{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:09:42Z","timestamp":1772168982444,"version":"3.50.1"},"reference-count":9,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T00:00:00Z","timestamp":1463011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    Gitelman syndrome is an inherited tubulopathy leading to a hypokalaemic metabolic alkalosis with hypomagnesaemia and hypocalciuria. Most cases are due to mutations in\n                    <ns4:italic>SLC12A3<\/ns4:italic>\n                    , encoding the apical thiazide sensitive co-transporter in the distal convoluted tubule. Musculoskeletal effects of Gitelman syndrome are common, including muscle weakness, tetany and cramps. Chronic hypomagnesaemia can lead to chondrocalcinosis, which often affects knees but can affect other joints. Here we present a case of Gitelman syndrome complicated by cervical chondrocalcinosis leading to neck pain and numbness of the fingers. Treatments directed at correcting both hypokalaemia and hypomagnesaemia were initiated and allowed conservative non-surgical management of the neck pain. Recognition of chondrocalcinosis is important and treatments must be individualised to correct the underlying hypomagnesaemia.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.8732.1","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T06:20:07Z","timestamp":1463034007000},"page":"875","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Cervical chondrocalcinosis as a complication of Gitelman syndrome"],"prefix":"10.12688","volume":"5","author":[{"given":"Zahra","family":"Iqbal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Mead","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1881-3782","authenticated-orcid":false,"given":"John A.","family":"Sayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2016,5,12]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1750-1172-3-22","article-title":"Gitelman syndrome.","volume":"3","author":"N Knoers","year":"2008","journal-title":"Orphanet J Rare Dis."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"459-70","DOI":"10.1177\/000456320103800503","article-title":"Diagnosis and clinical biochemistry of inherited tubulopathies.","volume":"38","author":"J Sayer","year":"2001","journal-title":"Ann Clin Biochem."},{"key":"ref-3","doi-asserted-by":"crossref","first-page":"594-8","DOI":"10.5301\/jn.5000256","article-title":"It is never too late for a genetic disease: a case of a 79-year-old man with persistent hypokalemia.","volume":"26","author":"G Brambilla","year":"2013","journal-title":"J Nephrol."},{"key":"ref-4","first-page":"1840-2","article-title":"Chondrocalcinosis secondary to hypomagnesemia in Gitelman's syndrome.","volume":"32","author":"H Ea","year":"2005","journal-title":"J Rheumatol."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"710-7","DOI":"10.1046\/j.1523-1755.2001.059002710.x","article-title":"Gitelman's syndrome revisited: an evaluation of symptoms and health-related quality of life.","volume":"59","author":"D Cruz","year":"2001","journal-title":"Kidney Int."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"1496-501","DOI":"10.1002\/art.23106","article-title":"Hypomagnesemia associated with chondrocalcinosis: a cross-sectional study.","volume":"57","author":"P Richette","year":"2007","journal-title":"Arthritis Rheum."},{"key":"ref-7","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcw045","article-title":"Chondrocalcinosis and Gitelman syndrome.","author":"Z Iqbal","year":"2016","journal-title":"QJM."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"610-3","DOI":"10.1093\/rheumatology\/kep324","article-title":"Gitelman syndrome, calcium pyrophosphate dihydrate deposition disease and crowned dens syndrome. A new association?","volume":"49","author":"M Gutierrez","year":"2010","journal-title":"Rheumatology (Oxford)."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"347-50","DOI":"10.1159\/000013614","article-title":"Hypomagnesemia and chondrocalcinosis in Bartter's and Gitelman's syndrome: review of the pathogenetic mechanisms.","volume":"20","author":"L Cal\u00f2","year":"2000","journal-title":"Am J Nephrol."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/5-875\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/5-875\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/5-875\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T13:15:45Z","timestamp":1544015745000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/5-875\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,12]]},"references-count":9,"URL":"https:\/\/doi.org\/10.12688\/f1000research.8732.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.9396.r13809","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.9396.r14146","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.9396.r13933","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.9396.r14146","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.9396.r13933","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.9396.r13809","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,12]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/5-875\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.9396.r13809, Coralie Bingham, Renal Unit, Royal Devon and Exeter Hospital, Exeter, UK, 16 May 2016, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/5-875\/v1#referee-response-13809","order":0,"name":"referee-response-13809","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.9396.r14146, Nicholas G Larkins, Princess Margaret Hospital, Perth, WA, Australia, 03 Jun 2016, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/5-875\/v1#referee-response-14146","order":1,"name":"referee-response-14146","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.9396.r13933, Andrew Mallett, Department of Renal Medicine & Conjoint Statewide Renal Genetics Program, Royal Brisbane and Women's Hospital, Brisbane, Qld, Australia, 13 Jun 2016, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/5-875\/v1#referee-response-13933","order":2,"name":"referee-response-13933","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"JAS is supported by the Northern Counties Kidney Research Fund and the Medical Research Council (MR\/M012212\/1). The authors have no conflicts of interest to declare. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}