{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:34:45Z","timestamp":1793381685532,"version":"4.5.0"},"update-to":[{"DOI":"10.12688\/openreseurope.18026.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000}}],"reference-count":196,"publisher":"CERN","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Commission","award":["847468"],"award-info":[{"award-number":["847468"]}],"id":[{"id":"https:\/\/ror.org\/00k4n6c32","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Regional Government of Andalusia","award":["POSTDOC_21_028"],"award-info":[{"award-number":["POSTDOC_21_028"]}],"id":[{"id":"https:\/\/ror.org\/01jem9c82","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Open Res Europe"],"abstract":"<jats:p>Gestational Diabetes Mellitus (GDM) is the most frequent pregnancy-related medical issue and presents significant risks to both maternal and foetal health, requiring monitoring and management during pregnancy. The prevalence of GDM has surged globally in recent years, mirroring the rise in diabetes and obesity rates. Estimated to affect from 5% to 25% of pregnancies, GDM impacts approximately 21 million live births annually, according to the International Diabetes Federation (IDF). However, consensus on diagnostic approaches remains elusive, with varying recommendations from international organizations, which makes the comparison between research complicated. Compounding concerns are the short-term and long-term complications stemming from GDM for mothers and offspring. Maternal outcomes include heightened cardiovascular risks and a notable 70% risk of developing Type 2 Diabetes Mellitus (T2DM) within a decade postpartum. Despite this, research into the metabolic profiles associated with a previous GDM predisposing women to T2D remains limited. While genetic biomarkers have been identified, indicating the multifaceted nature of GDM involving hormonal changes, insulin resistance, and impaired insulin secretion, there remains a dearth of exploration into the enduring health implications for both mothers and their children. Furthermore, offspring born to mothers with GDM have been shown to face an increased risk of obesity and metabolic syndrome during childhood and adolescence, with studies indicating a heightened risk ranging from 20% to 50%. This comprehensive review aims to critically assess the current landscape of Gestational Diabetes Mellitus (GDM) research, focusing on its prevalence, diagnostic challenges, and health impacts on mothers and offspring. By examining state-of-the-art knowledge and identifying key knowledge gaps in the scientific literature, this review aims to highlight the multifaceted factors that have hindered a deeper understanding of GDM and its long-term consequences. Ultimately, this scholarly exploration seeks to promote further investigation into this critical area, improving health outcomes for mothers and their children.<\/jats:p>","DOI":"10.12688\/openreseurope.18026.2","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T06:30:08Z","timestamp":1731393008000},"update-policy":"https:\/\/doi.org\/10.68336\/openreseurope.updatepolicy","source":"Crossref","is-referenced-by-count":7,"title":["Gestational Diabetes Mellitus: Unveiling Maternal Health Dynamics from Pregnancy Through Postpartum Perspectives"],"prefix":"10.68336","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6662-2932","authenticated-orcid":true,"given":"Marina","family":"Mora-Ortiz","sequence":"first","affiliation":[{"name":"Lipids and Atherosclerosis Unit, Internal Medicine, Reina Sofia University Hospital, C\u00f3rdoba, Andaluc\u00eda, 14004, Spain"},{"name":"GC09-Nutrigenomics and Metabolic Syndrome, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), C\u00f3rdoba, Andaluc\u00eda, 14004, Spain"},{"name":"Department of Medical and Surgical Sciences, Universidad de Cordoba, C\u00f3rdoba, Andaluc\u00eda, 14004, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0413-8432","authenticated-orcid":true,"given":"Lorenzo","family":"Rivas-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Physiology, Institute of Nutrition and Food Technology \u201cJos\u00e9 Mataix Verd\u00fa\u201d, Biomedical Research Centre, Universidad de Granada, Armilla, Granada, Andalucia, 18016, Spain"},{"name":"Sport and Health Research Centre, Universidad de Granada, Armilla, Granada, Andalucia, 18016, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"13904","published-online":{"date-parts":[[2024,11,12]]},"reference":[{"key":"58268","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-S015"},{"key":"58269","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0098-8"},{"key":"58270","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2012.96"},{"key":"58271","doi-asserted-by":"publisher","DOI":"10.1080\/17446651.2018.1476135"},{"key":"58272","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-195706000-00008"},{"key":"58273","unstructured":"6. O\u2019sullivan JB, Mahan CM: Criteria for the Oral Glucose Tolerance Test in pregnancy. Diabetes. 1964; 13: 278\u201385. https:\/\/pubmed.ncbi.nlm.nih.gov\/14166677"},{"key":"58274","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.5.1674S"},{"key":"58275","doi-asserted-by":"publisher","DOI":"10.1016\/s0950-3552(05)80107-5"},{"key":"58276","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2015.4.10307"},{"key":"58277","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-3985-5"},{"key":"58278","doi-asserted-by":"publisher","DOI":"10.1900\/RDS.2008.5.194"},{"key":"58279","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-012-0360-x"},{"key":"58280","unstructured":"13. Cullinan J, Gillespie P, Owens L, et al.: Is there a socioeconomic gradient in the prevalence of Gestational Diabetes Mellitus? Ir Med J. 2012; 105(5 Suppl): 21\u20133. https:\/\/pubmed.ncbi.nlm.nih.gov\/22838104"},{"key":"58281","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-14-23"},{"key":"58282","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1848"},{"key":"58283","doi-asserted-by":"publisher","DOI":"10.2337\/dc24-S002"},{"key":"58284","unstructured":"17. Vandorsten JP, Dodson WC, Espeland MA, et al.: NIH consensus development conference: diagnosing Gestational Diabetes Mellitus. NIH Consens State Sci Statements. 2013; 29(1): 1\u201331. https:\/\/pubmed.ncbi.nlm.nih.gov\/23748438"},{"key":"58285","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002501"},{"key":"58286","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-011059"},{"key":"58287","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c1395"},{"key":"58288","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(82)90349-0"},{"key":"58289","doi-asserted-by":"publisher","DOI":"10.2337\/diab.28.12.1039"},{"key":"58290","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001383"},{"key":"58291","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-017-0922-z"},{"key":"58292","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.11628"},{"key":"58293","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0902430"},{"key":"58294","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042973"},{"key":"58295","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2026028"},{"key":"58296","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.05.009"},{"key":"58297","unstructured":"30. National Institute of Diabetes and Digestive and Kidney Diseases: Diabetes in America. 3rd Edition - NIDDK, [cited 2024 Jun 25]. Reference Source (https:\/\/www.niddk.nih.gov\/about-niddk\/strategic-plans-reports\/diabetes-in-america-3rd-edition)"},{"key":"58298","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-1646"},{"key":"58299","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-2398"},{"key":"58300","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-2159"},{"key":"58301","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-2397"},{"key":"58302","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20190338"},{"key":"58303","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1641"},{"key":"58304","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2011.03541.x"},{"key":"58305","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-12-81"},{"key":"58306","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-015-0699-x"},{"key":"58307","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2011.587921"},{"key":"58308","doi-asserted-by":"publisher","DOI":"10.1016\/j.midw.2011.08.014"},{"key":"58309","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-s206"},{"key":"58310","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.1997.10718704"},{"key":"58311","doi-asserted-by":"publisher","DOI":"10.1016\/s1262-3636(05)73649-1"},{"key":"58312","doi-asserted-by":"publisher","DOI":"10.1159\/000071233"},{"key":"58313","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550130052036"},{"key":"58314","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.51.7410"},{"key":"58315","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12082830"},{"key":"58316","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-016-1016-4"},{"key":"58317","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.05.032"},{"key":"58318","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178150"},{"key":"58319","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1336"},{"key":"58320","doi-asserted-by":"publisher","DOI":"10.2174\/1573399812666151022143502"},{"key":"58321","doi-asserted-by":"publisher","DOI":"10.2337\/diab.31.2.136"},{"key":"58322","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-11-56"},{"key":"58323","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.06.045"},{"key":"58324","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dml036"},{"key":"58325","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.57"},{"key":"58326","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a116408"},{"key":"58327","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2011.01322.x"},{"key":"58328","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/341638"},{"key":"58329","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-26412-6"},{"key":"58330","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1038"},{"key":"58331","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.293.3629"},{"key":"58332","doi-asserted-by":"publisher","DOI":"10.1136\/ebn.14.2.35"},{"key":"58333","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-0866"},{"key":"58334","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-0540"},{"key":"58335","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2002.10719227"},{"key":"58336","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-020-03299-8"},{"key":"58337","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.1795"},{"key":"58338","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0422-1"},{"key":"58339","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0000000000000587"},{"key":"58340","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201906-473OC"},{"key":"58341","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-023-05905-x"},{"key":"58342","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.001032"},{"key":"58343","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19113467"},{"key":"58344","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19113342"},{"key":"58345","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62154-6"},{"key":"58346","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9378(99)70662-9"},{"key":"58347","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.3.7339"},{"key":"58348","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9378(12)80011-1"},{"key":"58349","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2008.09.002"},{"key":"58350","doi-asserted-by":"publisher","DOI":"10.1016\/s0301-2115(03)00154-4"},{"key":"58351","doi-asserted-by":"publisher","DOI":"10.1159\/000371628"},{"key":"58352","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.19"},{"key":"58353","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.9.1807"},{"key":"58354","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0b013e32834c800d"},{"key":"58355","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-67-2-341"},{"key":"58356","doi-asserted-by":"publisher","DOI":"10.1016\/0098-2997(94)90004-3"},{"key":"58357","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198603000-00015"},{"key":"58358","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(91)90012-g"},{"key":"58359","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000443"},{"key":"58360","doi-asserted-by":"publisher","DOI":"10.1016\/s0143-4004(97)90004-7"},{"key":"58361","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.7.2207"},{"key":"58362","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.12.2951"},{"key":"58363","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2009.11.001"},{"key":"58364","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2013.00146"},{"key":"58365","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/217387"},{"key":"58366","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2015.01.033"},{"key":"58367","doi-asserted-by":"publisher","DOI":"10.15761\/DU.1000129"},{"key":"58368","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-014-0569-y"},{"key":"58369","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.47500"},{"key":"58370","doi-asserted-by":"publisher","DOI":"10.1016\/S1028-4559(08)60029-7"},{"key":"58371","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2000.tb11582.x"},{"key":"58372","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.831297"},{"key":"58373","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1790"},{"key":"58374","unstructured":"107. Spellacy WN, Miller S, Winegar A, et al.: Macrosomia--maternal characteristics and infant complications. Obstet Gynecol. 1985; 66(2): 158\u201361. https:\/\/pubmed.ncbi.nlm.nih.gov\/4022478"},{"key":"58375","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.302"},{"key":"58376","doi-asserted-by":"publisher","DOI":"10.1016\/s0950-3552(05)80101-4"},{"key":"58377","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.11.10.761"},{"key":"58378","doi-asserted-by":"publisher","DOI":"10.1053\/sp.2000.6364"},{"key":"58379","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2257"},{"key":"58380","doi-asserted-by":"publisher","DOI":"10.5863\/1551-6776-18.3.199"},{"key":"58381","doi-asserted-by":"publisher","DOI":"10.3345\/kjp.2014.57.4.157"},{"key":"58382","doi-asserted-by":"publisher","DOI":"10.4093\/jkd.2020.21.2.75"},{"key":"58383","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2017-000445"},{"key":"58384","doi-asserted-by":"publisher","DOI":"10.1186\/s13006-019-0238-5"},{"key":"58385","doi-asserted-by":"publisher","DOI":"10.1177\/0890334420950259"},{"key":"58386","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1409"},{"key":"58387","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2014.01.002"},{"key":"58388","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0393"},{"key":"58389","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-016-0338-0"},{"key":"58390","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-4840-2"},{"key":"58391","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0351"},{"key":"58392","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2009.11.017"},{"key":"58393","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g5450"},{"key":"58394","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2010.2233"},{"key":"58395","doi-asserted-by":"publisher","DOI":"10.1111\/jmwh.13641"},{"key":"58396","doi-asserted-by":"publisher","DOI":"10.1111\/jocn.15648"},{"key":"58397","doi-asserted-by":"publisher","DOI":"10.1111\/scs.12506"},{"key":"58398","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.2.385"},{"key":"58399","doi-asserted-by":"publisher","DOI":"10.1177\/1559827610393868"},{"key":"58400","doi-asserted-by":"publisher","DOI":"10.3390\/nu13113971"},{"key":"58401","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17093187"},{"key":"58402","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.10.001"},{"key":"58403","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1871"},{"key":"58404","doi-asserted-by":"publisher","DOI":"10.7196\/SAMJ.2019.v109i7.14064"},{"key":"58405","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-86818-7"},{"key":"58406","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1685446"},{"key":"58407","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0623-2"},{"key":"58408","doi-asserted-by":"publisher","DOI":"10.1039\/c5mb00064e"},{"key":"58409","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S298735"},{"key":"58410","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044398"},{"key":"58411","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/62915"},{"key":"58412","doi-asserted-by":"publisher","DOI":"10.1007\/BF03347566"},{"key":"58413","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2022-070312"},{"key":"58414","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.242407999"},{"key":"58415","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.3.819"},{"key":"58416","doi-asserted-by":"publisher","DOI":"10.51253\/pafmj.v73i1.8619"},{"key":"58417","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.35136"},{"key":"58418","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02429-2"},{"key":"58419","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3814"},{"key":"58420","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2024.106475"},{"key":"58421","doi-asserted-by":"publisher","DOI":"10.3390\/biom14010116"},{"key":"58422","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2023.2265381"},{"key":"58423","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2023.10.014"},{"key":"58424","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-022-01103-2"},{"key":"58425","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2023.123206"},{"key":"58426","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-021-01516-4"},{"key":"58427","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/6072286"},{"key":"58428","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.628289"},{"key":"58429","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1277153"},{"key":"58430","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00293.2024"},{"key":"58431","doi-asserted-by":"publisher","DOI":"10.1080\/10641955.2022.2033763"},{"key":"58432","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S433179"},{"key":"58433","doi-asserted-by":"publisher","DOI":"10.1111\/jog.15942"},{"key":"58434","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12144756"},{"key":"58435","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.280.5.E745"},{"key":"58436","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.83.7.4927"},{"key":"58437","doi-asserted-by":"publisher","DOI":"10.3390\/nu13041156"},{"key":"58438","doi-asserted-by":"publisher","DOI":"10.1016\/S1957-2557(09)70101-4"},{"key":"58439","doi-asserted-by":"publisher","DOI":"10.1002\/dmr.5610010407"},{"key":"58440","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-8847"},{"key":"58441","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-9-1"},{"key":"58442","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2021-0619"},{"key":"58443","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-19-0516"},{"key":"58444","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-0102"},{"key":"58445","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1722208"},{"key":"58446","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e31815a61d6"},{"key":"58447","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2465"},{"key":"58448","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-020-02892-1"},{"key":"58449","doi-asserted-by":"publisher","DOI":"10.2196\/28630"},{"key":"58450","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62071-1"},{"key":"58451","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b481"},{"key":"58452","doi-asserted-by":"publisher","DOI":"10.4158\/EP.9.6.504"},{"key":"58453","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.88"},{"key":"58454","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318195baef"},{"key":"58455","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000547"},{"key":"58456","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2011.02.013"},{"key":"58457","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2014.08.012"},{"key":"58458","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3915253"},{"key":"58459","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1584273"},{"key":"58460","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2020.108309"},{"key":"58461","doi-asserted-by":"publisher","DOI":"10.30574\/wjarr.2024.21.3.0822"},{"key":"58462","doi-asserted-by":"publisher","DOI":"10.4069\/kjwhn.2021.05.13"},{"key":"58463","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2020.04.002"}],"container-title":["Open Research Europe"],"original-title":[],"link":[{"URL":"https:\/\/open-research-europe.ec.europa.eu\/articles\/4-164\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ore.eu\/ore\/article\/download\/687\/version\/1208\/2413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ore.eu\/ore\/article\/download\/687\/version\/1208\/2414","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ore.eu\/ore\/article\/download\/687\/version\/1208\/2413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:11:58Z","timestamp":1793380318000},"score":1,"resource":{"primary":{"URL":"https:\/\/ore.eu\/ore\/article\/view\/687\/version\/1208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,12]]},"references-count":196,"URL":"https:\/\/doi.org\/10.12688\/openreseurope.18026.2","relation":{"is-version-of":[{"id-type":"doi","id":"10.12688\/openreseurope.18026.1","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.21956\/openreseurope.20373.r46147","asserted-by":"object"},{"id-type":"doi","id":"10.21956\/openreseurope.20373.r46145","asserted-by":"object"}]},"ISSN":["2732-5121"],"issn-type":[{"value":"2732-5121","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,12]]},"assertion":[{"value":"2024-11-12","name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"This project has received funding from the European Union\u2019s Horizon 2020 research and innovation programme under the Marie Sk\u0142odowska-Curie grant agreement No. 847468 (IMIBIC Fellowship Programme for Personalised and Precision Medicine [P2Med]). Furthermore, Lorenzo Rivas Garc\u00eda is supported by a postdoctoral fellowship financed by Junta de Andalucia (ref. POSTDOC_21_028).","name":"funding_statement","label":"Funding Statement","group":{"name":"funding_information","label":"Funding Information"}}],"article-number":"164"}}