{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T18:31:32Z","timestamp":1774722692238,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/gatesopenres.13327.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:00:00Z","timestamp":1643760000000}}],"reference-count":116,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:00:00Z","timestamp":1643760000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"UK Department for International Development"},{"DOI":"10.13039\/501100000265","name":"UK Medical Research Council","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]},{"name":"MRC Centre for Global Infectious Disease Analysis","award":["MR\/R015600\/1"],"award-info":[{"award-number":["MR\/R015600\/1"]}]},{"name":"European and Developing Countries Clinical Trials Partnership (EDCTP2) programme"},{"name":"UK Foreign, Commonwealth & Development Office"},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"crossref","award":["OPP1184344"],"award-info":[{"award-number":["OPP1184344"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["gatesopenresearch.org"],"crossmark-restriction":false},"short-container-title":["Gates Open Res"],"abstract":"<ns3:p>\n                    The World Health Organization recently launched its 2021-2030 roadmap,\n                    <ns3:italic>Ending<\/ns3:italic>\n                    <ns3:italic>the<\/ns3:italic>\n                    <ns3:italic>Neglect<\/ns3:italic>\n                    <ns3:italic>to<\/ns3:italic>\n                    <ns3:italic>Attain<\/ns3:italic>\n                    <ns3:italic>the<\/ns3:italic>\n                    <ns3:italic>Sustainable Development Goals<\/ns3:italic>\n                    <ns3:italic>,<\/ns3:italic>\n                    an updated call to arms to end the suffering caused by neglected tropical diseases. Modelling and quantitative analyses played a significant role in forming these latest goals. In this collection, we discuss the insights, the resulting recommendations and identified challenges of public health modelling for 13 of the target diseases: Chagas disease, dengue,\n                    <ns3:italic>gambiense<\/ns3:italic>\n                    human African trypanosomiasis (gHAT), lymphatic filariasis (LF), onchocerciasis, rabies, scabies, schistosomiasis, soil-transmitted helminthiases (STH),\n                    <ns3:italic>Taenia solium<\/ns3:italic>\n                    taeniasis\/ cysticercosis, trachoma, visceral leishmaniasis (VL) and yaws. This piece reflects the three cross-cutting themes identified across the collection, regarding the contribution that modelling can make to timelines, programme design, drug development and clinical trials.\n                  <\/ns3:p>","DOI":"10.12688\/gatesopenres.13327.2","type":"journal-article","created":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T11:00:20Z","timestamp":1643799620000},"page":"112","update-policy":"https:\/\/doi.org\/10.12688\/gatesopenres.crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["How modelling can help steer the course set by the World Health Organization 2021-2030 roadmap on neglected tropical diseases"],"prefix":"10.12688","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1692-899X","authenticated-orcid":false,"given":"Jessica","family":"Clark","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9509-1328","authenticated-orcid":false,"given":"Wilma A.","family":"Stolk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5031-3361","authenticated-orcid":false,"given":"Mar\u00eda-Gloria","family":"Bas\u00e1\u00f1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4425-2264","authenticated-orcid":false,"given":"Luc E.","family":"Coffeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8165-3198","authenticated-orcid":false,"given":"Zulma M.","family":"Cucunub\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1710-6237","authenticated-orcid":false,"given":"Matthew A.","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9788-4858","authenticated-orcid":false,"given":"Louise","family":"Dyson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5392-6884","authenticated-orcid":false,"given":"Katie","family":"Hampson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7585-4743","authenticated-orcid":false,"given":"Michael","family":"Marks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0030-7278","authenticated-orcid":false,"given":"Graham F.","family":"Medley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9688-5960","authenticated-orcid":false,"given":"Timothy M.","family":"Pollington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4699-5931","authenticated-orcid":false,"given":"Joaquin M.","family":"Prada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8414-7648","authenticated-orcid":false,"given":"Kat S.","family":"Rock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Salje","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1510-397X","authenticated-orcid":false,"given":"Jaspreet","family":"Toor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5962-4238","authenticated-orcid":false,"given":"T. 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Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/gatesopenresearch.org\/articles\/5-112\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/gatesopenresearch.org\/articles\/5-112\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/gatesopenresearch.org\/articles\/5-112\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T06:15:56Z","timestamp":1643955356000},"score":1,"resource":{"primary":{"URL":"https:\/\/gatesopenresearch.org\/articles\/5-112\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,2]]},"references-count":116,"URL":"https:\/\/doi.org\/10.12688\/gatesopenres.13327.2","relation":{"has-review":[{"id-type":"doi","id":"10.21956\/gatesopenres.14821.r31726","asserted-by":"subject"},{"id-type":"doi","id":"10.21956\/gatesopenres.14821.r31726","asserted-by":"object"}]},"ISSN":["2572-4754"],"issn-type":[{"value":"2572-4754","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,2]]},"assertion":[{"value":"Indexed","URL":"https:\/\/gatesopenresearch.org\/articles\/5-112\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.21956\/gatesopenres.14821.r31726, Angus McLure, National Centre for Epidemiology and Population Health, Australian National University, Acton, ACT, Australia, 04 Feb 2022, version 2, indexed","URL":"https:\/\/gatesopenresearch.org\/articles\/5-112\/v2#referee-response-31726","order":0,"name":"referee-response-31726","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/gatesopenres.14570.r31306, Margaret C. Baker, Georgetown University, Washington, DC, USA, 04 Jan 2022, version 1, 1 approved, 1 approved with reservations","URL":"https:\/\/gatesopenresearch.org\/articles\/5-112\/v1#referee-response-31306","order":1,"name":"referee-response-31306","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Jessica Clark<\/b>; \n<i>Posted: 28 Jan 2022<\/i>; \n<sub><i>What is less clear is how modeling can inform decision making at a national level to answer similar questions. This would require the use of an interactive tool that can be used by NTD program managers and their partners to input their parameters (e.g. disease agent, vector species, baseline prevalence, different intervention details, etc). They would in turn be provided with predictions on timelines and answers to questions such as: what would be the impact of: increasing coverage? Reducing those never treated by x %? Adding complimentary control methods? Increasing frequency of treatment? Such tools are available for other health areas like maternal and neonatal health (e.g&nbsp;http:\/\/www.healthpolicyplus.com\/ns\/pubs\/18466-18842_MHTools.pdf; \u200b\u200bhttp:\/\/www.mandate4mnh.org\/; Jones-Hepler&nbsp;et al., 2017<sup>1<\/sup>)<\/i><\/sub>   \n<b>A similar point has been raised by reviewer 1. A new final paragraph of the C<i>hallenges <\/i>section has been added. In short, the translation of international-level policy to local-level implementation does mean that local-level specific details are often overlooked, and general policy recommendations fail to meet all conditions of that setting. Whilst providing tools locally is an obvious path to improve national (or smaller) level control, it comes with a trade-off. In making the models more user-friendly, some of the complexities that allow for fine scale tuning of certain parameters may have to become fixed, such that the insight is less specific. There is also the matter of interpretation and understandings the limitations of the models. As such, local expertise is still necessary even in the hands of decision-makers.<\/b>  \n<sub><i>With regards to drug development I am not aware of the need for new drugs for LF or trachoma (the references provided did not collaborate and these are not listed as challenges in the Roadmap).&nbsp;<\/i><\/sub>  \n<b>This misunderstanding was a result of poor sentence structure. We have rectified this by rewriting the opening to the <i>Drug development and clinical study design <\/i>section. &nbsp;<\/b> \n<sub><i>As a reviewer I was asked to comment on whether the article adequately referenced different views and opinions, to which I respond, only partially. The article is authored by modellers who have a much clearer insight into the pro modelling perspective. There are still many in the NTD community who remain skeptical - due to one of the challenges that is clearly presented in this article, that is the reliability of the data on which the models are built. It would be helpful to have all the assumptions, parameters, and data sources used in the models published online in one easy-to-access place. This would enable more informed discussions to take place, across a wider group of participants, as existing evidence is weighed in making policy decisions. It would also be helpful to have a summary from this of the biggest evidence gaps - to drive research and documentation of programmatic results.<\/i><\/sub>  \n<b>It is out with the scope of this article to provide a thorough overview of the data needs to improve modelling insights. There is however a PLoS NTD collection that was cited in the main text. To make this clearer, text has been added text to the&nbsp;<i>Challenges <\/i>section, directing the reader to this in-depth collection. With regards to the assumptions, parameters and data sources; these are provided in every publication that presents modelling results, and the code for each model is public. These are not included here because there are no models specifically presented here. <\/b>","URL":"https:\/\/gatesopenresearch.org\/articles\/5-112\/v2#referee-comment-3497","order":2,"name":"referee-comment-3497","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This work was supported by the Bill and Melinda Gates Foundation through the Neglected Tropical Disease (NTD) Modelling Consortium (OPP1184344).  JT acknowledges funding from the Medical Research Council (MRC) Centre for Global Infectious Disease Analysis (reference MR\/R015600\/1), jointly funded by the UK MRC and the UK Foreign, Commonwealth & Development Office (FCDO), under the MRC\/FCDO Concordat agreement and is also part of the European and Developing Countries Clinical Trials Partnership (EDCTP2) programme supported by the European Union. MGB and MAD acknowledge joint centre funding (grant No. MR\/R015600\/1) by the UK MRC and the UK Department for International Development (DFID) under the MRC\/DFID Concordat agreement which is also part of the EDCTP2 programme supported by the European Union. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}