{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:10:34Z","timestamp":1772169034543,"version":"3.50.1"},"reference-count":16,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Purpose:<\/ns4:bold>\n                    To determine the safety and efficacy of collagen matrix as a patch graft in glaucoma drainage surgery. Collagen matrix grafts may be advantageous because they do not need to be harvested from human donors.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Methods:<\/ns4:bold>\n                    An institutional, retrospective review of 43 patients with at least 12 months follow-up status post-glaucoma drainage implant surgery were evaluated for signs of tube erosion after initial placement of collagen matrix patch graft.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Results:<\/ns4:bold>\n                    Forty-one of 43 eyes (95.3%) required no intervention for patch graft melting with tube erosion. Average time of follow-up was 32 months (range: 12-45). Two cases had tube erosion at 4 months and 26 months post-op requiring tube revision, which was successfully revised with conjunctiva (4 month erosion) and donor sclera (26 month erosion).\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusion:<\/ns4:bold>\n                    \u00a0 Our results suggest that collagen matrix patch grafts may be used successfully as a patch graft in glaucoma tube shunt surgery, and may be advantageous because they do not have to be harvested from human donors. It is possible that exposure rates may be higher after longer follow-up and with larger numbers of patients. Further research is needed to compare Ologen to traditional graft materials to conclusively determine the safety and efficacy of collagen matrix as a novel patch graft material.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.9232.1","type":"journal-article","created":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T10:55:06Z","timestamp":1470048906000},"page":"1898","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["The use of collagen matrix (Ologen) as a patch graft in glaucoma tube shunt surgery, a retrospective chart review"],"prefix":"10.12688","volume":"5","author":[{"given":"John D.","family":"Stephens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven R.","family":"Sarkisian, 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Gedde","year":"2007","journal-title":"Am J Ophthalmol."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"174-175","DOI":"10.1001\/archopht.1992.01080140024014","article-title":"Late infectious endophthalmitis from exposed glaucoma setons.","volume":"110","author":"D Krebs","year":"1992","journal-title":"Arch Ophthalmol."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"5-10","DOI":"10.1097\/IJG.0b013e31819aa593","article-title":"Revision for exposed anterior segment tubes.","volume":"19","author":"J Kalenak","year":"2010","journal-title":"J Glaucoma."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"143-147","DOI":"10.1097\/00061198-200204000-00010","article-title":"A comparison of glaucoma drainage implant tube coverage.","volume":"11","author":"M Smith","year":"2002","journal-title":"J Glaucoma."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"184-189","DOI":"10.3928\/15428877-20110426-01","article-title":"Use of amniotic membrane graft in glaucoma shunt surgery.","volume":"42","author":"A Anand","year":"2011","journal-title":"Ophthalmic Surg Lasers Imaging."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"649-52","DOI":"10.1097\/IJG.0000000000000018","article-title":"Using a collagen matrix implant (Ologen) versus mitomycin-C as a wound healing modulator in trabeculectomy with the Ex-PRESS mini glaucoma device: a 12-month retrospective review.","volume":"23","author":"M Johnson","year":"2014","journal-title":"J Glaucoma."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"659-62","DOI":"10.1097\/IJG.0b013e3182594f5b","article-title":"Trabeculectomy with combined use of subconjunctival collagen implant and low-dose mitomycin C.","volume":"22","author":"T Dada","year":"2013","journal-title":"J Glaucoma."},{"key":"ref-10","first-page":"76-78","article-title":"Biodegradable implant for tissue repair after glaucoma drainage device surgery.","volume":"21","author":"A Rosentreter","year":"2012","journal-title":"J Glaucoma."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"2172-9","DOI":"10.1016\/j.ophtha.2011.05.003","article-title":"The Ahmed Versus Baerveldt study: design, baseline patient characteristics, and intraoperative complications.","volume":"118","author":"P Christakis","year":"2011","journal-title":"Ophthalmology."},{"key":"ref-12","doi-asserted-by":"publisher","first-page":"804-814.e1","DOI":"10.1016\/j.ajo.2011.10.024","article-title":"Postoperative complications in the Tube Versus Trabeculectomy (TVT) study during five years of follow-up.","volume":"153","author":"S Gedde","year":"2012","journal-title":"Am J Ophthalmol."},{"key":"ref-13","doi-asserted-by":"publisher","first-page":"516-521.e2","DOI":"10.1016\/j.ajo.2015.05.025","article-title":"Glaucoma drainage devices: risk of exposure and infection.","volume":"160","author":"J Levinson","year":"2015","journal-title":"Am J Ophthalmol."},{"key":"ref-14","doi-asserted-by":"publisher","first-page":"e004560","DOI":"10.1136\/bmjopen-2013-004560","article-title":"Risk factors for exposure of glaucoma drainage devices: a retrospective observational study.","volume":"4","author":"K Muir","year":"2014","journal-title":"BMJ Open."},{"key":"ref-15","doi-asserted-by":"publisher","first-page":"1-5","DOI":"10.1155\/2013\/196215","article-title":"Risk factors for tube shunt exposure: a matched case-control study.","volume":"2013","author":"M Koval","year":"2013","journal-title":"J Ophthalmol."},{"key":"ref-16","doi-asserted-by":"publisher","DOI":"10.5256\/f1000research.9232.d130894","article-title":"Dataset 1 in: The Use of Collagen Matrix (Ologen) as a Patch Graft in Glaucoma Tube Shunt Surgery, a Retrospective Chart Review.","author":"J Stephens","year":"2016","journal-title":"F1000Research."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/5-1898\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/5-1898\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/5-1898\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T12:36:20Z","timestamp":1544013380000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/5-1898\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,1]]},"references-count":16,"URL":"https:\/\/doi.org\/10.12688\/f1000research.9232.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.9936.r19745","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.9936.r15561","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.9936.r15375","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.9936.r19745","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.9936.r15561","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.9936.r15375","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,1]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/5-1898\/v1#article-reports","order":0,"name":"referee-status","label":"Referee 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Reports"}},{"value":"10.5256\/f1000research.9936.r19745, Nathan M. Radcliffe, Department of Ophthalmology, School of Medicine, New York University\u00a0(NYU), New York, NY, USA, 01 Feb 2017, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/5-1898\/v1#referee-response-19745","order":2,"name":"referee-response-19745","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This paper was funded in part by Research to Prevent Blindness. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Data associated with the article are available under the terms of the Creative Commons Zero \"No rights reserved\" data waiver (CC0 1.0 Public domain dedication).","order":0,"name":"copyright-info","label":"Copyright"}]}}