{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:25:10Z","timestamp":1787315110446,"version":"build-2736575974"},"update-to":[{"DOI":"10.12688\/wellcomeopenres.14565.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T00:00:00Z","timestamp":1532304000000}}],"reference-count":10,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T00:00:00Z","timestamp":1532304000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"crossref","award":["102215"],"award-info":[{"award-number":["102215"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007123","name":"Stanley Medical Research Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007123","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000883","name":"University of Bristol","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000883","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Medical Research Council"}],"content-domain":{"domain":["wellcomeopenresearch.org"],"crossmark-restriction":false},"short-container-title":["Wellcome Open Res"],"abstract":"<ns4:p>\n                    Antibodies against pathogens provide information on exposure to infectious agents and are meaningful measures of past and present infection. Antibodies were measured in the plasma of children that are the offspring in a population-based birth cohort, the Avon Longitudinal Study of Parents and Children (ALSPAC). Plasma was collected during clinics at age 5, 7, 11 and 15 years. The antigens examined include: fungal (\n                    <ns4:italic>Saccharomyces cerevisiae)<\/ns4:italic>\n                    ; protozoan (\n                    <ns4:italic>Toxoplasma gondii<\/ns4:italic>\n                    and surface antigen 1 of\u00a0\n                    <ns4:italic>T. gondii)<\/ns4:italic>\n                    ; herpes viruses (cytomegalovirus, Epstein-Barr virus, herpes simplex virus type 1); common colds (influenza virus subtypes H1N1 and H3N2); other antigens (measles); animal (feline herpes virus, Theiler\u2019s virus); bacteria (\n                    <ns4:italic>Helicobacter pylori<\/ns4:italic>\n                    ); dietary antigens (bovine casein alpha protein, bovine casein beta protein). Alongside the depth of data available within the ALSPAC cohort, this longitudinal resource will enable the investigation of the association between infections and a wide variety of outcomes.\n                  <\/ns4:p>","DOI":"10.12688\/wellcomeopenres.14565.2","type":"journal-article","created":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T07:45:08Z","timestamp":1532331908000},"page":"49","update-policy":"https:\/\/doi.org\/10.12688\/wellcomeopenres.crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Longitudinal serological measures of common infection in the Avon Longitudinal Study of Parents and Children cohort"],"prefix":"10.12688","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3506-160X","authenticated-orcid":false,"given":"Ruth E.","family":"Mitchell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5883-9605","authenticated-orcid":false,"given":"Hannah J.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Yolken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen","family":"Ford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9902-6902","authenticated-orcid":false,"given":"Lorraine","family":"Jones-Brando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3103-9330","authenticated-orcid":false,"given":"Susan M.","family":"Ring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alix","family":"Groom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"FitzGibbon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1407-8314","authenticated-orcid":false,"given":"George Davey","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7141-9189","authenticated-orcid":false,"given":"Nicholas John","family":"Timpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2018,7,23]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"179-185","DOI":"10.1016\/j.ijmm.2005.12.015","article-title":"Infectious diseases - 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Aiello, Rebecca Stebbins, Department\u00a0of\u00a0Epidemiology, Gillings School of Global Public Health, Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA, 27 Jun 2018, version 1, 1 approved","URL":"https:\/\/wellcomeopenresearch.org\/articles\/3-49\/v1#referee-response-33187","order":0,"name":"referee-response-33187","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Ruth Mitchell<\/b>; \n<i>Posted: 18 Jul 2018<\/i>; We thank the referee for their helpful comments.  We have edited the manuscript to provide clarity about why we recommend a subset of samples to be analysed separately. \u201cAs an initial pilot study, levels of antibodies to CMV, \n<i>T. gondii<\/i>, HSV-1, measles and whole casein antigen (a mixture of \u03b1-casein and \u03b2-casein) were measured in a random subset of samples (968 samples from 513 individuals). The sources of antigen used in this subset are distinct from the main sample and therefore it is recommended to analyse the results of this subset separately from the main sample as the antigens used are not directly comparable.\u201d","URL":"https:\/\/wellcomeopenresearch.org\/articles\/3-49\/v2#referee-comment-3650","order":1,"name":"referee-comment-3650","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.21956\/wellcomeopenres.16026.r33735, David Burgner, Royal Children's Hospital, Murdoch Children's Research Institute, Parkville, Vic, Australia, 04 Sep 2018, version 2, indexed","URL":"https:\/\/wellcomeopenresearch.org\/articles\/3-49\/v2#referee-response-33735","order":2,"name":"referee-response-33735","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This work is supported by the Stanley Medical Research Institute (SMRI). The UK Medical Research Council and Wellcome (Grant ref: 102215\/2\/13\/2) and the University of Bristol provide core support for ALSPAC. This publication is the work of the authors and Nicholas Timpson will serve as guarantor for the contents of this paper. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}