{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:23:25Z","timestamp":1776731005519,"version":"3.51.2"},"reference-count":42,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T00:00:00Z","timestamp":1479945600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Male infertility remains a struggle to definitively diagnose and treat with many men labelled as \u201cidiopathic infertility\u201d and eventually requiring assisted reproductive techniques.\u00a0 Along those lines, research groups are continuing to explore current social and environmental factors, including the obesity epidemic, and their effects on male fertility potential.\u00a0 Novel biomarkers of natural fertility status and azoospermia etiology have additionally seen recent attention with ACRV1 and TEX101\/ECM1 assays either currently or soon to be commercially available.\u00a0 Despite these advancements, however, medical treatment options have seen little progress.\u00a0 Though surgical therapies have similarly seen little transformation, groups are exploring the use of testicular sperm for couples with elevated sperm DNA fragmentation and either planned or previously failed IVF\/ICSI.\u00a0 Concerted collaborative efforts will be needed as we move forward to better understand the challenges men face when struggling to conceive.<\/ns4:p>","DOI":"10.12688\/f1000research.9375.1","type":"journal-article","created":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T05:45:06Z","timestamp":1479966306000},"page":"2756","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Recent advances in understanding &amp; 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