{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:09:19Z","timestamp":1772168959465,"version":"3.50.1"},"reference-count":13,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background:<\/ns4:bold>\n                  <\/ns4:p>\n                  <ns4:p>Alien hand syndrome [AHS] is a rare and ill-defined neurological disorder. It produces complex, goal-directed motion of one hand that is involuntarily instigated. This syndrome characteristically arises after brain trauma, brain surgery, stroke or encephalitis. We describe a case of AHS in a patient who had a previous episode of subarachnoid hemorrhage affecting the left frontal lobe and corpus callosum.<\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Case presentation:<\/ns4:bold>\n                  <\/ns4:p>\n                  <ns4:p>An 84-year-old woman presented to the emergency department complaining of headaches and several episodes of her left arm moving as if it was groping around trying to grab at her own body. A computed tomography scan of the head demonstrated an acute left superior frontal hemorrhage with compression of the corpus callosum. Transcranial Doppler report showed no significant abnormality in the insonated vessels. After being stabilized for the acute bleed, she was treated with clonazepam 0.5 mgat night for the uncontrolled hand movements. Her movements resolved by her next month follow up. The diagnosis of AHS was made based on her clinical presentation, characterization of the movement and localization correlating with findings in neuroimaging.<\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusion:<\/ns4:bold>\n                  <\/ns4:p>\n                  <ns4:p>We document a rare neurologic disorder seen in patients presenting with a history of previous strokes and a typical description of involuntary and unintentional, uncontrolled unilateral arm movements with repetitive grasping. The present case has a combination of frontal and callosal lesions.\u00a0 These findings appear to support a potential destruction leading to the rare syndrome.<\/ns4:p>","DOI":"10.12688\/f1000research.9096.1","type":"journal-article","created":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T09:35:12Z","timestamp":1467365712000},"page":"1564","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Case Report: 84 year-old woman with alien hand syndrome"],"prefix":"10.12688","volume":"5","author":[{"given":"Ihtesham Aatif","family":"Qureshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Korya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darine","family":"Kassar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"Moussavi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2016,7,1]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"83-85","DOI":"10.1136\/jnnp.68.1.83","article-title":"Subjective experience, involuntary movement, and posterior alien hand syndrome.","volume":"68","author":"T Bundick","year":"2000","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"E02","DOI":"10.1176\/appi.neuropsych.12080193","article-title":"The \"brother's arm:\" alien hand syndrome after right posterior parietal lesion.","volume":"25","author":"H Shereef","year":"2013","journal-title":"J Neuropsychiatry Clin Neurosci."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"261-277","DOI":"10.1177\/1534582303260119","article-title":"The alien hand: cases, categorizations, and anatomical correlates.","volume":"2","author":"L Scepkowski","year":"2003","journal-title":"Behav Cogn Neurosci Rev."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"19-24","DOI":"10.1212\/WNL.42.1.19","article-title":"Two alien hand syndromes.","volume":"42","author":"T Feinberg","year":"1992","journal-title":"Neurology."},{"key":"ref-5","first-page":"295-303","article-title":"Positive and negative aspects of cerebral cortical functions.","volume":"17","author":"D Denny-Brown","year":"1956","journal-title":"N C Med J."},{"key":"ref-6","doi-asserted-by":"crossref","first-page":"228-38","DOI":"10.1097\/00002060-199010000-00002","article-title":"The alien hand sign. Localization, lateralization and recovery.","volume":"69","author":"G Goldberg","year":"1990","journal-title":"Am J Phys Med Rehabil."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"287-99","DOI":"10.1016\/S0010-9452(08)70005-4","article-title":"Alien hand syndrome: influence of neglect on the clinical presentation of frontal and callosal variants.","volume":"33","author":"J Chan","year":"1977","journal-title":"Cortex."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"556-560","DOI":"10.5535\/arm.2012.36.4.556","article-title":"Alien hand syndrome in stroke - case report & neurophysiologic study -.","volume":"36","author":"Y Park","year":"2012","journal-title":"Ann Rehabil Med."},{"key":"ref-9","first-page":"203-39","article-title":"linksseitigemotorischeApraxie. 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The strange hand sign].","volume":"126","author":"S Brion","year":"1972","journal-title":"Rev Neurol (Paris)."},{"key":"ref-12","first-page":"308-59","article-title":"The callosal syndrome","author":"J Bogen","year":"1979"},{"key":"ref-13","doi-asserted-by":"publisher","first-page":"728-732","DOI":"10.1016\/j.apmr.2006.02.002","article-title":"Alien hand syndrome in stroke: a report of 2 cases and review of the literature.","volume":"87","author":"M Kikkert","year":"2006","journal-title":"Arch Phys Med Rehabil."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/5-1564\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/5-1564\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/5-1564\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T12:50:54Z","timestamp":1544014254000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/5-1564\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,1]]},"references-count":13,"URL":"https:\/\/doi.org\/10.12688\/f1000research.9096.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.9790.r14782","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.9790.r16625","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.9790.r18081","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.9790.r18081","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.9790.r16625","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.9790.r14782","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,1]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/5-1564\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.9790.r14782, Nizar Souayah, Department of Neurology and Neurosciences, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA, 12 Jul 2016, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/5-1564\/v1#referee-response-14782","order":0,"name":"referee-response-14782","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.9790.r16625, Burak Yulug, L\u00fctf\u00fc Hanoglu, Department of Neurology, University of Istanbul-Medipol, Istanbul, Turkey, 10 Oct 2016, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/5-1564\/v1#referee-response-16625","order":1,"name":"referee-response-16625","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.9790.r18081, Mary Ann Thenganatt, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA, 09 Dec 2016, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/5-1564\/v1#referee-response-18081","order":2,"name":"referee-response-18081","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}