{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:09:22Z","timestamp":1790363362738,"version":"4.1.0"},"update-to":[{"DOI":"10.12688\/wellcomeopenres.13083.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T00:00:00Z","timestamp":1533600000000}}],"reference-count":51,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T00:00:00Z","timestamp":1533600000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["102433"],"award-info":[{"award-number":["102433"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["wellcomeopenresearch.org"],"crossmark-restriction":false},"short-container-title":["Wellcome Open Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background<\/ns4:bold>\n                    : The relationship between adiposity at birth and in childhood, and telomere length is yet to be determined. We aimed to systematically review and meta-analyse the results of studies assessing associations between neonatal and later childhood adiposity, and telomere length.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Methods<\/ns4:bold>\n                    : We searched Medline, EMBASE and PubMed for studies reporting associations between adiposity measured in the neonatal period or later childhood\/adolescence, and leucocyte telomere length, measured at any age via quantitative polymerase chain reaction, or terminal restriction fragment analysis, either cross-sectionally, or longitudinally. Papers published before April 2017 were included.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Results<\/ns4:bold>\n                    : Out of 230 abstracts assessed, 23 papers (32 estimates) were retained, from which 19 estimates were meta-analysed (15 cross-sectional, four longitudinal). Of the 15 cross-sectional estimates, seven reported on neonates: four used binary exposures of small-for-gestational-age vs. appropriate-for-gestational age (or appropriate- and large-for-gestational age), and three studied birth weight continuously. Eight estimates reported on later childhood or adolescent measures; five estimates were from studies of binary exposures (overweight\/obese vs. non-obese children), and three studies used continuous measures of body mass index. All four longitudinal estimates were of neonatal adiposity, with two estimates for small-for-gestational-age vs. appropriate-for-gestational age neonates, and two estimates of birth weight studied continuously, in relation to adult telomere (49-61 years). There was no strong evidence of an association between neonatal or later childhood\/adolescent adiposity, and telomere length. However, between study heterogeneity was high, and there were few combinable studies.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusions<\/ns4:bold>\n                    : Our systematic review and meta-analysis found no strong evidence of an association between neonatal or later childhood or adolescent adiposity and telomere length.\n                  <\/ns4:p>","DOI":"10.12688\/wellcomeopenres.13083.2","type":"journal-article","created":{"date-parts":[[2018,8,7]],"date-time":"2018-08-07T09:25:08Z","timestamp":1533633908000},"page":"118","update-policy":"https:\/\/doi.org\/10.12688\/wellcomeopenres.crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Early life adiposity and telomere length across the life course: a systematic review and meta-analysis"],"prefix":"10.12688","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1860-6337","authenticated-orcid":false,"given":"Anna L.","family":"Guyatt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom R.","family":"Gaunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7741-9470","authenticated-orcid":false,"given":"Abigail","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma L.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2018,8,7]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"424-432","DOI":"10.1093\/ije\/dyw041","article-title":"The epigenetic clock and telomere length are independently associated with chronological age and 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.21956\/wellcomeopenres.16039.r33645, Mariana L. Tellechea, Institute of Medical Research (IDIM), National Scientific and Technical Research Council (CONICET), Buenos Aires University (UBA), Buenos Aires, Argentina, 23 Nov 2018, version 2, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/2-118\/v2#referee-response-33645","order":0,"name":"referee-response-33645","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/wellcomeopenres.16039.r33646, Eduardo Mundstock, Edgar Sarria, Rita Mattiello, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Pediatria e Sa\u00fade da Crian\u00e7a, Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil, 22 Aug 2018, version 2, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/2-118\/v2#referee-response-33646","order":1,"name":"referee-response-33646","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This work was supported by the Wellcome Trust [102433]; and the MRC Integrative Epidemiology Unit at the University of Bristol [MC_UU_12013\/8]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}