{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:33:24Z","timestamp":1792103604572,"version":"4.4.0"},"reference-count":48,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T00:00:00Z","timestamp":1650585600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science Foundation Ireland research center grant","award":["12\/RC\/2273_P2. UN"],"award-info":[{"award-number":["12\/RC\/2273_P2. UN"]}]}],"content-domain":{"domain":["hrbopenresearch.org"],"crossmark-restriction":false},"short-container-title":["HRB Open Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background<\/ns4:bold>\n                    : The aim of this study was to measure the impact of post-acute sequelae of COVID-19 (PASC) on quality of life, mental health, ability to work and return to baseline health in an Irish cohort.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Methods<\/ns4:bold>\n                    :\u00a0We invited individuals with symptoms of COVID-19 lasting more than 14 days to participate in an anonymous online questionnaire. Basic demographic data and self-reported symptoms were recorded. Internationally validated instruments including the patient health questionnaire somatic, anxiety and depressive symptom scales (PHQ-SADS), the Patient Health Questionnaire-15 (PHQ-15) and Chadler fatigue scale (CFQ) were used.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Results<\/ns4:bold>\n                    : We analysed responses from 988 participants with self-reported confirmed (diagnostic\/antibody positive; 81%) or suspected (diagnostic\/antibody negative or untested; 9%) COVID-19.\u00a0The majority of respondents were female (88%), white (98%), with a median age of 43.0 (range 15 \u2013 88 years old) and a median BMI of 26.0 (range 16 \u2013 60). At the time of completing this survey, 89% of respondents reported that they have not returned to their pre-COVID-19 level of health.\u00a0The median number of symptoms reported was 8 (range 0 to 33 symptoms), with a median duration of 12 months (range 1 to 20 months) since time of acute infection. A high proportion of PASC patients reported that they have a moderate or severe limitation in their ability to carry out their usual activities, 38% report their ability to work is severely limited and 33% report a moderate, or higher, level of anxiety or depression.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusion<\/ns4:bold>\n                    : The results of this survey of an Irish cohort with PASC are in line with reports from other settings, and we confirm that patients with PASC reported prolonged, multi-system symptoms which can significantly impact quality of life, affect ability to work and cause significant disability. Dedicated multidisciplinary, cross specialty supports are required to improve outcomes of this patient group.\n                  <\/ns4:p>","DOI":"10.12688\/hrbopenres.13516.1","type":"journal-article","created":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T10:09:33Z","timestamp":1650622173000},"page":"31","update-policy":"https:\/\/doi.org\/10.12688\/hrbopenres.crossmark-policy","source":"Crossref","is-referenced-by-count":68,"title":["Impact of Long COVID on health and quality of life"],"prefix":"10.12688","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4705-3583","authenticated-orcid":false,"given":"Liam","family":"O\u2019 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.21956\/hrbopenres.14747.r32609, Joanna S. Makowska, Department of Rheumatology, Medical University of Lodz, \u0141\u00f3d\u017a, Poland, 16 Aug 2022, version 1, indexed","URL":"https:\/\/hrbopenresearch.org\/articles\/5-31\/v1#referee-response-32609","order":0,"name":"referee-response-32609","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/hrbopenres.14747.r32610, Jennifer L. P. Protudjer, The Children\u2019s Hospital Research Institute of Manitoba, Winnipeg, MB, Canada, 02 Sep 2022, version 1, indexed","URL":"https:\/\/hrbopenresearch.org\/articles\/5-31\/v1#referee-response-32610","order":1,"name":"referee-response-32610","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This study was supported by a Science Foundation Ireland research center grant 12\/RC\/2273_P2. UN is supported by the Swedish Research Council- Viral Diseases 2021 grant (2021-00993). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}