{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T12:33:57Z","timestamp":1775738037830,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/gatesopenres.12869.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T00:00:00Z","timestamp":1549324800000}}],"reference-count":80,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T00:00:00Z","timestamp":1549324800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP49038"],"award-info":[{"award-number":["OPP49038"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["gatesopenresearch.org"],"crossmark-restriction":false},"short-container-title":["Gates Open Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background:<\/ns4:bold>\n                    INTERBIO-21\n                    <ns4:sup>st<\/ns4:sup>\n                    is Phase II of the INTERGROWTH-21\n                    <ns4:sup>st<\/ns4:sup>\n                    Project, the population-based, research initiative involving nearly 70,000 mothers and babies worldwide coordinated by Oxford University and performed by a multidisciplinary network of more than 400 healthcare professionals and scientists from 35 institutions in 21 countries worldwide. Phase I, conducted 2008-2015, consisted of nine complementary studies designed to describe optimal human growth and neurodevelopment, based conceptually on the WHO prescriptive approach. The studies generated a set of international standards for monitoring growth and neurodevelopment, which complement the existing WHO Child Growth Standards. Phase II aims to improve the functional classification of the highly heterogenous preterm birth and fetal growth restriction syndromes through a better understanding of how environmental exposures, clinical conditions and nutrition influence patterns of human growth from conception to childhood, as well as specific neurodevelopmental domains and associated behaviors at 2 years of age.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Methods:<\/ns4:bold>\n                    In the INTERBIO-21\n                    <ns4:sup>st<\/ns4:sup>\n                    Newborn Case-Control Study, a major component of Phase II, our objective is to investigate the mechanisms potentially responsible for preterm birth and small for gestational age and their interactions, using deep phenotyping of clinical, growth and epidemiological data and associated nutritional, biochemical, omic and histological profiles. Here we describe the study sites, population characteristics, study design, methodology and standardization procedures for the collection of longitudinal clinical data and biological samples (maternal blood, umbilical cord blood, placental tissue, maternal feces and infant buccal swabs) for the study that was conducted between 2012 and 2018 in Brazil, Kenya, Pakistan, South Africa, Thailand and the UK.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Discussion:<\/ns4:bold>\n                    Our study provides a unique resource for the planned analyses given the range of potentially disadvantageous exposures (including poor nutrition, pregnancy complications and infections) in geographically diverse populations worldwide. The study should enhance current medical knowledge and provide new insights into environmental influences on human growth and neurodevelopment.\n                  <\/ns4:p>","DOI":"10.12688\/gatesopenres.12869.2","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T11:51:51Z","timestamp":1549367511000},"page":"49","update-policy":"https:\/\/doi.org\/10.12688\/gatesopenres.crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Deep clinical and biological phenotyping of the preterm birth and small for gestational age syndromes: The INTERBIO-21st Newborn Case-Control Study protocol"],"prefix":"10.12688","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0135-9317","authenticated-orcid":false,"given":"Stephen H.","family":"Kennedy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2465-2180","authenticated-orcid":false,"given":"Cesar 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Villar","year":"2015","journal-title":"Lancet Glob Health."},{"key":"ref-26","doi-asserted-by":"publisher","first-page":"S841-S54.e2","DOI":"10.1016\/j.ajog.2017.11.564","article-title":"The satisfactory growth and development at 2 years of age of the INTERGROWTH-21st Fetal Growth Standards cohort support its appropriateness for constructing international standards.","volume":"218","author":"J Villar","year":"2018","journal-title":"Am J Obstet Gynecol."},{"key":"ref-27","doi-asserted-by":"publisher","first-page":"e113360","DOI":"10.1371\/journal.pone.0113360","article-title":"The INTERGROWTH-21st Project Neurodevelopment Package: a novel method for the multi-dimensional assessment of neurodevelopment in pre-school age children.","volume":"9","author":"M Fernandes","year":"2014","journal-title":"PLoS One."},{"key":"ref-28","doi-asserted-by":"publisher","first-page":"e0193406","DOI":"10.1371\/journal.pone.0193406","article-title":"Evaluation of the INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) in 2 year-old children.","volume":"13","author":"E Murray","year":"2018","journal-title":"PLoS One."},{"key":"ref-29","article-title":"Neurodevelopmental milestones and associated behaviours are similar among healthy children across diverse geographical locations (manuscript under review)","author":"J Villar"},{"key":"ref-30","first-page":"1-101","article-title":"WHO Child Growth Standards.","volume":"450","author":"M de Onis","year":"2006","journal-title":"Acta Paediatr Suppl."},{"key":"ref-31","article-title":"Screening, assessment and management of neonates and infants with complications associated with Zika virus exposure in utero"},{"key":"ref-32","article-title":"Congenital microcephaly case definitions","year":"2016"},{"key":"ref-33","doi-asserted-by":"publisher","first-page":"j3677","DOI":"10.1136\/bmj.j3677","article-title":"Estimates of burden and consequences of infants born small for gestational age in low and middle income countries with INTERGROWTH-21st standard: analysis of CHERG datasets.","volume":"358","author":"A Lee","year":"2017","journal-title":"BMJ."},{"key":"ref-34","doi-asserted-by":"publisher","first-page":"80-7","DOI":"10.1242\/jeb.107318","article-title":"Dynamics of epigenetic phenomena: intergenerational and intragenerational phenotype 'washout'.","volume":"218","author":"W Burggren","year":"2015","journal-title":"J Exp Biol."},{"key":"ref-35","doi-asserted-by":"publisher","first-page":"58-68","DOI":"10.1111\/mcn.12085","article-title":"Parental height and child growth from birth to 2 years in the WHO Multicentre Growth Reference Study.","volume":"9 Suppl 2","author":"C Garza","year":"2013","journal-title":"Matern Child Nutr."},{"key":"ref-36","doi-asserted-by":"publisher","first-page":"159-224","DOI":"10.1210\/er.2009-0039","article-title":"Child health, developmental plasticity, and epigenetic programming.","volume":"32","author":"Z Hochberg","year":"2011","journal-title":"Endocr Rev."},{"key":"ref-37","doi-asserted-by":"publisher","first-page":"262sr5","DOI":"10.1126\/scitranslmed.3009871","article-title":"Prevention of preterm birth: harnessing science to address the global epidemic.","volume":"6","author":"C Rubens","year":"2014","journal-title":"Sci Transl Med."},{"key":"ref-38","article-title":"The idea of the healthy control is sick","author":"J Olsen","year":"2010"},{"key":"ref-39","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1471-2288-3-21","article-title":"Alternatives for logistic regression in cross-sectional studies: an empirical comparison of models that directly estimate the prevalence ratio.","volume":"3","author":"A Barros","year":"2003","journal-title":"BMC Med Res Methodol."},{"key":"ref-40","doi-asserted-by":"publisher","first-page":"81-6","DOI":"10.1111\/1471-0528.12046","article-title":"Implementation of the INTERGROWTH-21st Project in Brazil.","volume":"120 Suppl 2","author":"M Silveira","year":"2013","journal-title":"BJOG."},{"key":"ref-41","doi-asserted-by":"publisher","first-page":"105-10","DOI":"10.1111\/1471-0528.12045","article-title":"Implementation of the INTERGROWTH-21st Project in Kenya.","volume":"120 Suppl 2","author":"M Carvalho","year":"2013","journal-title":"BJOG."},{"key":"ref-42","doi-asserted-by":"publisher","first-page":"117-22","DOI":"10.1111\/1471-0528.12033","article-title":"Implementation of the INTERGROWTH-21st Project in the UK.","volume":"120 Suppl 2","author":"F Roseman","year":"2013","journal-title":"BJOG."},{"key":"ref-43","doi-asserted-by":"publisher","first-page":"S390-8","DOI":"10.1590\/S0102-311X2008001500004","article-title":"Preterm births, low birth weight, and intrauterine growth restriction in three birth cohorts in Southern Brazil: 1982, 1993 and 2004.","volume":"24 Suppl 3","author":"F Barros","year":"2008","journal-title":"Cad Saude Publica."},{"key":"ref-44","doi-asserted-by":"publisher","first-page":"S27-36","DOI":"10.1177\/15648265040251S104","article-title":"Measurement and standardization protocols for anthropometry used in the construction of a new international growth reference.","volume":"25","author":"M de Onis","year":"2004","journal-title":"Food Nutr Bull."},{"key":"ref-45","doi-asserted-by":"publisher","first-page":"e0142805","DOI":"10.1371\/journal.pone.0142805","article-title":"The Impact of human mobility on HIV transmission in Kenya.","volume":"10","author":"A Isdory","year":"2015","journal-title":"PLoS One."},{"key":"ref-46","doi-asserted-by":"publisher","first-page":"650-7","DOI":"10.1093\/ije\/dys062","article-title":"Profile: The Kilifi Health and Demographic Surveillance System (KHDSS).","volume":"41","author":"J Scott","year":"2012","journal-title":"Int J Epidemiol."},{"key":"ref-47","doi-asserted-by":"publisher","first-page":"449-52","DOI":"10.3109\/14767058.2010.482619","article-title":"Still births-eight years experience at Aga Khan University Hospital Karachi, Pakistan.","volume":"24","author":"S Munim","year":"2011","journal-title":"J Matern Fetal Neonatal Med."},{"key":"ref-48","doi-asserted-by":"publisher","first-page":"220-7","DOI":"10.1111\/1471-0528.13064","article-title":"Declining maternal mortality in the face of persistently high HIV prevalence in a middle-income country.","volume":"122","author":"E Buchmann","year":"2015","journal-title":"BJOG."},{"key":"ref-49","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s13006-017-0109-x","article-title":"Infant feeding knowledge, perceptions and practices among women with and without HIV in Johannesburg, South Africa: a survey in healthcare facilities.","volume":"12","author":"C Mnyani","year":"2017","journal-title":"Int Breastfeed J."},{"key":"ref-50","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s12905-016-0345-z","article-title":"Physical activity and the risk for gestational diabetes mellitus amongst pregnant women living in Soweto: a study protocol.","volume":"16","author":"T Khan","year":"2016","journal-title":"BMC women's health."},{"key":"ref-51","doi-asserted-by":"publisher","first-page":"424-9","DOI":"10.1016\/0035-9203(91)90205-D","article-title":"Malaria during pregnancy in an area of unstable endemicity.","volume":"85","author":"F Nosten","year":"1991","journal-title":"Trans R Soc Trop Med Hyg."},{"key":"ref-52","doi-asserted-by":"publisher","first-page":"395-403","DOI":"10.1002\/uog.7350","article-title":"Obstetric ultrasound scanning by local health workers in a refugee camp on the Thai-Burmese border.","volume":"34","author":"M Rijken","year":"2009","journal-title":"Ultrasound Obstet Gynecol."},{"key":"ref-53","doi-asserted-by":"publisher","first-page":"123","DOI":"10.12688\/f1000research.4190.2","article-title":"Audit of antenatal screening for syphilis and HIV in migrant and refugee women on the Thai-Myanmar border: a descriptive study [version 2; referees: 2 approved].","volume":"3","author":"R McGready","year":"2014","journal-title":"F1000Res."},{"key":"ref-54","doi-asserted-by":"publisher","first-page":"266-73","DOI":"10.1002\/uog.10082","article-title":"Intra- and interobserver variability in fetal ultrasound measurements.","volume":"39","author":"I Sarris","year":"2012","journal-title":"Ultrasound Obstet Gynecol."},{"key":"ref-55","doi-asserted-by":"publisher","first-page":"111-20","DOI":"10.1056\/NEJMoa0803267","article-title":"Timing of elective repeat cesarean delivery at term and neonatal outcomes.","volume":"360","author":"A Tita","year":"2009","journal-title":"N Engl J Med."},{"key":"ref-56","article-title":"INTERBIO-21st Newborn Case-control Study 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Stringer, Division of Global Women\u2019s Health, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 06 Feb 2019, version 2, indexed","URL":"https:\/\/gatesopenresearch.org\/articles\/2-49\/v2#referee-response-26909","order":0,"name":"referee-response-26909","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/gatesopenres.14021.r27249, Errol R. Norwitz, Mother Infant Research Institute (MIRI), Tufts Medical Center, Boston, MA, 30 May 2019, version 2, indexed","URL":"https:\/\/gatesopenresearch.org\/articles\/2-49\/v2#referee-response-27249","order":1,"name":"referee-response-27249","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The work was supported by the INTERGROWTH-21st grant no.49038 from the Bill & Melinda Gates Foundation to the University of Oxford, for which we are very grateful. 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