{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T14:04:37Z","timestamp":1781273077048,"version":"3.54.1"},"update-to":[{"DOI":"10.12688\/gatesopenres.15015.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000}},{"DOI":"10.12688\/gatesopenres.15015.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000}}],"reference-count":55,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1187889"],"award-info":[{"award-number":["OPP1187889"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["gatesopenresearch.org"],"crossmark-restriction":false},"short-container-title":["Gates Open Res"],"abstract":"<ns4:p>\n                    Background Recent trials have confirmed the effectiveness of promising dengue control technologies \u2013 two vaccines and\n                    <ns4:italic>Wolbachia<\/ns4:italic>\n                    . These would generally be applied at the municipal level. To help local officials decide which, if any, control strategy to implement, they need affordable, timely, and accurate data on dengue burden. Building on our previous work in Mexico, Indonesia, and Thailand, we developed a streamlined prospective method to estimate dengue burden at the municipal level quickly, accurately, and efficiently. Methods The method entails enrolling and repeatedly interviewing 100 patients with laboratory-confirmed dengue. They will be selected after screening and testing about 1,000 patients with clinical dengue. The method will capture both acute and chronic effects relating to disease, economic burden, and psychological impacts (presenteeism). The total time requirements are 1.5 years, comprised of 0.25 years for planning and approvals, 1 year for data collection (a full dengue cycle), and 0 .25 years for data cleaning and analysis. A collaboration with municipal and academic colleagues in the city of Semarang, Central Java, Indonesia shows how the method could be readily applied in Indonesia\u2019s eighth largest city (population 1.8 million). Conclusions Many surveillance studies gather only information on numbers of cases. This proposed method will provide a comprehensive picture of the dengue burden to the health system, payers, and households at the local level.\n                  <\/ns4:p>","DOI":"10.12688\/gatesopenres.15015.3","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T04:15:39Z","timestamp":1723090539000},"page":"3","update-policy":"https:\/\/doi.org\/10.12688\/gatesopenres.crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Estimating dengue disease and economic burden to inform municipal-level policymakers: Method for a pragmatic city-level observational cohort study"],"prefix":"10.12688","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2629-8330","authenticated-orcid":false,"given":"Nandyan N.","family":"Wilastonegoro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sri","family":"Andriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perigrinus H.","family":"Sebong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Agarwal-Harding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2187-0593","authenticated-orcid":false,"given":"Donald S.","family":"Shepard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2024,8,8]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002055","article-title":"Economic and disease  burden of dengue in Southeast Asia.","volume":"7","author":"D 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.21956\/gatesopenres.16348.r36009, Chanh Ho Quang, Oxford University Clinical Research, Ho Chi Minh City, 03 Apr 2024, version 1, 1 approved with reservations, 1 not approved","URL":"https:\/\/gatesopenresearch.org\/articles\/8-3\/v1#referee-response-36009","order":0,"name":"referee-response-36009","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Nandyan Wilastonegoro<\/b>; \n<i>Posted: 11 Jun 2024<\/i>;  The reviewer questioned our publication whether it could be reproducible or not.  \n<b>Authors' response:<\/b> We added further details about our selection procedures and concluded (around line 450): \u201cThese operational details should make our results reproducible.\u201d   The reviewer highlighted potential selection bias due to a relatively small sample size.  \n<b>Authors' response:<\/b> Our design seeks to minimize bias by selecting sites across multiple strata (facilities both with and without inpatient care).&nbsp; Given the purpose of the study, we acknowledge that it seeks to be pragmatic rather to give timely data at an affordable cost.   The reviewer mentioned the paper had no good rationale for the chosen sample size.  \n<b>Authors' response:<\/b> Economic data per episode tend to be more stable (less variable) than epidemiologic data, so smaller sample sizes can be sufficient for economic studies compared to epidemiologic studies.&nbsp; We added a paragraph beginning around line 233 about sample size.&nbsp; We show that the proposed sample size can generate a key economic result (overall cost per hospitalized episode) with an acceptable accuracy of 10%.&nbsp;   The reviewer required us to weigh the recruitment target anticipating seasonality.  \n<b>Authors' response:<\/b> We mentioned in our manuscript that this method includes one full dengue season and one partial dengue season in the first year (p5). We also stated how we randomly select cases to invite into the study through creating cycles and putting sites in a random order. This process ensures patients are enrolled over the course of the dengue season to make the cohort reasonably representative (p11).   The reviewer asked on how we would validate questionnaire\/tools  \n<b>Authors' response:<\/b> We mentioned that we would recommend applying the method using standardized questionnaire designed to minimize burden of both patients and researchers. We suggested selecting items from existing validated instruments (p14). For example:  Ascertaining quality of life using Euro-Qol structured questionnaire (p14) Ascertaining presenteeism using Work Performance Questionnaire, Work Limitations Questionnaire (WLQ)   The use of validated items saves time, increases confidence in our results, and ensures comparability with previous findings.   The reviewer asked was about our strategy to retain participants.  \n<b>Authors' response:<\/b> We mentioned in Figure 6 how we would recruit and retain participants. For example, we will offer refreshments to participants each time they come to the facility for study purposes.   The reviewer noted that we did not write specific results.  \n<b>Authors' response:<\/b> As our paper is entirely a methods paper, we do not have any results.&nbsp;","URL":"https:\/\/gatesopenresearch.org\/articles\/8-3\/v3#referee-comment-3697","order":1,"name":"referee-comment-3697","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/gatesopenres.16348.r36005, Fardhiasih Dwi Astuti, Ahmad Dahlan University, Yogyakarta, 11 May 2024, version 1, 1 approved with reservations, 1 not approved","URL":"https:\/\/gatesopenresearch.org\/articles\/8-3\/v1#referee-response-36005","order":2,"name":"referee-response-36005","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Nandyan Wilastonegoro<\/b>; \n<i>Posted: 11 Jun 2024<\/i>;  The reviewer mentioned that our title did not align with the abstract  \n<b>Authors' response:<\/b> We revised the background section of our abstract to better align with the title, highlight the method nature of our study.   The reviewer asked us to clarify and clearly state the purpose of our study  \n<b>Authors' response:&nbsp;<\/b>We added a subheading at line 185 as follows: \u201cOverall purpose of study,\u201d &nbsp;and clarified some of the text in that section.   The reviewer required us to detail how we would solve the listed research questions  \n<b>Authors' response:&nbsp;<\/b>To clarify, we added the word \u201cDomain\u201d around each of our areas.&nbsp; In the subsequent text, we, inserted sub-headings for each of our four domains to clarify the part of our methods that respond to each of our research questions   The reviewer asked us to clearly state the purpose of the study  \n<b>Authors' response:&nbsp;<\/b>See our response to the preceding comments.   The reviewer asked us to detail our method i.e., study design, sample collection, inclusion and exclusion criteria, and analysis  \n<b>Authors' response:&nbsp;<\/b>The introduction to Domain 1 indicates explicitly that our overall design is multi-stage observational study.&nbsp; The section \u201cInclusion and exclusion criteria\u201d around line 413 addresses these factors.&nbsp; We created a section called \u201cData analysis\u201d around line 537 (just before \u201cEthical considerations\u201d).   Another mention was about discussing our findings.  \n<b>Authors' response:&nbsp;<\/b>As this paper is purely a methods paper, we do not have any findings to discuss.&nbsp; We did, however, add a recommendation for users to disseminate their findings and explain that further in the section entitled \u201cDissemination.\u201d","URL":"https:\/\/gatesopenresearch.org\/articles\/8-3\/v3#referee-comment-3698","order":3,"name":"referee-comment-3698","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/gatesopenres.17671.r37701, Michael Tong, The Australian National University (Ringgold ID: 2219), Canberra, Australian Capital Territory, 29 Aug 2024, version 3, indexed","URL":"https:\/\/gatesopenresearch.org\/articles\/8-3\/v3#referee-response-37701","order":4,"name":"referee-response-37701","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/gatesopenres.17671.r37703, David Roiz, Univ. Montpellier, IRD, CNRS, Montpellier, 27 Aug 2024, version 3, indexed","URL":"https:\/\/gatesopenresearch.org\/articles\/8-3\/v3#referee-response-37703","order":5,"name":"referee-response-37703","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This work was supported in part by the Bill & Melinda Gates Foundation [OPP1187889]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":6,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}