{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:35:11Z","timestamp":1793381711472,"version":"4.5.0"},"update-to":[{"DOI":"10.12688\/openreseurope.19356.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000}}],"reference-count":38,"publisher":"CERN","license":[{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Commission","award":["CSA2020NoE3102"],"award-info":[{"award-number":["CSA2020NoE3102"]}],"id":[{"id":"https:\/\/ror.org\/00k4n6c32","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Open Res Europe"],"abstract":"<jats:p>Introduction\n                    Malaria in pregnancy remains a public health problem. The World Health Organization (WHO) recommends intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) to all pregnant women in moderate to high malaria transmission areas. Kenya's Ministry of Health recommends at least three doses of IPTp-SP (IPTp-SP3 +) to pregnant women in regions where malaria is endemic. Although SP remains cost-effective and effective for IPTp, there are two main challenges with the use of SP: i) widespread use of SP can lead to an increase in the prevalence of drug resistance molecular markers, including those encoding for \n                        Plasmodium falciparum dihydrofolate reductase (\n                        dhfr) and P\n                        f dihydropteroate synthase (\n                        dhps) and ii) SP, used either for curative or preventive treatment, is associated with microscopic and sub microscopic gametocytaemia, both of which contribute to sustained malaria transmission. Our study aims to investigate the dynamics of \n                        Plasmodium falciparum gametocyte carriage in pregnant women under intermittent preventive treatment with sulfadoxine-pyrimethamine in Kilifi.\n                \n                \n                    Methods\n                    This will be a cross-sectional study and will recruit (N=462) expectant women attending antenatal care (ANC) clinics in four health facilities within the Kilifi Health and Demographic Surveillance Sites: Njunju, Pingilikani, Ngerenya, and Kilifi County Teaching and Referral Hospital (KCTRH). To be recruited into our study, women will need to be in their first or second pregnancy when they are more likely to have malaria and should have had at least one dose of sulfadoxine-pyrimethamine.\n                \n                \n                    Expected application of results\n                    Our study will provide information on the current status of malaria during pregnancy in Kilifi and the prevalence of gametocytes among expectant mothers on IPT-SP. The results of this study may help inform new interventions to prevent malaria during pregnancy, including adding a third drug to SP with probable gametocytocidal effects.<\/jats:p>","DOI":"10.12688\/openreseurope.19356.2","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T11:55:06Z","timestamp":1744372506000},"update-policy":"https:\/\/doi.org\/10.68336\/openreseurope.updatepolicy","source":"Crossref","is-referenced-by-count":0,"title":["Investigating the dynamics of \n                    Plasmodium falciparum gametocyte carriage in expectant women under intermittent preventive treatment with sulfadoxine-pyrimethamine in Kilifi, study protocol"],"prefix":"10.68336","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3257-5920","authenticated-orcid":true,"given":"Patience Kerubo","family":"Kiyuka","sequence":"first","affiliation":[{"name":"Center for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kilifi County, 80108, Kenya"},{"name":"KEMRI Wellcome Trust Research Programme, Kilifi, 80108, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Muricho","sequence":"additional","affiliation":[{"name":"KEMRI Wellcome Trust Research Programme, Kilifi, 80108, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson","family":"Ouma","sequence":"additional","affiliation":[{"name":"KEMRI Wellcome Trust Research Programme, Kilifi, 80108, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Muiruri","sequence":"additional","affiliation":[{"name":"KEMRI Wellcome Trust Research Programme, Kilifi, 80108, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amek","family":"Nyaguara","sequence":"additional","affiliation":[{"name":"KEMRI Wellcome Trust Research Programme, Kilifi, 80108, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Rono","sequence":"additional","affiliation":[{"name":"Center for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kilifi County, 80108, Kenya"},{"name":"KEMRI Wellcome Trust Research Programme, Kilifi, 80108, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Oyier","sequence":"additional","affiliation":[{"name":"KEMRI Wellcome Trust Research Programme, Kilifi, 80108, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mainga","family":"Hamaluba","sequence":"additional","affiliation":[{"name":"KEMRI Wellcome Trust Research Programme, Kilifi, 80108, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"13904","published-online":{"date-parts":[[2025,4,11]]},"reference":[{"key":"72832","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-016-0883-2"},{"key":"72833","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2020-003217"},{"key":"72834","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2005.04.014"},{"key":"72835","doi-asserted-by":"publisher","DOI":"10.3390\/diseases12090203"},{"key":"72836","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00051-10"},{"key":"72837","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkv160"},{"key":"72838","doi-asserted-by":"publisher","DOI":"10.1172\/JCI98012"},{"key":"72839","unstructured":"Daniel WW: Biostatistics: a foundation for analysis in the health sciences. 7th edition. New York: John Wiley & Sons,1999. Reference Source (https:\/\/books.google.co.in\/books\/about\/Biostatistics.html?id=OrBpAAAAMAAJ&redir_esc=y)"},{"key":"72840","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ881"},{"key":"72841","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.1999.00361.x"},{"key":"72842","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(23)00211-2"},{"key":"72843","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-018-2498-8"},{"key":"72844","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-020-03286-6"},{"key":"72845","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac509"},{"key":"72846","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00335-09"},{"key":"72847","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.216231"},{"key":"72848","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-022-04213-7"},{"key":"72849","doi-asserted-by":"crossref","unstructured":"Kiyuka P: Replication Data for: Dynamics of Plasmodium falciparum gametocyte carriage in pregnant women under Intermittent Preventive Treatment with Sulfadoxine-Pyrimethamine and its resistance in Kilifi, study protocol. 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Reference Source (https:\/\/www.who.int\/teams\/global-malaria-programme\/reports\/world-malaria-report-2024)"},{"key":"72868","unstructured":"World malaria report 2023. (n.d.); Retrieved 14 October,2024. Reference Source (https:\/\/www.who.int\/teams\/global-malaria-programme\/reports\/world-malaria-report-2023)"},{"key":"72869","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed3010018"}],"container-title":["Open Research Europe"],"original-title":[],"link":[{"URL":"https:\/\/open-research-europe.ec.europa.eu\/articles\/5-60\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ore.eu\/ore\/article\/download\/858\/version\/1490\/2977","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ore.eu\/ore\/article\/download\/858\/version\/1490\/2978","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ore.eu\/ore\/article\/download\/858\/version\/1490\/2977","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:12:11Z","timestamp":1793380331000},"score":1,"resource":{"primary":{"URL":"https:\/\/ore.eu\/ore\/article\/view\/858\/version\/1490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,11]]},"references-count":38,"URL":"https:\/\/doi.org\/10.12688\/openreseurope.19356.2","relation":{"is-version-of":[{"id-type":"doi","id":"10.12688\/openreseurope.19356.1","asserted-by":"subject"}]},"ISSN":["2732-5121"],"issn-type":[{"value":"2732-5121","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,11]]},"assertion":[{"value":"2025-04-11","name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}},{"value":"This project has received funding from [European Union\u2019s Horizon Europe research and innovation programme] under grant agreement  NO [CSA 2020NOE-3102] East Africa Consortium for Clinical Research (EACCR)\n\n                    The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","name":"funding_statement","label":"Funding Statement","group":{"name":"funding_information","label":"Funding Information"}}],"article-number":"60"}}