":"Visual-motor integration functioning in children with Tourette syndrome.","volume":"12","author":"R Schultz","year":"1998","journal-title":"Neuropsychology."},{"key":"ref-109","doi-asserted-by":"publisher","first-page":"1277-1284","DOI":"10.1176\/ajp.154.9.1277","article-title":"Decreased motor inhibition in Tourette's disorder: evidence from transcranial magnetic stimulation.","volume":"154","author":"U Ziemann","year":"1997","journal-title":"Am J Psychiatry."},{"key":"ref-110","doi-asserted-by":"publisher","first-page":"37-40","DOI":"10.1016\/S0304-3940(99)00575-3","article-title":"Deficient motor control in children with tic disorder: evidence from transcranial magnetic stimulation.","volume":"272","author":"G Moll","year":"1999","journal-title":"Neurosci Lett."},{"key":"ref-111","doi-asserted-by":"publisher","first-page":"85-89","DOI":"10.1212\/WNL.58.1.85","article-title":"Disproportionate increases of white matter in right frontal lobe in Tourette syndrome.","volume":"58","author":"K Fredericksen","year":"2002","journal-title":"Neurology."},{"key":"ref-112","doi-asserted-by":"publisher","first-page":"551-559","DOI":"10.1111\/j.1469-7610.2005.01561.x","article-title":"Fine-motor skill deficits in childhood predict adulthood tic severity and global psychosocial functioning in Tourette's syndrome.","volume":"47","author":"M Bloch","year":"2006","journal-title":"J Child Psychol Psychiatry."},{"key":"ref-113","doi-asserted-by":"publisher","first-page":"417-420","DOI":"10.1901\/jaba.2004.37-417","article-title":"Creating tic suppression: comparing the effects of verbal instruction to differential reinforcement.","volume":"37","author":"D Woods","year":"2004","journal-title":"J Appl Behav Anal."},{"key":"ref-114","doi-asserted-by":"publisher","DOI":"10.1111\/desc.12407","article-title":"Multivariate pattern classification of pediatric Tourette syndrome using functional connectivity MRI.","author":"D Greene","year":"2016","journal-title":"Dev Sci."},{"key":"ref-115","doi-asserted-by":"publisher","first-page":"1259-1268","DOI":"10.1001\/archpsyc.61.12.1259","article-title":"Habit learning in Tourette syndrome: a translational neuroscience approach to a developmental psychopathology.","volume":"61","author":"R Marsh","year":"2004","journal-title":"Arch Gen Psychiatry."},{"key":"ref-116","doi-asserted-by":"publisher","first-page":"237-45","DOI":"10.1007\/s10802-007-9173-9","article-title":"Durability, negative impact, and neuropsychological predictors of tic suppression in children with chronic tic disorder.","volume":"36","author":"D Woods","year":"2008","journal-title":"J Abnorm Child Psychol."},{"key":"ref-117","doi-asserted-by":"publisher","first-page":"1013-1016","DOI":"10.1001\/archneur.1993.00540100012008","article-title":"Definitions and classification of tic disorders.","volume":"50","year":"1993","journal-title":"Archives of Neurology."},{"key":"ref-118","article-title":"The ICD-10 Classification of Mental and 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Tourette's syndrome and chronic multiple tics among relatives of Tourette's syndrome patients obtained by direct interview.","volume":"23","author":"D Pauls","year":"1984","journal-title":"J Am Acad Child Psychiatry."},{"key":"ref-124","doi-asserted-by":"publisher","first-page":"548-555","DOI":"10.1097\/00004583-200005000-00007","article-title":"Tourette's disorder: epidemiology and comorbidity in primary school children.","volume":"39","author":"B Kadesjo","year":"2000","journal-title":"J Am Acad Child Adolesc Psychiatry."},{"key":"ref-125","doi-asserted-by":"publisher","first-page":"41-47","DOI":"10.1016\/j.brat.2008.10.013","article-title":"The development of stimulus control over tics: a potential explanation for contextually-based variability in the symptoms of Tourette syndrome.","volume":"47","author":"D Woods","year":"2009","journal-title":"Behav Res Ther."},{"key":"ref-126","doi-asserted-by":"publisher","first-page":"693-697","DOI":"10.1002\/mds.1159","article-title":"Home alone: methods to maximize tic expression for objective videotape assessments in Gilles de la Tourette syndrome.","volume":"16","author":"C Goetz","year":"2001","journal-title":"Mov Disord."},{"key":"ref-127","doi-asserted-by":"publisher","first-page":"2108-2112","DOI":"10.1212\/WNL.53.9.2108","article-title":"The Tourette Syndrome Diagnostic Confidence Index: development and clinical associations.","volume":"53","author":"M Robertson","year":"1999","journal-title":"Neurology."},{"key":"ref-128","doi-asserted-by":"publisher","first-page":"101-105","DOI":"10.1055\/s-2008-1081457","article-title":"Limited knowledge of Tourette syndrome causes delay in diagnosis.","volume":"39","author":"N Mol Debes","year":"2008","journal-title":"Neuropediatrics."},{"key":"ref-129","article-title":"DSM-5 Diagnostic Criteria and Classification of Tourette\u2019s Disorder 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Classificatory challenges and an appraisal of the DSM criteria.","volume":"11","author":"M Robertson","year":"2014","journal-title":"Asian J Psychiatr."},{"key":"ref-132","doi-asserted-by":"publisher","first-page":"51-58","DOI":"10.1590\/1516-4446-2013-1274","article-title":"Tourette and tic disorders in ICD-11: standing at the diagnostic crossroads.","volume":"36","author":"D Woods","year":"2014","journal-title":"Rev Bras Psiquiatr."},{"key":"ref-133","first-page":"431108","article-title":"Diagnosis and management of Tourette syndrome: Practical aspects.","volume":"2","author":"R Freeman","year":"1997","journal-title":"Medscape Psychiatry & Mental Health eJournal."},{"key":"ref-134","first-page":"15-18","article-title":"[Simple tic disease in children. A report on 93 cases (author's transl)].","volume":"136","author":"P Debray-Ritzen","year":"1980","journal-title":"Rev Neurol (Paris)."},{"key":"ref-135","doi-asserted-by":"publisher","first-page":"1383-1388","DOI":"10.1212\/WNL.57.8.1383","article-title":"Prevalence of tics in schoolchildren and association with placement in special education.","volume":"57","author":"R Kurlan","year":"2001","journal-title":"Neurology."},{"key":"ref-136","doi-asserted-by":"publisher","first-page":"1006-1011","DOI":"10.1001\/archpsyc.1989.01810110048007","article-title":"The Yale-Brown Obsessive Compulsive Scale. I. development, use, and reliability.","volume":"46","author":"W Goodman","year":"1989","journal-title":"Arch Gen Psychiatry."},{"key":"ref-137","doi-asserted-by":"publisher","first-page":"1012-1016","DOI":"10.1001\/archpsyc.1989.01810110054008","article-title":"The Yale-Brown Obsessive Compulsive Scale. II. validity.","volume":"46","author":"W Goodman","year":"1989","journal-title":"Arch Gen Psychiatry."},{"key":"ref-138","doi-asserted-by":"publisher","first-page":"566-573","DOI":"10.1097\/00004583-198907000-00015","article-title":"The Yale Global Tic Severity Scale: Initial testing of a clinician-rated scale of tic severity.","volume":"28","author":"J Leckman","year":"1989","journal-title":"J Am Acad Child Adolesc Psychiatry."},{"key":"ref-139","doi-asserted-by":"publisher","first-page":"387(slides)","DOI":"10.7490\/f1000research.1111462.1","article-title":"Chewing, rocking, pacing, echoing: Differential diagnosis and importance of stereotyped movements [v1; not peer reviewed].","volume":"5","author":"K Black","year":"2016","journal-title":"F1000Res."},{"key":"ref-140","article-title":"A Developmental Study of the Behavior Problems of Normal Children Between 21 Months and 14 Years.","author":"J Macfarlane","year":"1954"},{"key":"ref-141","article-title":"Merriam-Webster Incorporated. s.v. \"tic\"","year":"2015"}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/5-696\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/5-696\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/5-696\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T21:28:22Z","timestamp":1655501302000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/5-696\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,18]]},"references-count":142,"URL":"https:\/\/doi.org\/10.12688\/f1000research.8428.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.9072.r13533","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.9072.r13530","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.9072.r13477","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.9072.r13477","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.9072.r13530","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.9072.r13533","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,18]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/5-696\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.9072.r13477, Andreas Hartmann, Department of Neurology, Assistance Publique- Hopitaux de Paris, Paris, France, 20 Apr 2016, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/5-696\/v1#referee-response-13477","order":0,"name":"referee-response-13477","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Kevin J Black<\/b>; <i>Posted: 29 Apr 2016<\/i>; We appreciate Prof. Hartmann's thoughtful comments.","URL":"https:\/\/f1000research.com\/articles\/5-696\/v1#referee-comment-1949","order":1,"name":"referee-comment-1949","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.9072.r13533, Andrea Cavanna, School of Life and Health Sciences, Aston Brain Centre, Wellcome Trust Laboratory for Magnetoencephalographic (MEG) studies, Aston University, Birmingham, UK, 28 Apr 2016, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/5-696\/v1#referee-response-13533","order":2,"name":"referee-response-13533","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Kevin J Black<\/b>; <i>Posted: 29 Apr 2016<\/i>; Thank you.","URL":"https:\/\/f1000research.com\/articles\/5-696\/v1#referee-comment-1950","order":3,"name":"referee-comment-1950","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.9072.r13530, Jeremy S. Stern, Department of Neurology, St. George's Hospital and Medical School, London, UK, 03 May 2016, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/5-696\/v1#referee-response-13530","order":4,"name":"referee-response-13530","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Kevin J Black<\/b>; <i>Posted: 03 May 2016<\/i>; Thank you for your thoughtful comments.&nbsp;I agree with you and Prof. Hartmann that the science supports unifying Tourette's disorder \/ Gilles de la Tourette syndrome and Chronic \/ Persistent Motor [or Phonic] Tic Disorder. &quot;Chronic tic disorder&quot; would be my vote for nomenclature. Family and follow-up studies provide the most important evidence for this viewpoint, but phenomenology is another important clue. <sup>1<\/sup>&nbsp;Walkup et al provide a thoughtful dissent. <sup>2<\/sup>&nbsp;I would argue that whether Provisional Tic Disorder differs meaningfully&nbsp;from the chronic tic disorders remains an important and inadequately studied question.1.&nbsp;Robins E, Guze SB: Establishment of diagnostic validity in psychiatric illness: Its application to schizophrenia. Am J Psychiatry 126(7):983-987,&nbsp;1970. doi:&nbsp;10.1176\/ajp.126.7.9832. Walkup JT, Ferr&atilde;o Y, Leckman JF, Stein DJ, Singer H:&nbsp;Tic disorders: some key issues for DSM-V. Depress Anxiety&nbsp;27(6):600\u2013610, 2010, at p. 603.&nbsp;doi:&nbsp;10.1002\/da.20711","URL":"https:\/\/f1000research.com\/articles\/5-696\/v1#referee-comment-1955","order":5,"name":"referee-comment-1955","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"Research reported in this publication was supported by the Eunice Kennedy Shriver National Institute Of Child Health & Human Development of the National Institutes of Health (NIH) under Award Number U54 HD087011 to the Intellectual and Developmental Disabilities Research Center at Washington University, by NIH grants K24 MH087913, R21 NS091635, K01 MH104592, K12 NS001690, by the McDonnell Center for Systems Neuroscience at Washington University, by a NARSAD Young Investigator Award to DJG from the Brain & Behavior Research Foundation, and by the Tourette Association of America. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or any of the other funders. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":6,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}